Underestimated burden of per- and polyfluoroalkyl substances in global surface waters and groundwaters

Nature Geoscience, Journal Year: 2024, Volume and Issue: 17(4), P. 340 - 346

Published: April 1, 2024

Abstract Per- and polyfluoroalkyl substances (PFAS) are a class of fluorinated chemicals used widely in consumer industrial products. Their human toxicity ecosystem impacts have received extensive public, scientific regulatory attention. Regulatory PFAS guidance is rapidly evolving, with the inclusion wider range included advisories continued decrease what deemed safe concentrations. In this study we collated concentration data for over 45,000 surface groundwater samples from around world to assess global extent contamination their potential future environmental burden. Here show that substantial fraction sampled waters exceeds drinking water values, exceedance depending on jurisdiction source. Additionally, current monitoring practices probably underestimate environment given limited suite typically quantified but concern. An improved understanding embodied products required burden develop mitigation measures. While focus study, it also highlights society’s need better understand use, fate anthropogenic chemicals.

Language: Английский

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Suspect, Nontarget Screening, and Toxicity Prediction of Per- and Polyfluoroalkyl Substances in the Landfill Leachate

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(10), P. 4737 - 4750

Published: Feb. 26, 2024

Landfills are the final stage of urban wastes containing perfluoroalkyl and polyfluoroalkyl substances (PFASs). PFASs in landfill leachate may contaminate surrounding groundwater. As major environmental pollutants, emerging have raised global concern. Besides widely reported legacy PFASs, distribution potential toxic effects numerous remain unclear, unknown still need discovery characterization. This study proposed a comprehensive method for PFAS screening samples using suspect nontarget analysis. A total 48 from 10 classes were identified; nine novel including eight chloroperfluoropolyether carboxylates (Cl-PFPECAs) bistriflimide (HNTf2) first time leachate, where Cl-PFPECA-3,1 Cl-PFPECA-2,2 media. Optimized molecular docking models established prioritizing with activity against peroxisome proliferator-activated receptor α estrogen α. Our results indicated that several

Language: Английский

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Binding Affinity and Mechanism of Six PFAS with Human Serum Albumin: Insights from Multi-Spectroscopy, DFT and Molecular Dynamics Approaches

Toxics, Journal Year: 2024, Volume and Issue: 12(1), P. 43 - 43

Published: Jan. 5, 2024

Per- and Polyfluoroalkyl Substances (PFAS) bioaccumulate in the human body, presenting potential health risks cellular toxicity. Their transport mechanisms interactions with tissues circulatory system require further investigation. This study investigates interaction of six PFAS Human Serum Albumin (HSA) using multi-spectroscopy, DFT a molecular dynamics approach. Multi-spectral analysis shows that perfluorononanoic acid (PFNA) has best binding capabilities HSA. The order constants (298 K) is as follows: "Perfluorononanoic Acid (PFNA, 7.81 × 10

Language: Английский

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Associations between serum per- and polyfluoroalkyl substances as mixtures and lipid levels: A cross-sectional study in Jinan

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 923, P. 171305 - 171305

Published: Feb. 27, 2024

Language: Английский

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Hepatic concentrations of per- and polyfluoroalkyl substances (PFAS) in dolphins from south-east Australia: Highest reported globally

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168438 - 168438

Published: Nov. 12, 2023

Per- and polyfluoroalkyl substances (PFAS) concentrations were investigated in hepatic tissue of four dolphin species stranded along the south-east coast Australia between 2006 2021; Burrunan (Tursiops australis), common bottlenose truncatus), Indo-Pacific aduncus), short-beaked (Delphinus delphis). Two populations represented dataset have highest reported global population ∑25PFAS (Port Phillip Bay median 9750 ng/g ww, n = 3, Gippsland Lakes 3560 8), which 50–100 times higher than other here; (50 9), (80 1), (61 12). Also included results is individual (19,500 ww) PFOS (18,700 concentrations, at almost 30 % any Cetacea globally. Perfluorooctane sulfonate (PFOS) was above method reporting limits for all samples (range; 5.3–18,700 ww), constituted contribution to overall ∑PFAS burdens with 47 99 profile across dataset. The exceed published tentative critical (677–775 ng/g) 42 dolphins 90 critically endangered dolphin. This research reports first time novel emerging PFASs such as 6:2 Cl-PFESA, PFMPA, PFEECH FBSA marine mammals southern hemisphere, high detection rates It study show occurrence PFAS tissues multiple from Australasian region, demonstrating inshore dolphins. Finally, it provides key baseline knowledge potential exposure bioaccumulation compounds within coastal environment Australia.

Language: Английский

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Exploring the environmental contamination toxicity and potential carcinogenic pathways of perfluorinated and polyfluoroalkyl substances (PFAS): an integrated network toxicology and molecular docking strategy

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e37003 - e37003

Published: Aug. 28, 2024

The objective of this study was to investigate the potential carcinogenic toxicity and mechanisms PFAS in thyroid, renal, testicular cancers base on network toxicology molecular docking techniques. Structural modeling performed predict relevant information, compounds cancer-related targets were screened multiple databases. interaction with three their key protein explored by combining analysis, enrichment analysis PFOA, PFOS, PFHXS exhibited significant cytotoxic effects. These may induce cancer mediating active oxygen metabolism transduction phosphatidylinositol 3-kinase/protein kinase B signaling pathway through genes such as ALB, mTOR, MDM2, ERBB2. Furthermore, underlying toxic be linked pathways cancer, chemical carcinogenesis reactive species/receptor activation, FoxO pathway. results contribute a comprehensive understanding effects these environmental pollutants genes, proteins, metabolic living organisms. It revealed inducing cancers, provided solid theoretical foundation for designing new control strategies drug screening initiatives. Additionally, integrated application technology can enhance our unknown pollutants, which is beneficial protecting environment human health.

Language: Английский

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Forever but not everywhere? Unexpected non‐detection of per‐ and polyfluoroalkyl substances (PFAS) in major Philippines rivers

River, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Abstract Recent studies suggest per‐ and polyfluoroalkyl substances (PFAS) are ubiquitous in rivers worldwide. In the Asia‐Pacific region, frequency of PFAS detection is increasing. However, overwhelming majority data represent high population urbanized river catchments. this study, we investigate occurrence major Philippines systems characterized by both low densities. Pasig Laguna de Bay River, which drains a urban conurbation, detected at concentrations typical global rivers. Unexpectedly, did not detect water or sediments density catchments, despite our instrument limits being lower than vast reported We hypothesize that septic tanks, as dominant wastewater treatment practice may control release into groundwater Philippines. no currently exist to validate supposition. More broadly, findings highlight need for more representative sampling analysis accurately regional frequencies trends.

Language: Английский

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One-step synthesis of reduced graphene oxide/activated carbon composite for efficient removal of per- and polyfluoroalkyl substances from drinking water: Adsorption mechanisms and DFT study

Separation and Purification Technology, Journal Year: 2025, Volume and Issue: unknown, P. 132797 - 132797

Published: April 1, 2025

Language: Английский

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Thermochemical Recycling and Degradation Strategies of Halogenated Polymers (F−, Cl−, Br−): A Holistic Review Coupled with Mechanistic Insights

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Handling the waste associated with halogenated polymers is a daunting task due to well‐documented emission of halogen‐bearing toxicants during disposal or recycling operation. According Stockholm Convention treaty, most these products are classified as persistent organic pollutants their potential health hazards. This review aims provide holistic overview recent updates for treating polymeric through physical, chemical and biological approaches. In line inquiry, critical analysis obstacles prospects each degradation technique on polymer has been performed, assessing based efficiency, treatment upscaling, pollution control, feasibility. Though many treatments show promising results, they also entail drawbacks. Thermal exploiting various metal oxides, especially calcium additives, considered executable valorization coupled mineralization/metal extraction its intuitive operational feasibility scalability. Strategies combating soaring wastes summarized herein tap into promoting circular economy approach sustainable

Language: Английский

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Fate Variations of Per- and Polyfluoroalkyl Substances in Diverse Aquatic Environments: An Overlooked Influence of Hydrodynamics

Water Research, Journal Year: 2025, Volume and Issue: unknown, P. 123628 - 123628

Published: April 1, 2025

Language: Английский

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