Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(7), P. 1424 - 1424
Published: July 6, 2022
Most
living
organisms
in
both
the
plant
and
animal
kingdoms
have
evolved
processes
to
stay
tune
with
alternation
of
day
night,
optimize
their
physiology
as
a
function
light
supply.
In
mammals,
circadian
clock
relying
on
feedback
loops
between
key
transcription
factors
will
thus
control
temporally
regulated
pattern
expression
most
genes.
Modern
ways
life
highly
altered
synchronization
human
activities
clocks.
This
review
discusses
links
an
rise
pathologies.
We
then
sum
up
proofs
concept
advocating
for
integration
considerations
chronotherapy
health
care,
medicine,
pharmacotherapy.
Finally,
we
discuss
current
challenges
that
biology
must
face
tools
address
them.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(24), P. 17198 - 17198
Published: Dec. 6, 2023
The
current
understanding
of
long
COVID
(LC)
is
still
limited.
This
review
highlights
key
findings
regarding
the
role
gut
microbiota,
mitochondria,
and
main
pathophysiological
aspects
LC
revealed
by
clinical
studies,
related
to
complex
interplay
between
infection,
intestinal
dysbiosis,
dysfunctional
systemic
inflammation
generated
in
a
vicious
circle,
reflecting
molecular
cellular
processes
from
"leaky
gut"
electron
transport
chain
(ETC)"
into
quantum
leap.
heterogeneity
has
hindered
progress
deciphering
all
mechanisms,
therefore,
approach
must
be
multidisciplinary,
with
special
focus
not
only
on
symptomatic
management
but
also
addressing
underlying
health
problems
patients.
It
imperative
further
assess
validate
effects
COVID-19
microbiome
their
relationship
infections
other
viral
agents
or
pathogens.
Further
studies
are
needed
better
understand
expand
interdisciplinary
points
view
that
required
accurately
diagnose
effectively
treat
this
heterogeneous
condition.
Given
ability
SARS-CoV-2
induce
autoimmunity
susceptible
patients,
they
should
monitored
for
symptoms
autoimmune
disease
after
contracting
infection.
One
question
remains
open,
namely,
whether
various
vaccines
developed
end
pandemic
will
autoimmunity.
Recent
data
highlighted
have
persistence
mitochondria
organs
such
as
heart
and,
lesser
extent,
kidneys,
liver,
lymph
nodes,
organism
been
able
clear
virus
lungs,
could
an
explanation
LC.
Applied Sciences,
Journal Year:
2022,
Volume and Issue:
12(8), P. 4084 - 4084
Published: April 18, 2022
Post-COVID
syndrome
is
characterized
by
the
persistence
of
nonspecific
disabling
symptoms,
even
several
months
after
resolution
infection,
with
clinical
characteristics
similar
to
fibromyalgia
(FM)
and
a
prevalence
31%.
We
evaluated
effectiveness
physical
exercise,
in
association
L-acetyl-carnitine
(ALC)
therapy,
patients
syndrome,
on
musculoskeletal
pain,
dyspnea,
functional
capacity,
quality
life,
depression.
conducted
an
observational
case-control
study
syndrome.
The
were
randomly
divided
into
two
groups:
treatment
group
that
received
rehabilitation
combination
ALC
500
mg
therapy;
control
only
treatment.
Patients
assessed
at
time
recruitment
(T0)
one
month
end
therapy
(T1),
administration
rating
scales:
NRS,
Barthel
Dyspnea
Index
(NPI),
12-Item
Short
Form
Survey
(SF-12)
scale,
Fibromyalgia
Impact
Questionnaire
(FIQ),
Patient
Health
(PHQ-9).
showed
statistically
higher
variations
pain
scores,
No
significant
differences
between
groups
emerged
regarding
changes
dyspnea
capacity
scores.
Combining
exercise
promising
effective
management
especially
for
depression,
life.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: May 30, 2024
Lung
adenocarcinoma
(LUAD)
is
the
most
common
and
aggressive
subtype
of
lung
cancer,
coronavirus
disease
2019
(COVID-19)
has
become
a
serious
public
health
threat
worldwide.
Patients
with
LUAD
COVID-19
have
poor
prognosis.
Therefore,
finding
medications
that
can
be
used
to
treat
COVID-19/LUAD
patients
essential.
Bioinformatics
analysis
was
identify
20
possible
metformin
target
genes
for
treatment
COVID-19/LUAD.
PTEN
mTOR
may
serve
as
hub
metformin.
Metformin
able
cure
comorbidity
through
energy
metabolism,
oxidoreductase
NADH
activity,
FoxO
signalling
pathway,
AMPK
system,
among
other
pathways,
according
results
bioinformatic
research.
ability
inhibit
proliferation
A549
cells,
colony
formation
assays.
In
increased
glucose
uptake
lactate
generation,
while
decreasing
ATP
synthesis
NAD
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(7), P. 1424 - 1424
Published: July 6, 2022
Most
living
organisms
in
both
the
plant
and
animal
kingdoms
have
evolved
processes
to
stay
tune
with
alternation
of
day
night,
optimize
their
physiology
as
a
function
light
supply.
In
mammals,
circadian
clock
relying
on
feedback
loops
between
key
transcription
factors
will
thus
control
temporally
regulated
pattern
expression
most
genes.
Modern
ways
life
highly
altered
synchronization
human
activities
clocks.
This
review
discusses
links
an
rise
pathologies.
We
then
sum
up
proofs
concept
advocating
for
integration
considerations
chronotherapy
health
care,
medicine,
pharmacotherapy.
Finally,
we
discuss
current
challenges
that
biology
must
face
tools
address
them.
