Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1H-1,2,3-triazoles: A Review of Their Anticancer Activity DOI Creative Commons
Delia Hernández‐Romero, Sharon Rosete‐Luna, Enrique Méndez-Bolaina

et al.

Reactions, Journal Year: 2024, Volume and Issue: 5(4), P. 947 - 983

Published: Nov. 24, 2024

Despite multiple advances in treatment and prevention, cancer remains one of the leading causes death worldwide. Chemotherapy most effective method for treatment. However, commercial chemotherapeutic drugs have limited efficacy, severe side effects, acquired resistance. Therefore, scientific community has devoted a great effort to designing new, more effective, cheaper drugs. In this sense, copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) provide 1,4-disubstituted 1H-1,2,3-triazoles high yields without forming by-products. This reaction allows easy, efficient, functional, ordered, rapid, selective, specific joining small molecules, giving rise complex molecules. The CuACC simplifies synthesis processes, accelerating discovery new agents by allowing platinum drugs, slightly altering their structure, or creating molecules with improved properties. work shows importance CuAAC search metallodrugs possible anticancer activity.

Language: Английский

Recent advances in fluorescent probes for ATP imaging DOI
Chen Zhang, Guanzhao Wu

Talanta, Journal Year: 2024, Volume and Issue: 279, P. 126622 - 126622

Published: July 28, 2024

Language: Английский

Citations

6
Nasopharyngeal cancer screening and immunotherapy efficacy evaluation based on plasma separation combined with label-free SERS technology DOI

Ruiying Lin,

Zhengjin Jiang, Jinyong Lin

et al.

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 344070 - 344070

Published: April 1, 2025

Language: Английский

Citations

0
Liquid Biopsy-Derived Tumor Biomarkers for Clinical Applications in Glioblastoma DOI Creative Commons

Bruna Pereira de Lima,

Letícia S. Ferraz, Sylvie Devalle

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 658 - 658

Published: May 2, 2025

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, characterized by rapid growth and resistance to chemotherapy. Conventional treatments remain largely ineffective, with patient survival averaging around 18 months after diagnosis. Current diagnostic methods rely on invasive tissue biopsies imaging tests. While traditional involve extracting samples, their routine use often limited surgical risks challenge of accessing sensitive regions. Liquid biopsy has emerged as a promising noninvasive alternative, analyzing circulating components—such DNA, RNA, extracellular vesicles, microRNAs—found body fluids. This approach enables initial diagnosis continuous disease monitoring, offering significant advantage over biopsies, which are impractical for frequent repetition during treatment follow-up. review highlights recent advances liquid biopsy-derived biomarkers clinical management GBM. The discussion includes advantages, limitations, potential these tools early monitoring. A narrative literature published last decade (2014–2024) was conducted using major health-focused scientific databases. analysis focuses evaluating relevance applicability GBM, insights into its minimally effective tool improving glioblastoma management.

Language: Английский

Citations

0
Systemic toxicity of CAR-T therapy and potential monitoring indicators for toxicity prevention DOI Creative Commons
Jingxian Li,

Huiguang Chen,

Chaoping Xu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 26, 2024

Malignant tumors of the hematologic system have a high degree malignancy and mortality rates. Chimeric antigen receptor T cell (CAR-T) therapy has become an important option for patients with relapsed/refractory tumors, showing astonishing therapeutic effects thus, it brought new hope to treatment malignant system. Despite significant CAR-T, its toxic reactions, such as Cytokine Release Syndrome (CRS) Immune Effector Cell-Associated Neurotoxicity (ICANS), cannot be ignored since they can cause damage multiple systems, including cardiovascular We summarize biomarkers related prediction, diagnosis, efficacy, prognosis, further exploring potential monitoring indicators toxicity prevention. This review aims CAR-T on cardiovascular, hematologic, nervous well biomarkers, explore preventing toxicity, thereby providing references clinical regulation assessment effects.

Language: Английский

Citations

2
Winners of the 2023 honor awards for excellence at the annual meeting of the Chinese Medical Association-Taipei: Part III DOI Creative Commons
Peng‐Hui Wang,

Szu‐Ting Yang

Journal of the Chinese Medical Association, Journal Year: 2024, Volume and Issue: 87(9), P. 815 - 816

Published: June 25, 2024

Language: Английский

Citations

1
Concordance of HER2 status between primary tumor and circulating tumor cells in breast cancer DOI Creative Commons

Peipei Xie,

Xiaoli Zhang, Tianyi Liu

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 18, 2024

During tumor progression, HER2 expression undergoes dynamic changes. Circulating cells (CTCs) can be used to monitor in real-time and hold potential for clinical application. This study aimed evaluate the consistency of between primary tumors CTCs patients with breast cancer (BC). We a previously established telomerase reverse transcriptase-based CTC detection method (TBCD) combined anti-HER2 antibody detect HER2-positive (HER2 + CTC) 4 ml peripheral blood from prior radiotherapy. The results indicated that status was inconsistent histological results. Discordance observed 32.6% (kappa value = 0.325, p 0.03). And among histologically HER2-negative cancer, rate 32.1% (9/28). found findings. Further research should explore significance detecting CTCs, it is desired testing could cancer.

Language: Английский

Citations

1
Evaluation and integration of cell-free DNA signatures for detection of lung cancer DOI Creative Commons
Ruyue Xue, Xiaomin Li,

Lu Yang

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 604, P. 217216 - 217216

Published: Sept. 3, 2024

Language: Английский

Citations

0
Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1H-1,2,3-triazoles: A Review of Their Anticancer Activity DOI Creative Commons
Delia Hernández‐Romero, Sharon Rosete‐Luna, Enrique Méndez-Bolaina

et al.

Reactions, Journal Year: 2024, Volume and Issue: 5(4), P. 947 - 983

Published: Nov. 24, 2024

Despite multiple advances in treatment and prevention, cancer remains one of the leading causes death worldwide. Chemotherapy most effective method for treatment. However, commercial chemotherapeutic drugs have limited efficacy, severe side effects, acquired resistance. Therefore, scientific community has devoted a great effort to designing new, more effective, cheaper drugs. In this sense, copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) provide 1,4-disubstituted 1H-1,2,3-triazoles high yields without forming by-products. This reaction allows easy, efficient, functional, ordered, rapid, selective, specific joining small molecules, giving rise complex molecules. The CuACC simplifies synthesis processes, accelerating discovery new agents by allowing platinum drugs, slightly altering their structure, or creating molecules with improved properties. work shows importance CuAAC search metallodrugs possible anticancer activity.

Language: Английский

Citations

0