Synthesis of Substituted α-Carboline Derivatives by Base-Mediated Annulation of Azaindoles with Alkylidene Malononitriles DOI Creative Commons
Venkata Rao Kaki,

Aakansha Negi,

Harshini Gaddam

et al.

Synlett, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract A new synthetic method has been established to synthesize α-carbolines through the reaction of electrophilic azaindoles with ambiphilic alkylidene malononitriles. The versatility this approach was explored by using various malononitriles, and also conducting nitrogen migration on azaindole. This enables simultaneous introduction diverse functional groups, such as amine, nitrile, aryl, onto benzene ring a carboline scaffold. As scaffold putatively shows antiproliferative other biological activities, is valuable in development chemical entities for drug discovery.

Language: Английский

Synthesis of Substituted α-Carboline Derivatives by Base-Mediated Annulation of Azaindoles with Alkylidene Malononitriles DOI Creative Commons
Venkata Rao Kaki,

Aakansha Negi,

Harshini Gaddam

et al.

Synlett, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract A new synthetic method has been established to synthesize α-carbolines through the reaction of electrophilic azaindoles with ambiphilic alkylidene malononitriles. The versatility this approach was explored by using various malononitriles, and also conducting nitrogen migration on azaindole. This enables simultaneous introduction diverse functional groups, such as amine, nitrile, aryl, onto benzene ring a carboline scaffold. As scaffold putatively shows antiproliferative other biological activities, is valuable in development chemical entities for drug discovery.

Language: Английский

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