Emerging nitric oxide gas‐assisted cancer photothermal treatment

Exploration, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 24, 2024

Abstract Photothermal therapy (PTT) has garnered significant attention in recent years, but the standalone application of PTT still faces limitations that hinder its ability to achieve optimal therapeutic outcomes. Nitric oxide (NO), being one most extensively studied gaseous molecules, presents itself as a promising complementary candidate for PTT. In response, various nanosystems have been developed enable simultaneous utilization and NO‐mediated gas (GT), with integration photothermal agents (PTAs) thermally‐sensitive NO donors prevailing approach. This combination seeks leverage synergistic effects GT while mitigating potential risks associated toxicity through use single laser irradiation. Furthermore, additional internal or external stimuli employed trigger release when combined different types PTAs, thereby further enhancing efficacy. comprehensive review aims summarize advancements gas‐assisted cancer treatment. It commences by providing an overview precursors, including those sensitive photothermal, light, ultrasound, reactive oxygen species, glutathione. These precursors are discussed context dual‐modal PTT/GT. Subsequently, incorporation other treatment modalities such chemotherapy (CHT), photodynamic (PDT), alkyl radical therapy, radiation immunotherapy (IT) creation triple‐modal nanoplatforms is presented. The explores tetra‐modal therapies, PTT/GT/CHT/PDT, PTT/GT/CHT/chemodynamic (CDT), PTT/GT/PDT/IT, PTT/GT/starvation (ST)/IT, PTT/GT/Ca 2+ overload/IT, PTT/GT/ferroptosis (FT)/IT, PTT/GT/CDT/IT. Finally, challenges future perspectives concerning these novel paradigms discussed. anticipated serve valuable resource studies focused on development innovative photothermal/NO‐based nanotheranostics.

Language: Английский

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Gas Therapy: Generating, Delivery, and Biomedical Applications

Small Methods, Journal Year: 2024, Volume and Issue: 8(8)

Published: Jan. 9, 2024

Abstract Oxygen (O 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and ) with direct effects, dioxide (CO complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery in situ generation these gases controllable release at site disease has attracted attention to avoid risk gas poisoning improve their performance treating such cancer therapy, cardiovascular bone tissue engineering, wound healing. Stimuli‐responsive gas‐generating sources systems based biomaterials that enable on‐demand promising approaches for precise therapy. This work highlights current advances design development new generate deliver behavior. delivered biomedical applications is then discussed.

Language: Английский

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Pollutants in aquatic system: a frontier perspective of emerging threat and strategies to solve the crisis for safe drinking water

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(53), P. 113242 - 113279

Published: Oct. 21, 2023

Language: Английский

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Ultrasound targeted microbubble destruction-triggered nitric oxide release via nanoscale ultrasound contrast agent for sensitizing chemoimmunotherapy

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Jan. 30, 2023

Immunotherapy had demonstrated inspiring effects in tumor treatment, but only a minority of people could benefit owing to the hypoxic and immune-suppressed microenvironment (TME). Therefore, there was an urgent need for strategy that relieve hypoxia increase infiltration lymphocytes simultaneously. In this study, novel acidity-responsive nanoscale ultrasound contrast agent (L-Arg@PTX nanodroplets) constructed co-deliver paclitaxel (PTX) L-arginine (L-Arg) using homogenization/emulsification method. The L-Arg@PTX nanodroplets with uniform size about 300 nm high drug loading efficiency displayed good diagnostic imaging capability, improved aggregation achieved ultrasound-triggered release, which prevent premature leakage drugs thus improve biosafety. More critically, combination targeted microbubble destruction (UTMD) cellular reactive oxygen species (ROS), exerted oxidizing effect converted L-Arg into nitric oxide (NO), alleviating hypoxia, sensitizing chemotherapy increasing CD8 + cytotoxic T (CTLs) infiltration. Combined chemotherapeutic PTX-induced immunogenic cell death (ICD), promising enhance immunotherapy synergistically realize powerful treatment effect. Taken together, very hopeful vehicle integrated delivery, imaging, chemoimmunotherapy.

Language: Английский

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Nitric oxide-driven nanotherapeutics for cancer treatment

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 151 - 169

Published: Aug. 31, 2023

Language: Английский

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Nitric Oxide-Loaded Bioinspired Lipoprotein Normalizes Tumor Vessels To Improve Intratumor Delivery and Chemotherapy of Albumin-Bound Paclitaxel Nanoparticles

Nano Letters, Journal Year: 2023, Volume and Issue: 23(3), P. 939 - 947

Published: Jan. 26, 2023

The disorganized vasculatures in tumors represent a substantial challenge of intratumor nanomedicine delivery to exert the anticancer effects. Herein, we rationally designed glutathione (GSH)-activated nitric oxide (NO) donor loaded bioinspired lipoprotein system (NO-BLP) normalize tumor vessels and then promote efficiency sequential albumin-bound paclitaxel nanoparticles (PAN) tumors. NO-BLP exhibited higher accumulation deeper penetration versus counterpart liposomal formulation (NO-Lipo) 4T1 breast cancer tumors, thus producing notable vascular normalization efficacy causing 2.33-fold increase PAN accumulation. strategy plus resulted an 81.03% inhibition growth which was better than monotherapy, NO-Lipo treatment. Therefore, provides encouraging platform nanomedicines for effective

Language: Английский

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The Effectiveness of L-arginine in Clinical Conditions Associated with Hypoxia

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(9), P. 8205 - 8205

Published: May 3, 2023

The review summarises the data of last 50 years on effectiveness amino acid L-arginine in therapeutic practice conditions accompanied by different-origin hypoxia. aim this was to analyse literature and our research role nitric oxide modulation individual physiological reactivity considers possibility eliminating methodological conflicts case L-arginine, which can be solved taking into account (or hypoxia resistance factor). Considerable attention is paid genetic epigenetic mechanisms adaptation different models. article presents clinical cardiovascular system diseases (hypertension, atherosclerosis, coronary heart disease, etc.) stress disorders associated with these diseases. a generalised analysis techniques, use athletes, ambiguous NO physiology pathology hypoxic states shown via synthesis. Data protective effects formation high sportsmen are demonstrated. demonstrates favourable effect supplementation its application depending mitochondrial oxidative phosphorylation processes biochemical indices groups individuals low capacity In initial anti-hypoxic reserves, achieved blockade NO-dependent biosynthesis pathways. Therefore, tasks experiments consequences treatment should include component basic level reactivity.

Language: Английский

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A Cascade-Amplified Pyroptosis Inducer: Optimizing Oxidative Stress Microenvironment by Self-Supplying Reactive Nitrogen Species Enables Potent Cancer Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 16967 - 16981

Published: June 18, 2024

Selective generation of sufficient pyroptosis inducers at the tumor site without external stimulation holds immense significance for a longer duration immunotherapy. Here, we report cascade-amplified inducer CSCCPT/SNAP that utilizes reactive nitrogen species (RNS), self-supplied from diffusion-controlled reaction between oxygen (ROS) and nitric oxide (NO) to potentiate immunotherapy, while both endogenous mitochondrial ROS stimulated by released camptothecin NO initiate pyroptosis. Mechanistically, cascade amplification antitumor immune response is prompted cooperation enhanced RNS with long lifetime, which could be used as trigger effectively compensate inherent drawbacks ROS, resulting in long-lasting favoring Tumor growth efficiently inhibited mouse melanoma tumors through facilitation oxygen/nitrogen (RONS)-NO synergy. In summary, our therapeutic approach supramolecular engineering nanotechnology integrate producers donors tumor-specific stimulus responses into system guarantees synchronous these two elicit pyroptosis-evoked response, using amplifier. RONS-NO synergy achieves sustained robust cancer

Language: Английский

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Steering Piezocatalytic Therapy for Optimized Tumoricidal Effect

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(33)

Published: May 16, 2024

Abstract Piezocatalysts, because of their mechano‐electrical conversion properties, are exploited for various medical applications, such as sterilization, tissue engineering, biosensing, and disease theranostics. In particular, based on the unique advantage piezoelectric effect, piezocatalytic therapy (PCT) has been developed a novel promising candidate tumor therapy. To optimize utilization piezocatalysts in therapy, comprehensive understanding antitumor mechanism associated with these materials is imperative. Here, action principle elucidated by investigating piezocatalysts, reactants, energy inputs, products. Subsequently, mechanisms PCT have extensively discussed recapitulative follows: restraining cell proliferation, inducing programmed death, hindering metastasis, inhibiting angiogenesis, enhancing immunity. Additionally, optimized therapeutic outcomes PCT‐centric synergistic cancer systematically described. Finally, main challenges future research directions piezocatalysis applied envisioned. It believed that will serve new‐generation ingenious tool treatment.

Language: Английский

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Tumor‐Specific Nano‐Herb Delivery System with High L‐Arginine Loading for Synergistic Chemo and Gas Therapy against Cervical Cancer

Small, Journal Year: 2024, Volume and Issue: 20(45)

Published: Aug. 5, 2024

Abstract Cancer metastasis poses significant challenges in current clinical therapy. Osthole (OST) has demonstrated efficacy treating cervical cancer and inhibiting metastasis. Despite these positive results, its limited solubility, poor oral absorption, low bioavailability, photosensitivity hinder application. To address this limitation, a glutathione (GSH)‐responded nano‐herb delivery system (HA/MOS@OST&L‐Arg nanoparticles, HMOA NPs) is devised for the targeted of OST with cascade‐activatable nitric oxide (NO) release. The NPs engineered utilizing enhanced permeability retention (EPR) effects active targeting mediated by hyaluronic acid (HA) binding to glycoprotein CD44. cargoes, including L‐Arginine (L‐Arg), are released rapidly due degradation GSH‐responsive mesoporous organic silica (MOS). Then abundant reactive oxygen species (ROS) produced from presence high concentrations NAD(P)H quinone oxidoreductase 1 (NQO1), resulting generation NO subsequently highly toxic peroxynitrite (ONOO − ) catalyzing guanidine groups L‐Arg. These ROS, NO, ONOO molecules have direct impact on mitochondrial function reducing membrane potential adenosine triphosphate (ATP) production, thereby promoting increased apoptosis Overall, results indicated that great as promising alternative treatment cancer.

Language: Английский

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