Challenges and Strategies for Bioavailability of Curcumin DOI
Mikael Kélvin de Albuquerque Mendes,

Christian Bremmer dos Santos Oliveira,

Carla Mariana da Silva Medeiros

et al.

Published: Jan. 1, 2023

Phytochemicals have been highlighted in several sectors of industry due to their different biological activities. In fact, the curcumin is a polyphenol extracted from rhizome turmeric (Curcuma longa) consumed form kitchen spices since ancient times which it has demonstrated beneficial health effects such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-tumor, and so on. However, concentration bloodstream very low its high hydrophobicity, absorption intestinal physiological conditions, metabolism rate liver, rapid excretion by gallbladder. Poor bioavailability limited bioactivity phytochemical. Efforts made improve upon this using chemical modification encapsulation approaches. Considering versatility, safety, biocompatibility, technologies more effective improved dispersibility, stability, bioavailability, phytochemicals vivo vitro assays. Therefore, chapter focused on aspects involved (e.g., solubility, food matrix effects) phytochemical with great potential for cancer neurodegenerative diseases chemopreventive effect. We also strategies used enhance based resulting nanoparticle drug delivery systems. The topic discussed here should contribute research related approaches other improving and, consequently, human conditions.

Language: Английский

Evaluation of antimicrobial photodynamic activity of CuminUP60®- A commercially-available high-soluble curcumin DOI Creative Commons

Fang Xu,

Jiamiao Hu, Natthida Sriboonvorakul

et al.

LWT, Journal Year: 2024, Volume and Issue: 205, P. 116490 - 116490

Published: July 14, 2024

Curcumin, a polyphenol extracted from Curcuma longa L. with variety of biological and pharmacological activities, has been identified as promising photosensitizer for food sterilization. However, its low aqueous solubility bioavailability greatly restrict the practical application curcumin. In last decades, number approaches have proposed to address this challenge, several having already attained notable commercial viability. CuminUP60®, patented curcumin complex consisting extract Poloxam407, gathered attention in realms enhanced solubility, therapeutic potential. antimicrobial photodynamic activity novel not investigated. current study, we found that CuminUP60® showed maximum absorption intensity at 434 nm capability produce Reactive Oxygen Species (ROS) upon blue light excitation. Furthermore, desirable bactericidal against range typical foodborne bacteria including Staphylococcus aureus, Listeria monocytogenes Vibrio parahaemolyticus, Shewanella putrefaciens, Pseudomonas fluorescens (MIC = 83.33 μM) Escherichia coli 166.66 (5.3 mW/cm2) illumination 30 min. Taken together, results demonstrated possess antibacterial activity, which could provide crucial support development industrially applicable sterilization systems within industry.

Language: Английский

Citations

3
Food additives as photosensitizers: A systematic review and narrative synthesis DOI

Wanzhen Dai,

Jiamiao Hu, Bee K. Tan

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 464, P. 141925 - 141925

Published: Nov. 6, 2024

Language: Английский

Citations

3
Oil-Based Curcuminoid Phospholipid Formulation Mimicking Natural Digestion Enhances Oral Bioavailability of Curcuminoids in Healthy Subjects DOI
Tanja Wagner, Roland Wacker, Thomas A. Klein

et al.

Journal of Medicinal Food, Journal Year: 2024, Volume and Issue: 27(5), P. 396 - 403

Published: April 30, 2024

Curcumin, the fat-soluble active ingredient and major compound of curcuminoids contained in curcuma root, is known for its physiological low absorption bioavailability. Various formulations galenic technologies are currently available on market. In this study, product tested was provided as a soft gelatin capsule containing an oily matrix mixed with phospholipids (oil/phospholipids [PL]-based, no new applied or artificial excipients added). This intended to improve bioavailability well mimic natural digestion process substances. particular, oral oil/PL-based formulation compared pure extract alone (reference product), randomized, cross-over, single dose study design. Twelve healthy subjects were administered 200 mg under fasting conditions. Pharmacokinetic parameters analyzed from individual concentration-time curves total curcuminoids, curcumin metabolite tetrahydrocurcumin (THC). Results showed significantly higher AUC

Language: Английский

Citations

1
Boosting Curcumin Bioavailability with Egg White Protein Aerogels: A Sustainable Supercritical CO₂-Based Approach for Enhanced Bioaccessibility, Antioxidant Activity, and Anti-Inflammatory Effects DOI Creative Commons
Farhad Alavi, Ozan N. Ciftci

Future Foods, Journal Year: 2024, Volume and Issue: unknown, P. 100532 - 100532

Published: Dec. 1, 2024

Language: Английский

Citations

1
Boosting Curcumin Bioavailability with Egg White Protein Aerogels: A Sustainable Supercritical Co2-Based Approach for Enhanced Bioaccessibility, Antioxidant Activity, and Anti-Inflammatory Effects DOI
Farhad Alavi, Ozan N. Ciftci

Published: Jan. 1, 2024

Language: Английский

Citations

0
Challenges and Strategies for Bioavailability of Curcumin DOI
Mikael Kélvin de Albuquerque Mendes,

Christian Bremmer dos Santos Oliveira,

Carla Mariana da Silva Medeiros

et al.

Published: Jan. 1, 2023

Phytochemicals have been highlighted in several sectors of industry due to their different biological activities. In fact, the curcumin is a polyphenol extracted from rhizome turmeric (Curcuma longa) consumed form kitchen spices since ancient times which it has demonstrated beneficial health effects such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-tumor, and so on. However, concentration bloodstream very low its high hydrophobicity, absorption intestinal physiological conditions, metabolism rate liver, rapid excretion by gallbladder. Poor bioavailability limited bioactivity phytochemical. Efforts made improve upon this using chemical modification encapsulation approaches. Considering versatility, safety, biocompatibility, technologies more effective improved dispersibility, stability, bioavailability, phytochemicals vivo vitro assays. Therefore, chapter focused on aspects involved (e.g., solubility, food matrix effects) phytochemical with great potential for cancer neurodegenerative diseases chemopreventive effect. We also strategies used enhance based resulting nanoparticle drug delivery systems. The topic discussed here should contribute research related approaches other improving and, consequently, human conditions.

Language: Английский

Citations

0