The protection of bisphenol A-modulated miRNAs and targets by natural products

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109299 - 109299

Published: Jan. 1, 2025

Bisphenol A (BPA) is a ubiquitous environmental pollutant with endocrine-disrupting functions. Identifying protective drugs and exploring the mechanisms against BPA are crucial in healthcare. Natural products exhibiting antioxidant properties considered to be able protect toxicity. Although BPA-modulated targets miRNAs have been individually reported, their connections natural were rarely organized. With help of protein-protein interaction database (STRING), relationship between individual was interconnected provide systemic view. In this review, BPA-downregulated -upregulated classified, interactive network innovatively analyzed using bioinformatic (STRING). also retrieved ingeniously connected targets. Moreover, novel connection BPA-countering integrated into All these targets-associated and/or incorporated STRING network, providing relationships. Overall, target-miRNA-protecting product axis constructed, straightforward direction for effects products.

Language: Английский

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Parental BPA Exposure Disrupts Offspring Transcriptomic Profiles and Impairs Embryonic Lineage Specification during Zygotic Genome Activation

Journal of Hazardous Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 100146 - 100146

Published: Feb. 1, 2025

Language: Английский

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Beyond Cholesterol: Emerging Risk Factors in Atherosclerosis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2352 - 2352

Published: March 29, 2025

Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, traditionally linked to elevated cholesterol levels, particularly low-density lipoprotein (LDL-C). However, despite aggressive lipid-lowering strategies, residual risk persists, underscoring the need explore additional contributing factors. This review examines emerging factors beyond cholesterol, including chronic inflammation, gut microbiota composition, oxidative stress, environmental exposures. Inflammation plays pivotal role in atherogenesis, with markers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) serving indicators disease activity. The microbiome, metabolites like trimethylamine N-oxide (TMAO), has been implicated vascular inflammation plaque development, while beneficial short-chain fatty acids (SCFAs) demonstrate protective effects. Oxidative stress further exacerbates endothelial dysfunction instability, driven by reactive oxygen species (ROS) lipid peroxidation. Additionally, factors, air pollution, heavy metal exposure, endocrine disruptors, psychological have emerged significant contributors disease. Understanding these novel offers broader perspective on atherosclerosis pathogenesis provides new avenues for targeted prevention therapeutic interventions.

Language: Английский

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Multi-mechanistic effects of bisphenol A on testicular dysfunction and endocrine disruption in adult male Labeo bata: oxidative stress, inflammation, and dysregulated energy sensors

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126231 - 126231

Published: April 1, 2025

Language: Английский

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Exploring the toxicological impact of bisphenol a exposure on psoriasis through network toxicology, machine learning, and multi-dimensional bioinformatics analysis

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 385, P. 125708 - 125708

Published: May 10, 2025

Language: Английский

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