Artificial
Intelligence
(AI)
is
a
breakthrough technology
that
has
been
widely
applied
in
many
fields
and
its
use
pharmacy
also
gaining
increasing
attentions.
Recently,
ChatGPT,
newly
developed
virtual
assistant
large
language
model,
showing
strong
ability
writing,
which
makes
it
potential
tool
for
review
writing.
Here
our
study,
we
employ
the
public
available
ChatGPT
try
to
instruct
generate
mini
on
topic
of
“lipid-based
drug
delivery
systems”
by
conversation.
Our
results
showed
can
give
reasonable
outline
this
seemingly
sentences
with
concluding
wording,
useful
information
readers.
However,
accuracy
consistence
are
not
fully
guaranteed
there
lack
reliable
citations.
Therefore,
concluded
only
general
knowledge
selected
topic,
but
capable
giving
in-depth
discussion.
The
generated
article
be
occasionally
unprecise
electronic
encyclopedia
instead
rigorous
scientific
literature,
benefit
pharmaceutical
education
interchange
some
extent.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(3), P. 772 - 772
Published: Feb. 26, 2023
Numerous
drugs
have
emerged
to
treat
various
diseases,
such
as
COVID-19,
cancer,
and
protect
human
health.
Approximately
40%
of
them
are
lipophilic
used
for
treating
diseases
through
delivery
routes,
including
skin
absorption,
oral
administration,
injection.
However,
a
low
solubility
in
the
body,
drug
systems
(DDSs)
being
actively
developed
increase
bioavailability.
Liposomes,
micro-sponges,
polymer-based
nanoparticles
been
proposed
DDS
carriers
drugs.
their
instability,
cytotoxicity,
lack
targeting
ability
limit
commercialization.
Lipid
(LNPs)
fewer
side
effects,
excellent
biocompatibility,
high
physical
stability.
LNPs
considered
efficient
vehicles
owing
lipid-based
internal
structure.
In
addition,
recent
LNP
studies
suggest
that
bioavailability
can
be
increased
surface
modifications,
PEGylation,
chitosan,
surfactant
protein
coating.
Thus,
combinations
an
abundant
utilization
potential
fields
DDSs
carrying
this
review,
functions
efficiencies
types
modifications
optimize
discussed.
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(2), P. 186 - 186
Published: Feb. 12, 2024
In
recent
years,
lipid
nanoparticles
(LNPs)
have
attracted
extensive
attention
in
tumor
immunotherapy.
Targeting
immune
cells
cancer
therapy
has
become
a
strategy
of
great
research
interest.
mRNA
vaccines
are
potential
choice
for
immunotherapy,
due
to
their
ability
directly
encode
antigen
proteins
and
stimulate
strong
response.
However,
the
mode
delivery
lack
stability
key
issues
limiting
its
application.
LNPs
an
excellent
carrier,
structural
biocompatibility
make
them
effective
means
delivering
specific
targets.
This
study
summarizes
progress
LNP
carrier-assisted
targeted
controlled
release
immunity.
The
role
improving
stability,
immunogenicity,
targeting
is
discussed.
review
aims
systematically
summarize
latest
immunity
provide
new
ideas
strategies
as
well
more
treatment
plans
patients.
Bioconjugate Chemistry,
Journal Year:
2023,
Volume and Issue:
34(7), P. 1177 - 1197
Published: July 11, 2023
Short
interfering
RNAs
(siRNA)
are
a
powerful
class
of
genetic
medicines
whose
clinical
translation
can
be
hindered
by
their
suboptimal
delivery
properties
in
vivo.
Here,
we
provide
clinically
focused
overview
that
summarizes
ongoing
siRNA
trials
from
the
perspective
innovations
nonviral
strategies.
More
specifically,
our
review
begins
highlighting
barriers
and
physiochemical
make
it
challenging
to
deliver
We
then
commentary
on
specific
strategies,
including
sequence
modification,
ligand
conjugation,
nanoparticle
exosomal
packaging,
each
which
used
control
therapies
living
systems.
Last,
summary
table
also
highlights
indication
use,
target,
National
Clinical
Trial
(NCT)
number
associated
with
entry.
In
writing
this
review,
work
aims
highlight
key
challenges
strategies
for
effective
vivo,
while
simultaneously
summarizing
information
therapy
humans.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 15, 2024
Abstract
Nanotechnology
holds
immense
promise
in
revolutionising
healthcare,
offering
unprecedented
opportunities
diagnostics,
drug
delivery,
cancer
therapy,
and
combating
infectious
diseases.
This
review
explores
the
multifaceted
landscape
of
nanotechnology
healthcare
while
addressing
critical
aspects
safety
environmental
risks
associated
with
its
widespread
application.
Beginning
an
introduction
to
integration
we
first
delved
into
categorisation
various
materials
employed,
setting
stage
for
a
comprehensive
understanding
potential.
We
then
proceeded
elucidate
diverse
applications
nanotechnology,
spanning
medical
tissue
engineering,
targeted
gene
development
antimicrobial
agents.
The
discussion
extended
current
situation
surrounding
clinical
translation
commercialisation
these
cutting-edge
technologies,
focusing
on
nanotechnology-based
products
that
have
been
approved
globally
date.
also
discussed
considerations
nanomaterials,
both
terms
human
health
impact.
presented
vivo
nanomaterial
exposure,
relation
transport
mechanisms,
oxidative
stress,
physical
interactions.
Moreover,
highlighted
risks,
acknowledging
potential
implications
ecosystems
biodiversity.
Lastly,
strived
offer
insights
regulatory
governing
across
different
regions
globally.
By
synthesising
perspectives,
underscore
imperative
balancing
innovation
stewardship,
charting
path
forward
responsible
healthcare.
Graphical
abstract
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(6), P. 3013 - 3036
Published: Feb. 26, 2024
The
immune
system's
complexity
and
ongoing
evolutionary
struggle
against
deleterious
pathogens
underscore
the
value
of
vaccination
technologies,
which
have
been
bolstering
human
immunity
for
over
two
centuries.
Despite
noteworthy
advancements
these
200
years,
three
areas
remain
recalcitrant
to
improvement
owing
environmental
instability
biomolecules
used
in
vaccines─the
challenges
formulating
them
into
controlled
release
systems,
their
need
constant
refrigeration
avoid
loss
efficacy,
requirement
that
they
be
delivered
via
needle
gastrointestinal
incompatibility.
Nanotechnology,
particularly
metal–organic
frameworks
(MOFs)
covalent
organic
(COFs),
has
emerged
as
a
promising
avenue
confronting
challenges,
presenting
new
frontier
vaccine
development.
Although
materials
widely
explored
context
drug
delivery,
imaging,
cancer
immunotherapy,
role
immunology
vaccine-related
applications
is
recent
yet
rapidly
developing
field.
This
review
seeks
elucidate
prospective
use
MOFs
COFs
biomaterial
stabilization,
eliminating
necessity
cold
chains,
enhancing
antigen
potency
adjuvants,
potentializing
needle-free
delivery
vaccines.
It
provides
an
expansive
critical
viewpoint
on
this
evolving
field
research
emphasizes
vital
contribution
chemists
driving
further
advancements.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(13), P. 7333 - 7333
Published: July 4, 2024
Clustered
regularly
interspersed
short
palindromic
repeats
(CRISPR)/CRISPR-associated
protein
9
(Cas9)
technology
has
revolutionized
the
field
of
gene
therapy
as
it
enabled
precise
genome
editing
with
unprecedented
accuracy
and
efficiency,
paving
way
for
clinical
applications
to
treat
otherwise
incurable
genetic
disorders.
Typically,
requires
delivery
multiple
components
target
cells
that,
depending
on
platform
used,
may
include
messenger
RNA
(mRNA),
complexes,
DNA
fragments.
For
purposes,
these
have
be
efficiently
delivered
into
transplantable
cells,
such
primary
T
lymphocytes
or
hematopoietic
stem
progenitor
that
are
typically
sensitive
exogenous
substances.
This
challenge
limited
broad
applicability
those
strategies
which
efficient
methods
available.
Electroporation-based
methodologies
been
generally
applied
applications,
but
procedure-associated
toxicity
represented
a
major
burden.
With
advent
novel
less
disruptive
deliver
cargo
is
now
possible
safely
editing,
thus
expanding
strategies.
In
this
review,
we
describe
different
systems
available
components,
including
viral
non-viral
systems,
highlighting
their
advantages,
limitations,
recent
applications.
Recent
improvements
achieve
cell
specificity
represent
critical
development
enable
in
vivo
targeting
future
will
certainly
play
pivotal
role
field.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: April 15, 2024
Abstract
Over
the
last
two
decades,
lipid
nanoparticles
(LNPs)
have
evolved
as
an
effective
biocompatible
and
biodegradable
RNA
delivery
platform
in
fields
of
nanomedicine,
biotechnology,
drug
delivery.
They
are
novel
bionanomaterials
that
can
be
used
to
encapsulate
a
wide
range
biomolecules,
such
mRNA,
demonstrated
by
current
successes
COVID‐19
mRNA
vaccines.
Therefore,
it
is
important
provide
perspective
on
LNPs
for
delivery,
which
further
offers
useful
guidance
researchers
who
want
work
RNA‐based
LNP
field.
This
first
summarizes
approaches
preparation
LNPs,
followed
introduction
key
characterization
parameters.
Then,
vitro
cell
experiments
study
performance,
including
selection,
viability,
cellular
association/uptake,
endosomal
escape,
their
efficacy,
were
summarized.
Finally,
vivo
animal
aspects
administration,
dosing
safety,
therapeutic
efficacy
discussed.
The
authors
hope
this
offer
valuable
enter
field
help
them
understand
crucial
parameters
demand.
