Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 407 - 417
Published: Feb. 1, 2023
Psoriasis,
a
chronic
immune-mediated
inflammatory
skin
disease,
influences
approximately
2-3%
of
the
world's
population.
At
present,
etiology
psoriasis
remains
unclear
and
there
is
still
no
causal
treatment
available.
Recent
studies
indicate
that
oxidative
stress
(OS)
T
cells
dysregulation
may
participate
in
pathogenesis
psoriasis,
among
which
M1-dominant
macrophage
polarization
crucial
contributor.
Macrophages
mainly
polarize
into
two
different
subsets,
ie,
classically
activated
(M1)
alternatively
(M2).
M1
tends
to
exacerbate
via
producing
substantial
reactive
oxygen
species
(ROS)
mediators,
encourage
OS
invasion
dysregulation.
Thus,
targeting
can
be
possible
therapeutic
alternative
for
psoriasis.
Loganin,
belonging
iridoid
glycosides,
pharmaceutically
active
ingredient
originated
from
Cornus
officinalis,
exerting
multiple
biological
activities,
eg,
immunomodulation,
antioxidation,
anti-inflammation,
etc.
More
importantly,
it
could
effectively
suppress
polarization,
thereby
arresting
aggression
cells'
Numerous
have
confirmed
loganin
quite
reliable
diseases
suppressing
polarization.
Nevertheless,
reports
about
treating
seldom
appeared
so
far.
Accordingly,
we
hold
hypothesis
would
availably
manage
through
preventing
Data
previous
guarantee
potential
control
European Polymer Journal,
Journal Year:
2023,
Volume and Issue:
187, P. 111868 - 111868
Published: Jan. 31, 2023
The
increasing
emergence
of
skin
diseases
and
the
difficulty
in
treating
damaged
using
conventional
therapies
have
been
calling
for
development
novel
drug
delivery
systems
towards
an
effective
topical
administration.
Drug
are
able
to
produce
these
results
by
means
improved
features,
including
controlled
release,
increased
permeation
retention,
decreased
systemic
adverse
effects.
Natural
polymers
proved
be
good
excipients
incorporation
hybrid
(nanocarriers
dispersed
a
semisolid
base)
management
affections.
In
addition
being
biocompatible,
biodegradable,
economic,
easily
available
based
on
renewable
resources,
natural
also
intrinsic
bioactive
properties
that
greatly
enhance
their
applicability
systems.
Examples
such
chitosan,
alginate,
agarose,
starch,
hyaluronic
acid,
silk
fibroin,
collagen,
gelatin,
many
others.
These
play
crucial
role
preparation
polymeric
nanoparticles,
increase
penetration,
but
bases
cutaneous
application,
which
improves
viscosity
formulations
and,
consequently,
provides
suitable
application
diseases.
This
review
aims
present
discuss
some
latest
system
technologies
analyze
respective
vitro,
ex
vivo
experiments
improve
treatments.
addition,
manuscript
highlights
advantages
therapeutic
capabilities
use
nanoparticles
composed
different
biopolymers
various
conditions,
as
burns,
wound
healing,
prevention
scar
formation
during
treatment
dermal
infections,
pathologies
atopic
dermatitis.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(22), P. 16095 - 16095
Published: Nov. 8, 2023
Psoriasis
is
an
immune-mediated
disease
with
a
strong
genetic
component
that
brings
many
challenges
to
sick
individuals,
such
as
chronic
illness,
and
which
has
multiple
associated
comorbidities
like
cardiovascular
disease,
metabolic
syndrome,
inflammatory
bowel
psychological
disorders.
Understanding
the
interplay
between
innate
adaptative
immune
system
led
discovery
of
specific
cytokine
circuits
(Tumor
Necrosis
Factor-alpha
(TNF-α),
IL-23,
IL-17),
allowed
scientists
discover
new
biomarkers
can
be
used
predictors
treatment
response
pave
way
for
personalized
treatments.
In
this
review,
we
describe
footprint
psoriasis
leaves
on
skin
beyond,
key
pathophysiological
mechanisms,
current
available
therapeutic
options,
drawbacks
faced
by
existing
therapies,
anticipate
potential
future
perspectives
may
improve
quality
life
affected
individuals.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4801 - 4801
Published: March 2, 2023
The
need
for
safe,
therapeutically
effective,
and
patient-compliant
drug
delivery
systems
continuously
leads
researchers
to
design
novel
tools
strategies.
Clay
minerals
are
widely
used
in
products
both
as
excipients
active
agents
but,
recent
years,
there
has
been
a
growing
interest
research
aimed
at
the
development
of
new
organic
or
inorganic
nanocomposites.
attention
scientific
community
drawn
by
nanoclays,
thanks
their
natural
origin,
worldwide
abundance,
availability,
sustainability,
biocompatibility.
In
this
review,
we
focused
our
on
studies
inherent
pharmaceutical
biomedical
applications
halloysite
sepiolite,
semi-synthetic
synthetic
derivatives,
systems.
After
having
described
structure
materials
biocompatibility,
delineate
use
nanoclays
enhance
stability,
controlled
release,
bioavailability,
adsorption
properties
drugs.
Several
types
surface
functionalization
have
discussed,
showing
that
these
could
be
an
innovative
therapeutic
approach.
Pharmaceutical Research,
Journal Year:
2024,
Volume and Issue:
41(2), P. 263 - 279
Published: Jan. 23, 2024
Abstract
Introduction
Exosomes
are
extracellular
vesicles
in
the
range
of
40-150
nm
released
from
cell
membrane.
secreted
by
keratinocytes
can
communicate
with
other
and
immune
cells
specific
biomarkers
at
their
surface,
which
may
be
effective
on
inflammation
psoriasis
its
pathogenesis.
Objective
The
present
study
aimed
to
formulate
effectiveness
an
exosomal
delivery
system
tofacitinib
(TFC).
Methods
TFC
was
loaded
different
methods
exosomes
then
characterized
for
particle
size,
zeta
potential,
drug
loading
efficiency,
release
efficiency.
By
comparing
these
parameters,
probe
sonication
method
chosen
load
into
exosomes.
MTT
assay
used
compare
cytotoxicity
free
TFC-loaded
(TFC-Exo),
Real-time
PCR
determine
expression
levels
several
genes
involved
expressed
A-431
keratinocyte
suppression
after
treatment.
Animal
model
induced
BALB/c
mice
imiquimod
efficacy
TFC,
TFC-Exo
were
studies
macroscopic
appearance
histopathological
symptoms.
Results
encapsulating
showed
lower
assay,
higher
TNF-a,
IL-23,
IL-6
,
IL-15
real-time
better
therapeutic
effect
animal
models
compered
TFC.
Conclusions
This
enhancing
effects
reduction
side
favorably
chronic
administration.
Graphical
abstract
ChemMedChem,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Abstract
Lipid
nanoparticles
(LNPs)
have
emerged
as
a
transformative
platform
for
the
targeted
delivery
of
therapeutic
agents,
revolutionizing
treatment
paradigms
across
spectrum
diseases.
Since
inception
liposomes
in
1960s,
lipid‐based
nanotechnology
has
evolved
to
address
limitations
such
poor
bioavailability,
off‐target
effects,
and
instability,
thereby
enhancing
efficacy
safety
drug
administration.
This
review
highlights
latest
advancements
LNPs
technology,
focusing
on
their
application
cancer
therapy,
gene
infectious
disease
management,
glaucoma,
other
clinical
areas.
Recent
studies
underscore
potential
deliver
messenger
RNA
(mRNA)
small
interfering
(siRNA)
precise
genetic
intervention,
exemplified
by
breakthroughs
interference
CRISPR‐Cas9
genome
editing.
Additionally,
been
successfully
employed
ameliorate
conditions,
demonstrating
versatility
addressing
both
acute
chronic
disorders.
However,
challenges
persist
concerning
large‐scale
manufacturing,
long‐term
stability,
comprehensive
evaluations.
Future
research
must
focus
optimizing
formulations,
exploring
synergistic
combinations
with
existing
therapies,
expanding
scope
treatable
The
integration
into
personalized
medicine
exploration
applications
diseases
represent
promising
avenues
further
investigation.
are
poised
play
an
increasingly
central
role
development
next‐generation
therapeutics.
