Journal of Physical Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
37(7)
Published: Dec. 20, 2023
Abstract
Three
new
copper(II)
mononuclear
complexes
containing
different
organoselenium
groups
(
1
–
3
)
were
synthesized
and
characterized
by
the
following
techniques:
elemental
analysis,
IR
UV‐Vis
spectroscopies,
electrochemical
conductimetric
mass
spectrometry.
complexes,
with
substituents
made
in
para
position
of
aromatic
portion
N
,
‐bis(2‐(phenylselanyl)ethyl)amine
ligand:
p
‐OCH
),
‐CH
2
‐Cl
synthetized
to
compare
already
published
complex
4
no
substituents.
The
ligand
coordinates
center
a
tridentate
way
Se
as
donor
atoms.
hydrolytic
activity
phosphate
diester
cleavage
was
investigated
using
2,4‐BDNPP
substrate.
modifications
are
reflected
difference
between
catalytic
activation
parameters,
where
k
cat
values
follow
order:
>
.
Dalton Transactions,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Systematic
structural
variation
in
a
series
of
lytic
polysaccharide
monooxygenase
active
site
mimics
strongly
influences
their
electrochemical
and
oxidative
reactivity.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(12), P. 9479 - 9509
Published: Jan. 1, 2025
Elaborated
molecular
architectures,
specifically
those
containing
a
2-aminophenoxazinone
scaffold,
belong
to
one
of
the
most
ubiquitous
and
prominent
classes
heterocyclic
frameworks,
going
from
natural
products
biologically
active
pharmaceutical
molecules
agrochemicals
functional
materials
polymers.
Therefore,
efficient
synthetic
strategies
for
assembly
frameworks
are
always
in
demand
have
gained
attention
academic
industrial
communities.
Methodologies
that
involve
cascade
reactions
generally
catalyzed
by
transition
metal
complexes,
such
as
iron,
cobalt,
manganese,
copper,
zinc
stood
out
representative
approach.
Over
past
few
decades,
great
deal
versatile,
atom-economic,
straightforward
protocols
been
reported
generation
value-added
sustainable,
powerful,
applicable
manner.
The
state-of-the-art
methodologies
toward
construction
skeletons
summarized
this
review,
which
could
be
divided
into
four
categories:
(1)
compounds
complexes;
(2)
biosynthetic
enzymes;
(3)
process
routes
compounds;
(4)
via
other
innovative
methods.
Physical review. A/Physical review, A,
Journal Year:
2024,
Volume and Issue:
109(2)
Published: Feb. 28, 2024
Vibronic
coupling
plays
a
crucial
role
in
x-ray
photoelectron
spectra
(XPS)
of
molecules.
In
series
three
papers,
we
present
comprehensive
exploration
the
$N$-heterocycles
family,
known
for
their
diverse
structures,
to
summarize
general
rules
vibronic
high-resolution
vibrationally
resolved
XPS
at
N
$1s$
edge.
Building
upon
our
previous
studies
on
six-membered
monocyclic
azines
[Phys.
Rev.
A
106,
022811
(2022)]
and
fused
bicyclic
compounds
indoles
with
five
six
members
108,
022816
(2023)],
this
study,
focus
investigating
12
five-membered
using
Franck-Condon
simulations,
incorporating
Duschinsky
rotation
effects
density
functional
theory.
Our
calculations
reveal
distinct
spectral
characteristics
amine
imine
within
these
systems
binding
energies,
characteristics,
structural
changes,
vibrational
strengths,
hydrogenation.
Furthermore,
expand
analysis
encompass
all
35
discussed
papers
consolidate
findings
into
rules.
We
find
that
ionization
nitrogen
induces
more
substantial
geometrical
resulting
larger
strength
compared
nitrogens.
The
nitrogens
exhibit
two
characteristic
peaks
originating
from
0-0
0-1
transitions,
whereas
are
characterized
by
broad
peak
numerous
weak
fingerprints
due
significant
mixing
various
0-$n$
transitions.
observe
(imine)
generally
cause
negative
(positive)
change
zero-point
energy.
This
study
provides
valuable
insights
$N$-heterocycles,
shedding
light
distinguishing
features
behavior
spectra.
Dalton Transactions,
Journal Year:
2024,
Volume and Issue:
53(34), P. 14364 - 14377
Published: Jan. 1, 2024
Copper(
ii
)
complexes
of
NN
2
-pincer
type
ligands
are
effective
against
lung
cancer
cells
and
their
mechanism
action
is
found
to
be
apoptosis
induced
by
ROS.
Inorganic Chemistry,
Journal Year:
2023,
Volume and Issue:
62(46), P. 18926 - 18939
Published: Nov. 6, 2023
WHO
lists
AMR
as
one
of
the
top
ten
global
public
health
issues.
Therefore,
constant
effort
is
needed
to
develop
more
efficient
antimicrobial
drugs.
As
a
result,
earth-abundant
transition-metal
complexes
have
emerged
an
excellent
solution.
In
this
regard,
new
aminoquinoline-based
copper(II)
pincer
1-3
were
designed,
synthesized,
and
characterized
by
modern
spectroscopic
techniques.
It
worth
mentioning
that,
at
highest
concentration
(1024
μg/mL)
(1-3),
hemolysis
was
found
be
<15%,
implying
their
less
toxicity.
Further,
effectively
interfered
with
growth
Gram
positive
MRSA
fungus
Candida
albicans.
Among
them,
complex
2
promising
(MIC
=
16
against
MRSA,
which
better
than
known
antibacterial
drug
kanamycin
(64
under
identical
conditions.
The
Alamar
blue
cell
viability
test
MBC/MFC
identified
spot
assay
in
accordance
MIC
values.
Moreover,
insilico
studies
explained
most
probable
mechanism
action
inhibition
wall
biosynthesis
dysfunction
antibiotic
sensing
proteins.
Similarly,
antifungal
might
due
surface
adhesion
protein
complexes.
Furthermore,
we
are
expecting
draw
these
compounds
for
clinical
applications.
A
series
of
small
molecule
Cu(II)
complexes
based
on
tridentate
N3
ligands
relevant
to
the
histidine
brace
active
site
lytic
polysaccharide
monooxygenase
were
synthesized
and
characterized
by
X-ray
crystallography
spectroscopic
studies.
In
order
better
understand
role
different
structural
features
help
bridge
differences
between
previously
reported
models,
methylation
patterns,
imidazole
connectivity,
linker
nature,
type
heterocycle
systematically
varied
across
series.
These
modifications
lead
important
in
electrochemical
properties
their
reactivity
towards
oxidation
a
model
substrate.
Biosensors,
Journal Year:
2024,
Volume and Issue:
14(1), P. 54 - 54
Published: Jan. 20, 2024
Introducing
3-aminotyrosine
(aY),
a
noncanonical
amino
acid
(ncAA),
into
green
fluorescent
protein
(GFP)-like
chromophores
shows
promise
for
achieving
red-shifted
fluorescence.
However,
inconsistent
results,
including
undesired
species,
hinder
the
effectiveness
of
this
approach.
In
study,
we
optimized
expression
conditions
an
aY-derived
cpGFP
(aY-cpGFP).
Key
factors
like
rich
culture
media
and
oxygen
restriction
pre-
post-induction
enabled
high-yield,
high-purity
production
protein.
We
also
engineered
two
variants
aY-cpGFP
with
enhanced
brightness
by
mutating
few
residues
surrounding
chromophore.
further
investigated
sensitivity
to
metal
ions,
reactive
species
(ROS),
nitrogen
(RNS).
Incorporating
aY
had
minimal
impact
on
ion
reactivity
but
increased
response
RNS.
Expanding
these
findings,
examined
in
mammalian
cells
found
that
reductants
significantly
red-emitting
product.
Our
study
indicates
optimizing
promote
reduced
cellular
state
proved
effective
producing
desired
product
both
