Journal of Pineal Research,
Journal Year:
2024,
Volume and Issue:
76(5)
Published: July 8, 2024
ABSTRACT
Colistin
is
renowned
as
a
last‐resort
antibiotic
due
to
the
emergence
of
multidrug‐resistant
pathogens.
However,
its
potential
toxicity
significantly
hampers
clinical
utilization.
Melatonin,
chemically
known
N
‐acetyl‐5‐hydroxytryptamine,
an
endogenous
hormone
produced
by
pineal
gland
and
possesses
diverse
biological
functions.
protective
role
melatonin
in
alleviating
antibiotic‐induced
intestinal
inflammation
remains
unknown.
Herein,
we
reveal
that
colistin
stimulation
markedly
elevates
inflammatory
levels
compromises
gut
barrier.
In
contrast,
pretreatment
with
safeguards
mice
against
mucosal
damage.
Microbial
diversity
analysis
indicates
supplementation
prevents
reduction
abundance
Erysipelotrichales
Bifidobacteriales
,
well
increase
Desulfovibrionales
abundance,
following
exposure.
Remarkably,
short‐chain
fatty
acids
(SCFAs)
shows
propanoic
acid
contributes
effect
on
colistin‐induced
inflammation.
Furthermore,
protection
effects
LPS‐induced
cellular
RAW
264.7
cells
are
confirmed.
Mechanistic
investigations
suggest
intervention
can
repress
activation
TLR4
signal
downstream
NF‐κB
MAPK
signaling
pathways,
thereby
mitigating
toxic
colistin.
Our
work
highlights
unappreciated
preventing
detrimental
health
suggests
combined
therapeutic
strategy
effectively
manage
infectious
diseases.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(20)
Published: March 27, 2023
Abstract
Nanotechnology
shows
the
power
to
improve
efficacy
and
reduce
adverse
effects
of
anticancer
agents.
As
a
quinone‐containing
compound,
beta‐lapachone
(LAP)
is
widely
employed
for
targeted
therapy
under
hypoxia.
The
principal
mechanism
LAP‐mediated
cytotoxicity
believed
due
continuous
generation
reactive
oxygen
species
with
aid
NAD(P)H:
quinone
oxidoreductase
1
(NQO1).
cancer
selectivity
LAP
relies
on
difference
between
NQO1
expression
in
tumors
that
healthy
organs.
Despite
this,
clinical
translation
faces
problem
narrow
therapeutic
window
challenging
dose
regimen
design.
Herein,
multifaceted
briefly
introduced,
advance
nanocarriers
delivery
reviewed,
combinational
approaches
enhance
potency
recent
years
are
summarized.
mechanisms
by
which
nanosystems
boost
efficacy,
including
tumor
targeting,
cellular
uptake
enhancement,
controlled
cargo
release,
enhanced
Fenton
or
Fenton‐like
reaction,
multidrug
synergism,
also
presented.
problems
nanomedicines
prospective
solutions
discussed.
current
review
may
help
unlock
potential
cancer‐specific
speed
up
its
translation.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(13)
Published: Dec. 21, 2023
Abstract
Almost
all
cancer
treatments
are
significantly
limited
by
the
strong
tumor
microenvironment
(TME)
fortress
formed
abnormal
vasculature,
dense
extracellular
matrix
(ECM),
multidrug
resistance
(MDR)
system,
and
immune
“cold”
environment.
In
huge
efforts
of
dismantling
TME
fortress,
nitric
oxide
(NO)‐based
nanomedicines
increasingly
occupying
a
central
position
have
already
been
identified
as
super
“strong
polygonal
warriors”
to
dismantle
for
efficient
treatment,
benefiting
from
NO's
unique
physicochemical
properties
extremely
fascinating
biological
effects.
However,
there
is
paucity
systematic
review
elaborate
on
progress
fundamental
mechanism
NO‐based
in
oncology
this
aspect.
Herein,
key
characteristics
potential
NO
reprogramming
delineated
highlighted.
The
evolution
donors
advantages
discussed
subsequently.
Moreover,
latest
solid
tumors
comprehensively
reviewed,
including
normalizing
overcoming
ECM
barrier,
reversing
MDR,
reactivating
immunosuppression
TME.
Lastly,
prospects,
limitations,
future
directions
manipulation
provide
new
insights
into
construction
more
applicable
anticancer
nanomedicines.
ACS Applied Nano Materials,
Journal Year:
2023,
Volume and Issue:
7(16), P. 18590 - 18609
Published: Oct. 20, 2023
The
free
radical
nitric
oxide
(NO)
is
a
signaling
molecule
that
controls
several
important
physiological
and
pathophysiological
processes
in
mammals
plants.
In
humans,
the
biological
impacts
of
NO
include,
but
are
not
limited
to,
key
roles
cardiovascular,
neurological,
immunological,
respiratory,
reproductive
systems.
plants,
modulates
plant
growth
development
with
defense
against
biotic
abiotic
stress
conditions.
However,
administration
exogenous
donors
still
faces
limitations,
mainly
due
to
their
instability
lack
bioavailability
system.
Recently,
combination
nanomaterials
has
been
extensively
explored
as
promising
strategy
tailor
spatiotemporal
release
therapeutic
amounts
NO.
Nanoscience
offers
smart
approaches
deliver
on
demand
for
particular
application.
Although
this
shown
results,
scientific
studies
less
agricultural
applications
compared
biomedical
research.
current
review
summarizes
impact
research
emphasizes
recent
progress
nanotechnology
donors.
advantages,
challenges,
drawbacks
discussed
light
inspiring
exciting
topic,
aiming
translate
these
innovations
into
clinical/practical
settings.
Medical Gas Research,
Journal Year:
2025,
Volume and Issue:
15(2), P. 309 - 317
Published: Jan. 18, 2025
Medical
gases
were
primarily
used
for
respiratory
therapy
and
anesthesia,
which
showed
promising
potential
in
the
cancer
therapy.
Several
physiological
pathological
processes
affected
by
key
gases,
such
as
oxygen,
carbon
dioxide,
nitric
oxide,
hydrogen
sulfide,
monoxide.
Oxygen
targets
shrinking
tumor
via
hyperbaric
oxygen
therapy,
once
combined
with
radiation
it
enhances
its
effect.
Nitric
oxide
has
both
anti-
pro-tumor
effects
depending
on
level;
at
high
doses,
triggers
cell
death
while
low
doses
supports
growth.
The
same
concept
is
applied
to
sulfide
promotes
growth
enhancing
mitochondrial
bioenergetics
supporting
angiogenesis
concentrations,
concentrations
induces
sparing
normal
cells.
Furthermore,
dioxide
helps
induce
apoptosis
improve
oxygenation
treatments
increasing
release
of
from
hemoglobin.
Moreover,
high-dose
monoxide
gas
demonstrated
significant
reductions
vivo
supported
nanomedicine
specialized
medicines
boost
delivery
cells
availability
peroxide.
Despite
potentials
these
several
challenges
remain.
Gas
should
be
regulated
balance
anti-tumor
sulfide.
effective
systems,
nanoparticles,
developed
targeted
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 27, 2025
Scutellarin
(SC),
a
natural
flavonoid,
has
been
expansively
employed
in
treating
innumerable
inflammation-related
diseases
due
to
its
antitumor,
antiinflammatory,
anticancer,
and
antioxidant
potential.
can
inhibit
significant
inflammatory
cell
signaling
pathways,
comprisingPI3K/Akt,
NF-κB,
MAPK,
while
activating
antioxidant-related
pathways
such
as
Nrf2
ARE.
Numerous
reviews
have
outlined
scutellarin’s
pharmacological
effects
associated
mechanisms
diseases.
Several
studies
elucidated
the
of
anticancer
activity
by
inhibiting
various
pathways;
however,
our
knowledge,
none
distinguished
potential
scutellarin
based
on
different
human
cancer
types.
Our
review
detailed
insights
about
type
body.
Furthermore,
we
also
formulations,
combinatorial
therapies,
comprehensive
mechanistic
research
deliver
enhanced
effective
treatment
options
for
patients.
This
study
will
provide
thorough
into
scutellarin,
supporting
development
promising
candidate
treatment.
Clinical Cosmetic and Investigational Dermatology,
Journal Year:
2024,
Volume and Issue:
Volume 17, P. 1701 - 1710
Published: July 1, 2024
Alopecia
significantly
affects
the
appearance
and
psychology
of
patients,
pharmacological
therapies
hair
transplantation
are
main
treatments
for
alopecia,
but
both
have
limitations.
This
review
aimed
to
summarize
non-pharmacological
that
promote
growth
regeneration.
