How Protein Depletion Balances Thrombosis and Bleeding Risk in the Context of Platelet’s Activatory and Negative Signaling DOI Open Access
Héctor Montecino-Garrido, Andrés Trostchansky, Yolanda Espinosa‐Parrilla

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10000 - 10000

Published: Sept. 17, 2024

Platelets are small cell fragments that play a crucial role in hemostasis, requiring fast response times and fine signaling pathway regulation. For this regulation, platelets require balance between two types: the activatory negative pathways. Activatory mediators positive responses enhance stimuli initiated by receptor platelet membrane. Negative regulates controls downstream of same receptors to roll back or even avoid spontaneous thrombotic events. Several blood-related pathologies can be observed when these processes unregulated, such as massive bleeding inhibition events for inhibition. The study each protein metabolite isolation does not help understand how it contrasted; however, understanding active could develop effective therapies prevent disorders.

Language: Английский

Investigating the Interplay Between the Nrf2/Keap1/HO-1/SIRT-1 Pathway and the p75NTR/PI3K/Akt/MAPK Cascade in Neurological Disorders: Mechanistic Insights and Therapeutic Innovations DOI

R Mukherjee,

R.S. Rana,

Sidharth Mehan

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

0
Molecular mechanisms of GDNF/GFRA1/RET and PI3K/AKT/ERK signaling interplay in neuroprotection: Therapeutic strategies for treating neurological disorders DOI

Manzar Khan,

Divya Choudhary,

Sidharth Mehan

et al.

Neuropeptides, Journal Year: 2025, Volume and Issue: 111, P. 102516 - 102516

Published: March 12, 2025

Language: Английский

Citations

0
A molecular systems architecture of neuromuscular junction in amyotrophic lateral sclerosis DOI Creative Commons

V. A. Shiva Ayyadurai,

Prabhakar Deonikar,

Roger D. Kamm

et al.

npj Systems Biology and Applications, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 17, 2025

A molecular systems architecture is presented for the neuromuscular junction (NMJ) in order to provide a framework organizing complexity of biomolecular interactions amyotrophic lateral sclerosis (ALS) using systematic literature review process. ALS fatal motor neuron disease characterized by progressive degeneration upper and lower neurons that supply voluntary muscles. The contains cells such as neurons, skeletal muscle cells, astrocytes, microglia, Schwann endothelial which are implicated pathogenesis ALS. This provides multi-layered understanding intra- inter-cellular microenvironment, may be utilized target identification, discovery single combination therapeutics, clinical strategies treat

Language: Английский

Citations

0
Oxidative Stress and Redox Imbalance: Common Mechanisms in Cancer Stem Cells and Neurodegenerative Diseases DOI Creative Commons

Nikhil Raj Selvaraj,

Durga Nandan,

B J Bipin Nair

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 511 - 511

Published: March 29, 2025

Oxidative stress (OS) is an established hallmark of cancer and neurodegenerative disorders (NDDs), which contributes to genomic instability neuronal loss. This review explores the contrasting role OS in stem cells (CSCs) NDDs. Elevated levels reactive oxygen species (ROS) contribute promote tumor initiation progression CSCs, while NDDs such as Alzheimer’s Parkinson’s disease, accelerates death impairs cellular repair mechanisms. Both scenarios involve disruption delicate balance between pro-oxidant antioxidant systems, leads chronic oxidative stress. Notably, CSCs neurons display alterations redox-sensitive signaling pathways, including Nrf2 NF-κB, influence cell survival, proliferation, differentiation. Mitochondrial dynamics further illustrate these differences: enhanced function supports adaptability whereas impairments heighten vulnerability. Understanding common mechanisms OS-induced redox imbalance may provide insights for developing interventions, addressing aging hallmarks, potentially mitigating or preventing both

Language: Английский

Citations

0
Role of Fibroblast Growth Factors in Neurological Disorders: Insight into Therapeutic Approaches and Molecular Mechanisms DOI
Shubham Upadhayay,

Divya Soni,

Maanvi Dhureja

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Language: Английский

Citations

0
Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy DOI Creative Commons
Yashumati Ratan, Aishwarya Rajput, Ashutosh Pareek

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1390 - 1390

Published: June 23, 2024

Diabetic neuropathy (DN) is a neurodegenerative disorder that primarily characterized by distal sensory loss, reduced mobility, and foot ulcers may potentially lead to amputation. The multifaceted etiology of DN linked range inflammatory, vascular, metabolic, other factors. Chronic inflammation, endothelial dysfunction, oxidative stress are the three basic biological changes contribute development DN. Although our understanding intricacies has advanced significantly over past decade, distinctive mechanisms underlying condition still poorly understood, which be reason behind lack an effective treatment cure for present study delivers comprehensive highlights potential role several pathways molecular etiopathogenesis Moreover, Schwann cells satellite glial cells, as integral factors in pathogenesis DN, have been enlightened. This work will motivate allied research disciplines gain better analysis current state biomolecular essential effectively address every facet from prevention treatment.

Language: Английский

Citations

3
Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration DOI Creative Commons

Elaine Kellett,

Adekunle T. Bademosi, Adam K. Walker

et al.

Molecular Neurodegeneration, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 8, 2025

Language: Английский

Citations

0
Protein kinase inhibitors as therapeutics in neurodegenerative and psychiatric disorders DOI
Giuseppe Tridente, Ankit Jana,

Arnab Nath

et al.

Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 403 - 573

Published: Jan. 1, 2023

Language: Английский

Citations

7
Phytotherapy in Alzheimer’s Disease—A Narrative Review DOI Creative Commons
Julia Piekarz, Natalia Picheta,

Oliwia Burdan

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1812 - 1812

Published: Aug. 9, 2024

Alzheimer's disease (AD) affects 50-70% of patients with dementia, making it the leading cause dementia. The condition is classified as a neurodegenerative, progressive and incurable disease. affecting more people around world. AD has multifactorial nature, spreading from beta-amyloid deposition to inflammation in patients' brains. Patients experience cognitive impairment functional decline. Although that occurs mainly elderly, increasingly being diagnosed young between ages 30 40. It not only patient themself but also reduces quality life their closest caregivers. According WHO, treatment consumes USD 1.3 trillion globally, symptomatic, there are no drugs prevent onset or treat its onset. Due numerous side effects therapy lack proactive act on pathomechanism AD, alternative therapies sought. One possible option many studies confirming effect phytotherapy. Many herbs have pharmacological properties, such antioxidant, anti-inflammatory, neuroprotective effects, them future disorders treatment. This review focuses some most promising potentially potent properties therapy. These include

Language: Английский

Citations

2
Ferroptosis-related gene MAPK3 is associated with the neurological outcome after cardiac arrest DOI Creative Commons

Hong xiang Hou,

Li Pang, Liang Zhao

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(6), P. e0301647 - e0301647

Published: June 17, 2024

Background Neuronal ferroptosis is closely related to the disease of nervous system, and objective present study was recognize verify potential ferroptosis-related genes forecast neurological outcome after cardiac arrest. Methods Cardiac Arrest-related microarray datasets GSE29540 GSE92696 were downloaded from GEO batch normalization expression data performed using “sva” R package. GSE2 9540 analyzed identify DEGs. Venn diagram applied DEGs Subsequently, The Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis performed, PPI network screen hub genes. Receiver operating characteristic (ROC) curves adopted determine predictive value biomarkers, dataset further evaluate diagnostic efficacy biomarkers. We explore transcription factors miRNAs associated with “CIBERSORT” package utilized analyse proportion infiltrating immune cells. Finally, validated by a series experiments at cellular level. Results 112 overlapping obtained via intersecting these GO KEGG demonstrate that are mainly involved in response oxidative stress, ferroptosis, apoptosis, IL-17 signalling pathway, autophagy, toll-like receptor pathway. top 10 selected, including HIF1A, MAPK3, PPARA, IL1B, PTGS2, RELA, TLR4, KEAP1, SREBF1, SIRT6. Only MAPK3 upregulated both GAE92696. AUC values 0.654 0.850 respectively. result indicates hsa-miR-214-3p hsa-miR-483-5p can regulate MAPK3. positively correlated naive B cells, macrophages M0, activated dendritic cells negatively CD4 memory T CD8 Compared OGD4/R24 group, OGD4/R12 group had higher mRNA protein levels more severe ferroptosis. Conclusion In summary, gene could be used as biomarker predict Potential biological pathways provide novel insights into pathogenesis

Language: Английский

Citations

1