Advancing Chrononutrition for Cardiometabolic Health: A 2023 National Heart, Lung, and Blood Institute Workshop Report DOI Creative Commons
Hassan S. Dashti, Erica C. Jansen, Faris M. Zuraikat

et al.

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

The circadian system maintains optimal biological functions at the appropriate time of day, and disruption this organization can contribute to pathogenesis cardiometabolic disorders. timing eating is a prominent external cue that influences system. “Chrononutrition” an emerging dimension nutrition active area research examines how timing‐related aspects impact rhythms, processes, disease pathogenesis. There evidence support chrononutrition as form chronotherapy, such optimizing may serve actionable strategy improve health. This report summarizes key information from National Heart, Lung, Blood Institute's virtual workshop entitled “Chrononutrition: Elucidating Role Circadian Biology Meal Timing in Cardiometabolic Health,” which convened on May 2 3, 2023, review current literature identify critical knowledge gaps opportunities. speakers presented highlighting health earlier shorter windows more consistent day‐to‐day patterns. multidimensionality was common theme, it encompasses multiple facets along with other behaviors including sleep physical activity. Advancing field will require: (1) standardization terminology metrics; (2) scalable precise tools for real‐world settings; (3) consideration individual differences act effect modifiers; (4) deeper understanding social, behavioral, cultural influences. Ultimately, there great potential circadian‐based dietary interventions

Language: Английский

Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity DOI
Humaira Jamshed, Felicia L. Steger,

David R. Bryan

et al.

JAMA Internal Medicine, Journal Year: 2022, Volume and Issue: 182(9), P. 953 - 953

Published: Aug. 8, 2022

Importance

It is unclear how effective intermittent fasting for losing weight and body fat, the effects may depend on timing of eating window. This randomized trial compared time-restricted (TRE) with over a period 12 or more hours while matching weight-loss counseling across groups.

Objective

To determine whether practicing TRE by early in day (eTRE) loss, fat cardiometabolic health than hours.

Design, Setting, Participants

The study was 14-week, parallel-arm, clinical conducted between August 2018 April 2020. Participants were adults aged 25 to 75 years obesity who received treatment through Weight Loss Medicine Clinic at University Alabama Birmingham Hospital.

Interventions

All participants (energy restriction [ER]) eTRE plus ER (8-hour window from 7:00 15:00) control (CON) (≥12-hour window).

Main Outcomes Measures

co–primary outcomes loss loss. Secondary included blood pressure, heart rate, glucose levels, insulin plasma lipid levels.

Results

Ninety enrolled (mean [SD] mass index, 39.6 [6.7]; age, 43 [11] years; 72 [80%] female). eTRE+ER group adhered 6.0 (0.8) days per week. intervention (−2.3 kg; 95% CI, −3.7 −0.9 kg;P = .002) but did not affect (−1.4 −2.9 0.2 .09) ratio (−4.2%; −14.9 6.5%;P .43). equivalent reducing calorie intake an additional 214 kcal/d. also improved diastolic pressure (−4 mm Hg; −8 0 Hg;P .04) mood disturbances, including fatigue-inertia, vigor-activity, depression-dejection. other risk factors, food intake, physical activity, sleep similar In secondary analysis 59 completers, trunk CON+ER.

Conclusions Relevance

this trial, improving 14 weeks.

Trial Registration

ClinicalTrials.gov Identifier:NCT03459703

Language: Английский

Citations

146
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity DOI Creative Commons

Nina Vujović,

Matthew J. Piron,

Jingyi Qian

et al.

Cell Metabolism, Journal Year: 2022, Volume and Issue: 34(10), P. 1486 - 1498.e7

Published: Oct. 1, 2022

Language: Английский

Citations

91
A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults DOI
Iain Templeman, Harry Smith, Enhad A. Chowdhury

et al.

Science Translational Medicine, Journal Year: 2021, Volume and Issue: 13(598)

Published: June 16, 2021

Daily energy restriction more effectively reduces body fat content than alternate-day fasting, with no evidence of fasting-specific health benefits.

Language: Английский

Citations

85
Early time‐restricted eating compared with daily caloric restriction: A randomized trial in adults with obesity DOI
Elizabeth A. Thomas, Adnin Zaman,

Kelsey J. Sloggett

et al.

Obesity, Journal Year: 2022, Volume and Issue: 30(5), P. 1027 - 1038

Published: April 26, 2022

This trial aimed to evaluate the acceptability and efficacy of early time-restricted eating plus daily caloric restriction (E-TRE+DCR) compared with DCR alone within a behavioral weight-loss intervention.Participants (n = 81, 69 women, mean [SD] age: 38.0 [7.8] years, BMI: 34.1 [5.7] kg/m2 ) were randomized E-TRE (10-hour window starting 3 hours waking) or (~35% DCR) for 39 weeks. The primary outcome was body weight (measured digital scale) at week 12. Secondary outcomes measured 12 included hemoglobin A1c, lipids, energy intake (photographic food records), physical activity (accelerometry), dietary adherence (questionnaires), composition (dual-energy x-ray absorptiometry). Weight also assessed 39.Mean loss not different between groups (E-TRE+DCR: -6.2 [4.1] kg vs. DCR: -5.1 [3.2] kg) (E-TRE: -4.9 [5.3] -4.3 kg). There no between-group differences in changes composition, adherence, intake, activity, lipids 12.E-TRE+DCR found be an acceptable strategy, resulting similar levels alone.

Language: Английский

Citations

65
The circadian system, sleep, and the health/disease balance: a conceptual review DOI Creative Commons
Till Roenneberg, F. Foster, Elizabeth B. Klerman

et al.

Journal of Sleep Research, Journal Year: 2022, Volume and Issue: 31(4)

Published: June 7, 2022

Summary The field of “circadian medicine” is a recent addition to chronobiology and sleep research efforts. It represents logical step arising from the increasing insights into circadian system its interactions with life in urbanised societies; applying these health/disease balance at home medical practice (outpatient) clinic (inpatient). Despite fast expansion proliferating efforts, medicine lacks formal framework categorise many observations describing among system, sleep, balance. A good allows us then assign them one or more components hypothesised interactions. Such assignments can lead experiments that document causal (rather than correlational) relationships move discovering mechanisms. This review details such proposed for will hopefully trigger discussion our colleagues, so be improved expanded. As basis medicine, we define health” how it links general health. We put context literature examples six domains balance: fertility, cancer, immune mental health, cardiovascular, metabolism.

Language: Английский

Citations

54
Complex physiology and clinical implications of time-restricted eating DOI
Max C. Petersen,

Molly R. Gallop,

Stephany Flores Ramos

et al.

Physiological Reviews, Journal Year: 2022, Volume and Issue: 102(4), P. 1991 - 2034

Published: July 14, 2022

Time-restricted eating (TRE) is a dietary intervention that limits food consumption to specific time window each day. The effect of TRE on body weight and physiological functions has been extensively studied in rodent models, which have shown considerable therapeutic effects important interactions among eating, circadian biology, metabolic homeostasis. In contrast, it difficult make firm conclusions regarding the people because heterogeneity results, regimens, study populations. this review, we 1) provide background history meal normal physiology fasting; 2) discuss interaction between molecular metabolism TRE; 3) integrate results preclinical clinical studies evaluated functions; 4) summarize other time-related interventions people; identify current gaps knowledge framework for future research directions.

Language: Английский

Citations

42
Timing Matters: The Interplay between Early Mealtime, Circadian Rhythms, Gene Expression, Circadian Hormones, and Metabolism—A Narrative Review DOI Creative Commons
Ahmed S. BaHammam, Rouf Pirzada

Clocks & Sleep, Journal Year: 2023, Volume and Issue: 5(3), P. 507 - 535

Published: Sept. 6, 2023

Achieving synchronization between the central and peripheral body clocks is essential for ensuring optimal metabolic function. Meal timing an emerging field of research that investigates influence eating patterns on our circadian rhythm, metabolism, overall health. This narrative review examines relationship meal timing, clock genes, hormones, It analyzes existing literature experimental data to explore connection mealtime, rhythms, processes. The available evidence highlights importance aligning mealtime with body’s natural rhythms promote health prevent disorders. Specifically, studies show consuming meals later in day associated elevated prevalence disorders, while early time-restricted eating, such as having breakfast earlier dinner, improves levels glucose blood substrate oxidation. Circadian including cortisol melatonin, interact mealtimes play vital roles regulating Cortisol, aligned dawn diurnal mammals, activates energy reserves, stimulates appetite, influences gene expression, synchronizes clocks. Consuming during periods melatonin levels, specifically night, has been correlated potential implications tolerance. Understanding mechanisms synchronization, genetics, interactions chronotype, sleep duration, hormonal changes, provides valuable insights optimizing dietary strategies timing. knowledge contributes improved well-being by rhythm.

Language: Английский

Citations

39
Circadian regulation of liver function: from molecular mechanisms to disease pathophysiology DOI
Nityanand Bolshette, Hussam Ibrahim, Hans Reinke

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 20(11), P. 695 - 707

Published: June 8, 2023

Language: Английский

Citations

32
Circadian desynchrony and glucose metabolism DOI Creative Commons
Esther M. Speksnijder, Peter H. Bisschop, Sarah E. Siegelaar

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(4)

Published: May 1, 2024

Abstract The circadian timing system controls glucose metabolism in a time‐of‐day dependent manner. In mammals, the consists of main central clock bilateral suprachiasmatic nucleus (SCN) anterior hypothalamus and subordinate clocks peripheral tissues. oscillations produced by these different with period approximately 24‐h are generated transcriptional‐translational feedback loops set core genes. Glucose homeostasis is one daily rhythms controlled this system. pacemaker SCN through its neural projections to hypothalamic hubs that control feeding behavior energy metabolism. Using hormones such as adrenal glucocorticoids melatonin autonomic nervous system, modulates critical processes production insulin sensitivity. Peripheral tissues, liver, muscle, adipose tissue serve enhance sustain signals. optimal situation all synchronized aligned environmental light/dark cycle. A negative impact on becomes apparent when internal disturbed, also known desynchrony or misalignment. Circadian may occur at several levels, mistiming light exposure sleep will especially affect clock, whereas food intake physical activity involve clocks. review, we summarize literature investigating how it result development resistance. addition, discuss potential strategies aimed reinstating synchrony improve sensitivity contribute prevention type 2 diabetes.

Language: Английский

Citations

15
Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity? DOI Creative Commons

Maria Eugenia Parrotta,

Luca Colangeli,

Valeria SCIPIONE

et al.

Current Obesity Reports, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 3, 2025

Language: Английский

Citations

1