The Prostate,
Journal Year:
2024,
Volume and Issue:
84(7), P. 666 - 681
Published: March 5, 2024
Abstract
Background
Chronic
prostatitis
and
chronic
pelvic
pain
syndrome
(CP/CPPS)
leads
to
severe
discomfort
in
males
loss
of
sperm
quality.
Current
therapeutic
options
have
failed
achieve
satisfactory
results.
Sodium
butyrate
(NaB)
plays
a
beneficial
role
reducing
inflammation,
increasing
antioxidant
capacities,
improving
organ
dysfunction;
additionally
NaB
has
good
safety
prospects
great
potential
for
clinical
application.
The
purpose
the
current
research
was
study
effect
on
CP/CPPS
underlying
mechanisms
using
mouse
model
experimental
autoimmune
(EAP)
mice.
Methods
EAP
successfully
established
by
subcutaneously
injecting
mixture
prostate
antigen
complete
Freund's
adjuvant.
Then,
mice
received
daily
intraperitoneal
injections
(100,
200,
or
400
mg/kg/day)
16
days,
from
Days
26
42.
We
then
explored
anti‐inflammatory
studying
effects
Nrf2
inhibitor
ML385
HO‐1
zinc
protoporphyrin
inflammation
this
model.
On
Day
42,
hematoxylin‐eosin
staining
dihydroethidium
were
used
evaluate
histological
changes
oxidative
stress
levels
tissues.
assessed
applying
Von
Frey
filaments
lower
abdomen.
inflammation‐related
cytokines,
such
as
interleukin
(IL)−1β,
IL‐6,
tumor
necrosis
factor
detected
enzyme‐linked
immunosorbent
assay.
regulation
Nrf2/HO‐1
signaling
pathway
expression
NLRP3
inflammasome‐related
protein
western
blot
analysis
Results
Compared
with
group,
development,
manifestations,
cytokine
showed
that
reduced
severity
EAP.
treatment
could
inhibit
inflammasome
activation.
Mechanism
studies
intervention
alleviate
through
signal
pathway.
inhibitors
can
‐mediated
stress.
inhibitory
activation
also
be
blocked
Conclusions
alleviates
prostatic
associated
inhibiting
via
an
effective
agent
Current Drug Targets,
Journal Year:
2024,
Volume and Issue:
25(8), P. 543 - 557
Published: May 6, 2024
Ferroptosis
is
implicated
in
the
pathogenesis
of
multiple
diseases,
including
neurodegenerative
cardiovascular
kidney
pathologies,
ischemia-reperfusion
injury,
and
cancer.
The
current
review
article
highlights
involvement
ferroptosis
traumatic
brain
acute
damage,
ethanol-induced
liver
PM2.5-induced
lung
injury.
Melatonin,
a
molecule
produced
by
pineal
gland
many
other
organs,
well
known
for
its
anti-
aging,
anti-inflammatory,
anticancer
properties
used
treatment
different
diseases.
Melatonin's
ability
to
activate
anti-ferroptosis
pathways
sirtuin
(SIRT)6/p-
nuclear
factor
erythroid
2-related
2
(Nrf2),
Nrf2/
antioxidant
responsive
element
(ARE)/
heme
oxygenase
(HO-1)/SLC7A11/glutathione
peroxidase
(GPX4)/
prostaglandin-endoperoxide
synthase
(PTGS2),
extracellular
signal-regulated
kinase
(ERK)/Nrf2,
ferroportin
(FPN),
Hippo/
Yes-associated
protein
(YAP),
Phosphoinositide
3-kinase
(PI3K)/
B
(AKT)/
mammalian
target
rapamycin
(mTOR)
SIRT6/
receptor
coactivator
4
(NCOA4)/
ferritin
heavy
chain
1
(FTH1)
signaling
suggests
that
it
could
serve
as
valuable
therapeutic
agent
preventing
cell
death
associated
with
various
Further
research
needed
fully
understand
precise
mechanisms
which
melatonin
regulates
potential
target.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 17, 2022
Acute
kidney
injury
(AKI),
one
of
the
most
prevalent
clinical
diseases
with
a
high
incidence
rate
worldwide,
is
characterized
by
rapid
deterioration
renal
function
and
further
triggers
accumulation
metabolic
waste
toxins,
leading
to
complications
dysfunction
other
organs.
Multiple
pathogenic
factors,
such
as
rhabdomyolysis,
infection,
nephrotoxic
medications,
ischemia-reperfusion
injury,
contribute
onset
progression
AKI.
However,
detailed
mechanism
remains
unclear.
Ferroptosis,
recently
identified
nonapoptotic
cell
death,
iron-dependent
caused
lipid
peroxide
in
cells.
A
variety
studies
have
demonstrated
that
ferroptosis
plays
significant
role
AKI
development,
contrast
forms
apoptosis,
necroptosis,
pyroptosis.
In
this
review,
we
systemically
summarized
definition,
primary
biochemical
mechanisms,
key
regulators
associated
pharmacological
research
progress
We
discussed
its
therapeutic
potential
for
prevention
AKI,
hope
providing
useful
reference
basic
studies.
The Prostate,
Journal Year:
2024,
Volume and Issue:
84(7), P. 666 - 681
Published: March 5, 2024
Abstract
Background
Chronic
prostatitis
and
chronic
pelvic
pain
syndrome
(CP/CPPS)
leads
to
severe
discomfort
in
males
loss
of
sperm
quality.
Current
therapeutic
options
have
failed
achieve
satisfactory
results.
Sodium
butyrate
(NaB)
plays
a
beneficial
role
reducing
inflammation,
increasing
antioxidant
capacities,
improving
organ
dysfunction;
additionally
NaB
has
good
safety
prospects
great
potential
for
clinical
application.
The
purpose
the
current
research
was
study
effect
on
CP/CPPS
underlying
mechanisms
using
mouse
model
experimental
autoimmune
(EAP)
mice.
Methods
EAP
successfully
established
by
subcutaneously
injecting
mixture
prostate
antigen
complete
Freund's
adjuvant.
Then,
mice
received
daily
intraperitoneal
injections
(100,
200,
or
400
mg/kg/day)
16
days,
from
Days
26
42.
We
then
explored
anti‐inflammatory
studying
effects
Nrf2
inhibitor
ML385
HO‐1
zinc
protoporphyrin
inflammation
this
model.
On
Day
42,
hematoxylin‐eosin
staining
dihydroethidium
were
used
evaluate
histological
changes
oxidative
stress
levels
tissues.
assessed
applying
Von
Frey
filaments
lower
abdomen.
inflammation‐related
cytokines,
such
as
interleukin
(IL)−1β,
IL‐6,
tumor
necrosis
factor
detected
enzyme‐linked
immunosorbent
assay.
regulation
Nrf2/HO‐1
signaling
pathway
expression
NLRP3
inflammasome‐related
protein
western
blot
analysis
Results
Compared
with
group,
development,
manifestations,
cytokine
showed
that
reduced
severity
EAP.
treatment
could
inhibit
inflammasome
activation.
Mechanism
studies
intervention
alleviate
through
signal
pathway.
inhibitors
can
‐mediated
stress.
inhibitory
activation
also
be
blocked
Conclusions
alleviates
prostatic
associated
inhibiting
via
an
effective
agent
