Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
276, P. 116340 - 116340
Published: April 17, 2024
Exposure
to
pesticides
induces
oxidative
stress
and
deleterious
effects
on
various
tissues
in
non-target
organisms.
Numerous
models
investigating
pesticide
exposure
have
demonstrated
metabolic
disturbances
such
as
imbalances
amino
acid
levels
within
the
organism.
One
potentially
effective
strategy
mitigate
toxicity
involves
dietary
intervention
by
supplementing
exogenous
acids
their
derivates
augment
body's
antioxidant
capacity
pesticide-induced
harm,
whose
mechanism
including
bolstering
glutathione
synthesis,
regulating
arginine-NO
metabolism,
mitochondria-related
stress,
open
of
ion
channels,
well
enhancing
intestinal
microecology.
Enhancing
synthesis
through
supplementation
substrates
N-acetylcysteine
glycine
is
regarded
a
potent
achieve
this.
Selection
appropriate
or
for
supplementation,
determining
an
dosage,
are
utmost
importance
mitigation
harm.
More
experimentation
required
that
large
population
samples
validate
efficacy
strategies,
determine
long-term
low-dose
exposure.
This
review
provides
insights
guide
future
research
aimed
at
preventing
alleviating
derivates.
Medicine,
Journal Year:
2025,
Volume and Issue:
104(16), P. e42132 - e42132
Published: April 18, 2025
Sepsis
is
a
life-threatening
condition
characterized
by
organ
dysfunction
resulting
from
dysregulated
host
immune
response
to
infection.
It
associated
with
high
incidence,
intricate
pathophysiological
mechanisms,
and
rapidly
progressive
severity,
rendering
it
leading
cause
of
mortality
among
patients
in
intensive
care
units.
The
Nuclear
Factor
Erythroid
2-Related
2
(Nrf2)
transcription
factor
pivotal
for
maintaining
cellular
redox
homeostasis
regulating
the
expression
antioxidant
cytoprotective
genes.
Emerging
evidence
suggests
that
activation
Nrf2
signaling
pathway
attenuates
sepsis-induced
inflammatory
responses,
oxidative
stress,
dysfunction,
thereby
improving
clinical
outcomes.
These
findings
underscore
potential
as
therapeutic
target,
offering
promising
avenue
development
novel
interventions
aimed
at
mitigating
complications
prognosis
sepsis.
Frontiers in Molecular Neuroscience,
Journal Year:
2024,
Volume and Issue:
17
Published: Dec. 11, 2024
As
many
proteins
prioritize
functionality
over
constancy
of
structure,
a
proteome
is
the
shortest
stave
in
Liebig's
barrel
cell
sustainability.
In
this
regard,
both
prokaryotes
and
eukaryotes
possess
abundant
machinery
supporting
quality
healthy
stressful
conditions.
This
machinery,
namely
chaperones,
assists
folding,
refolding,
utilization
client
proteins.
The
functions
chaperones
are
especially
important
for
brain
cells,
which
highly
sophisticated
terms
structural
functional
organization.
Molecular
known
to
exert
beneficial
effects
diseases
including
one
most
threatening
widespread
pathologies,
ischemic
stroke.
However,
whether
how
they
antioxidant
defense
stroke
remains
unclear.
Herein,
we
discuss
shown
fight
oxidative
stress
mechanisms
their
action.
stroke,
during
intense
production
free
radicals,
molecular
preserve
by
interacting
with
oxidized
proteins,
regulating
imbalanced
mitochondrial
function,
directly
fighting
stress.
For
instance,
cells
recruit
Hsp60
Hsp70
provide
proper
folding
newly
synthesized
proteins-these
factors
required
early
response
refold
damaged
polypeptides.
Additionally,
upregulates
some
dedicated
pathways
such
as
FOXO3
signaling.
Small
HSPs
decrease
via
attenuation
function
through
involvement
regulation
Nrf-
(Hsp22),
Akt
Hippo
(Hsp27)
signaling
well
mitophagy
(Hsp27,
Hsp22).
A
similar
has
also
been
proposed
Sigma-1
receptor,
contributing
function.
Some
can
prevent
excessive
formation
reactive
oxygen
species
whereas
Hsp90
suggested
be
responsible
pro-oxidant
Finally,
heat-resistant
obscure
(Hero)
able
shield
thus
preventing
possible
oxidation.
Journal of Cerebral Blood Flow & Metabolism,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Strokes
constitute
over
50%
of
all
neurological
diseases,
standing
as
the
foremost
cause
physical
and
mental
disability.
Currently,
there
are
no
widely
accepted
gold
standard
treatments
for
ischemic
strokes
beyond
intravenous
thrombolysis
mechanical
thrombectomy
applied
during
acute
therapeutic
window.
Therefore,
need
novel
targeting
crucial
signaling
mediators
involved
in
stroke
is
utmost
importance.
The
sigma-1
receptor
(S1R),
a
molecular
chaperone
located
at
mitochondria-associated
endoplasmic
reticulum
membranes
(MAM),
has
exhibited
neuroprotective
effects
when
modulated
by
synthetic
endogenous
agents
across
various
cerebrovascular
diseases.
In
this
review,
we
describe
emerging
role
S1R
agonists
antagonists
regulating
blood-brain
barrier
(BBB)
dysfunction,
neuroinflammation,
neurocognitive
impairment
following
stroke.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 3, 2024
Abstract
Sepsis,
one
of
the
leading
causes
death
in
critically
ill
patients,
is
characterized
by
multiple
organ
dysfunction
caused
dysregulated
immune
response
to
infection.
Hence,
we
investigated
that
effects
CSN6
sepsis
and
underlying
mechanism.
RAW264.7
cell
inducted
with
lipopolysaccharide
(LPS)
adenosine
triphosphate
(ATP).
protein
expression
macrophage
vitro
model
was
increased.
We
collected
10
patients
single
analysis
expression.
aggravated
inflammation
sepsis.
ferroptosis
mitochondrial
damage
induced
MIF
inhibitor
reduced
on
at
11-ARG,
21-ARG,
31-LEU,
32-ASP
linked
280-ASN,
366-SER.In
conclusion,
aggravates
myocardial
injury
signaling,
suggesting
targeting
this
mechanism
may
be
a
feasible
strategy
anti-inflammation
for
or
sepsis-induced
injury.
