The FASEB Journal,
Journal Year:
2024,
Volume and Issue:
38(20)
Published: Oct. 24, 2024
LC3-associated
phagocytosis
(LAP)
is
a
distinct
type
of
autophagy
that
involves
the
sequestration
extracellular
material
by
phagocytes.
Beyond
removal
dead
cells
and
cellular
debris
from
eukaryotic
cells,
LAP
also
involved
in
variety
pathogens,
including
bacteria,
fungi,
viruses.
These
events
are
integral
to
multiple
physiological
pathological
processes,
such
as
host
defense,
inflammation,
tissue
homeostasis.
Dysregulation
has
been
associated
with
pathogenesis
several
human
diseases,
infectious
autoimmune
neurodegenerative
diseases.
Thus,
understanding
molecular
mechanisms
underlying
its
involvement
diseases
may
provide
new
insights
into
development
novel
therapeutic
strategies
for
these
conditions.
In
this
review,
we
summarize
highlight
current
consensus
on
role
biological
functions
disease
progression
propose
strategies.
Further
studies
needed
illustrate
precise
determine
targets
LAP-associated
pathologies.
Egyptian Rheumatology and Rehabilitation,
Journal Year:
2023,
Volume and Issue:
50(1)
Published: July 27, 2023
Abstract
Background
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disorder.
Autophagy,
regulator
of
cell
homeostasis,
can
impact
innate
and
adaptive
immune
cells
activation
contribute
to
the
pathogenesis
RA.
The
purpose
this
study
was
assess
significance
autophagy
in
RA,
by
investigating
signaling
Beclin-1
RA
patients.
Results
In
patients,
gene
expression
level
higher
than
healthy
controls
with
statistically
highly
significant
difference
(
P
<
0.
001)
where
mean
3.33
±
0.45
patients
0.98
0.070
controls.
There
positive
correlation
between
disease
duration
p
=
0.013*),
erythrocyte
sedimentation
rate
(ESR),
C-reactive
protein
(CRP),
rheumatoid
factor
(RF)
titer
0.018*,
0.027*,
0.023*
respectively).
overexpression
significantly
correlated
activity
parameters
(DAS
28,
patient
physician
global
health
assessment).
Furthermore,
disability
index,
Modified
Health
Assessment
Questionnaire
(MHAQ)
0.001).
Conclusion
elevated
autophagy-related
probability,
high
activity,
severity.
Therefore,
suppressing
may
be
therapeutic
target
for
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: March 22, 2024
Background
Many
observational
studies
have
been
reported
that
patients
with
autoimmune
or
allergic
diseases
seem
to
a
higher
risk
of
developing
senile
cataract,
but
the
views
are
not
consistent.
In
order
minimize
influence
reverse
causality
and
potential
confounding
factors,
we
performed
Mendelian
Randomization
(MR)
analysis
investigate
genetic
causal
associations
between
autoimmune,
cataract.
Methods
Single
nucleotide
polymorphisms
associated
ten
common
were
obtained
from
IEU
Open
genome-wide
association
(GWAS)
database.
Summary-level
GWAS
statistics
for
clinically
diagnosed
cataract
FinnGen
research
project
GWAS,
which
consisted
59,522
individuals
cataracts
312,864
control
individuals.
MR
was
conducted
using
mainly
inverse
variance
weighted
(IVW)
method
further
sensitivity
test
robustness.
Results
As
diseases,
IVW
results
confirmed
type
1
diabetes
(OR
=
1.06;
95%
CI
1.05-1.08;
p
2.24×10
-12
),
rheumatoid
arthritis
1.05;
1.02-1.08;
1.83×10
-4
hypothyroidism
2.4;
1.42-4.06;
1.12×10
-3
systemic
lupus
erythematosus
1.02;
1.01-1.03;
2.27×10
asthma
1.2×10
)
rhinitis
1.07;
1.02-1.11;
2.15×10
correlated
Celiac
disease
1.04;
1.01-1.08;
P
0.0437)
atopic
dermatitis
1.01-1.10;
0.0426)
exhibited
suggestive
connection
after
Bonferroni
correction.
These
consistent
across
median
Egger
methods,
similar
estimates
in
direction
magnitude.
Sensitivity
proved
these
reliable.
Conclusions
The
showed
there
relationships
diabetes,
arthritis,
hypothyroidism,
erythematosus,
asthma,
To
clarify
possible
role
allergy
pathophysiology
needed.
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 1165 - 1181
Published: May 1, 2024
Autophagy
is
recognized
as
a
crucial
regulatory
process,
instrumental
in
the
removal
of
senescent,
dysfunctional,
and
damaged
cells.
Within
autophagic
lysosomal
digestion
plays
critical
role
elimination
impaired
organelles,
thus
preserving
fundamental
cellular
metabolic
functions
various
biological
processes.
Mitophagy,
targeted
process
that
specifically
focuses
on
mitochondria,
essential
for
sustaining
health
energy
balance.
Therefore,
deep
comprehension
operational
mechanisms
implications
autophagy
mitophagy
vital
disease
prevention
treatment.
In
this
context,
we
examine
during
hair
follicle
cycles,
closely
scrutinizing
their
potential
association
with
loss.
We
also
conduct
thorough
review
behind
mitophagy,
highlighting
interaction
stem
cells
dermal
papilla
conclusion,
investigate
manipulating
pathways
to
develop
innovative
therapeutic
strategies
The FASEB Journal,
Journal Year:
2024,
Volume and Issue:
38(20)
Published: Oct. 24, 2024
LC3-associated
phagocytosis
(LAP)
is
a
distinct
type
of
autophagy
that
involves
the
sequestration
extracellular
material
by
phagocytes.
Beyond
removal
dead
cells
and
cellular
debris
from
eukaryotic
cells,
LAP
also
involved
in
variety
pathogens,
including
bacteria,
fungi,
viruses.
These
events
are
integral
to
multiple
physiological
pathological
processes,
such
as
host
defense,
inflammation,
tissue
homeostasis.
Dysregulation
has
been
associated
with
pathogenesis
several
human
diseases,
infectious
autoimmune
neurodegenerative
diseases.
Thus,
understanding
molecular
mechanisms
underlying
its
involvement
diseases
may
provide
new
insights
into
development
novel
therapeutic
strategies
for
these
conditions.
In
this
review,
we
summarize
highlight
current
consensus
on
role
biological
functions
disease
progression
propose
strategies.
Further
studies
needed
illustrate
precise
determine
targets
LAP-associated
pathologies.
