Delta variant (B.1.617.2) of SARS-CoV-2: Mutations, impact, challenges and possible solutions

Human Vaccines & Immunotherapeutics, Journal Year: 2022, Volume and Issue: 18(5)

Published: May 4, 2022

Since commencement of COVID-19 pandemic, several SARS-CoV-2 variants have emerged amid containment efforts via vaccination. The Delta variant (B.1.617.2), discovered in October 2020, was designated as a VOC by the WHO on May 11, 2021. enhanced transmissibility has been associated with critical mutations such D614G, L452R, P681R, and T478K S-protein. increased affinity S-protein ACE2 postulated key reason for decreased vaccine efficacy. As per evidence, possesses efficacy compared to other VOCs like Alpha Beta. This led concerns regarding acquisition novel outbreaks vulnerable communities, including vaccinated people. In this mini-review variant, we explained its evolution characteristics, impact spike infectivity immune evasion, measures combat future outbreaks.

Language: Английский

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Acceptance and willingness to pay for COVID‐19 vaccines among pregnant women in Vietnam

Tropical Medicine & International Health, Journal Year: 2021, Volume and Issue: 26(10), P. 1303 - 1313

Published: Aug. 9, 2021

The aim of this study was to assess acceptance COVID-19 vaccination and the willingness pay (WTP) for it, investigate associated factors among pregnant women in Vietnam.

Language: Английский

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Viral infections in pregnancy and impact on offspring neurodevelopment: mechanisms and lessons learned

Pediatric Research, Journal Year: 2024, Volume and Issue: 96(1), P. 64 - 72

Published: March 20, 2024

Language: Английский

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Egypt's COVID-19 Recent Happenings and Perspectives: A Mini-Review

Frontiers in Public Health, Journal Year: 2021, Volume and Issue: 9

Published: Aug. 16, 2021

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has affected countries across the world. While zoonotic aspects of SARS-CoV-2 are still under investigation, bats and pangolins currently cited as animal origin virus. Several types vaccines against COVID-19 have been developed being used in vaccination drives A number experiencing second third waves which claimed nearly four million lives out 180 people infected globally June 2021. emerging variants mutants posing high public health concerns owing to their rapid transmissibility, higher severity, some cases, ability infect vaccinated (vaccine breakthrough). Here this mini-review, we specifically looked at efforts actions Egyptian government slow down control spread COVID-19. We also review statistics Egypt possible reasons behind low prevalence case fatality rate (CFR%), comparing with China (the epicenter pandemic) USA, Brazil, India, Italy, France first numbers patients COVID-19). Additionally, summarized variants, Egypt, use medicinal plants preventive curative options.

Language: Английский

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Natural Bioactive Molecules: An Alternative Approach to the Treatment and Control of COVID-19

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(23), P. 12638 - 12638

Published: Nov. 23, 2021

Several coronaviruses (CoVs) have been associated with serious health hazards in recent decades, resulting the deaths of thousands around globe. The coronavirus pandemic has emphasized importance discovering novel and effective antiviral medicines as quickly possible to prevent more loss human lives. Positive-sense RNA viruses group spikes protruding from their surfaces an abnormally large genome enclose CoVs. CoVs already related a range respiratory infectious diseases possibly fatal humans, such MERS, SARS, current COVID-19 outbreak. As result, prevention, treatment, medications against (HCoV) is urgently needed. In years, many natural substances discovered variety biological significance, including properties. Throughout this work, we reviewed wide that interrupt life cycles for MERS well potential application treatment COVID-19.

Language: Английский

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Maternal and neonatal immune response to SARS-CoV-2, IgG transplacental transfer and cytokine profile

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 27, 2022

SARS-CoV-2 infected pregnant women are at increased risk of severe COVID-19 than non-pregnant and have a higher adverse pregnancy outcomes like intrauterine/fetal distress preterm birth. However, little is known about the impact infection on maternal neonatal immunological profiles. In this study, we investigated inflammatory humoral responses to in cord blood paired samples. Thirty-six were recruited delivery Hospital Sant Joan de Déu, Barcelona, Spain, between April-August 2020, before having available vaccines. Maternal variables, as well perinatal outcomes, recorded questionnaires. Nasopharyngeal swabs samples collected for detection by rRT-PCR serology, respectively. We measured IgM, IgG IgA levels 6 antigens (spike [S], S1, S2, receptor-binding domain [RBD], nucleocapsid [N] full-length C-terminus), N from 4 human coronaviruses (OC43, HKU1, 229E NL63), concentrations 30 cytokines, chemokines growth factors Luminex. Mothers classified or non-infected based serology results. Sixty-four % with (positive during third trimester and/or just after delivery). None newborns tested positive rRT-PCR. mothers had virus-specific antibodies several cytokines. Those symptoms cytokine levels. IFN-α was mothers, symptomatic EGF, FGF, IL-17 IL-15 increased, whereas RANTES decreased. showed correlations their counterparts blood. lower transfer SARS-CoV-2-specific IgGs, stronger effect when closer delivery. carrying male fetus antibody IL-7 concentrations. Our results show that induces robust response causes significant reduction IgGs transplacental transfer, negative

Language: Английский

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Extracorporeal membrane oxygenation for COVID-19-related acute respiratory distress syndrome: a narrative review

Journal of Intensive Care, Journal Year: 2023, Volume and Issue: 11(1)

Published: Feb. 8, 2023

Abstract A growing body of evidence supports the use extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) refractory to maximal medical therapy. ARDS may develop in a proportion patients hospitalized coronavirus disease 2019 (COVID-19) and ECMO be used manage therapy mitigate risk ventilator-induced lung injury provide rest while awaiting recovery. The mortality COVID-19-related was variously reassessed during pandemic. Veno-venous (VV) default choice failure; however, with concomitant right ventricular dysfunction, venoarterial (VA) or mechanical assist devices gas exchange (Oxy-RVAD) were also considered. has been special populations such as pregnant women, pediatric affected by forms COVID-19, and, cases persistent seemingly irreversible failure, bridge successful transplantation. In this narrative review, we outline summarize most recent that emerged on different patient ARDS.

Language: Английский

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Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin

Current Topics in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 23(21), P. 2075 - 2096

Published: July 11, 2023

Abstract: Flavonoids effectively treat cancer, inflammatory disorders (cardiovascular and nervous systems), oxidative stress. Fisetin, derived from fruits vegetables, suppresses cancer growth by altering cell cycle parameters that lead to death angiogenesis without affecting healthy cells. Clinical trials are needed in humans prove the effectiveness of this treatment for a wide range cancers. According results study, fisetin can be used prevent variety Despite early detection advances, is leading cause worldwide. We must take proactive steps reduce risk cancer. The natural flavonoid has pharmacological properties suppress growth. This review focuses on potential drug use fisetin, which been extensively explored its cancer-fighting ability other activities such as diabetes, COVID-19, obesity, allergy, neurological, bone disorders. Researchers have focused molecular function fisetin. In review, we highlighted biological against chronic disorders, including metabolic illnesses, degenerative dietary components

Language: Английский

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The End or a New Era of Development of SARS-CoV-2 Virus: Genetic Variants Responsible for Severe COVID-19 and Clinical Efficacy of the Most Commonly Used Vaccines in Clinical Practice

Vaccines, Journal Year: 2023, Volume and Issue: 11(7), P. 1181 - 1181

Published: June 30, 2023

Although the chief of World Health Organization (WHO) has declared end coronavirus disease 2019 (COVID-19) as a global health emergency, is still threat. To be able to manage such pandemics in future, it necessary develop proper strategies and opportunities protect human life. The data on SARS-CoV-2 virus must continuously analyzed, possibilities mutation emergence new, more infectious variants anticipated, well options using different preventive therapeutic techniques. This because fast development severe acute 2 syndrome (SARS-CoV-2) concern have posed significant problem for COVID-19 pandemic control presently available vaccinations. review summarizes that are responsible clinical efficacy most commonly used vaccines practice. consequences after (long COVID or post-COVID conditions) continue subject studies research, affect social economic life worldwide.

Language: Английский

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COVID-19 vaccine and pregnancy: A safety weapon against pandemic

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 61(2), P. 201 - 209

Published: Feb. 10, 2022

The ongoing COVID-19 pandemic is raising great concern all over the world. recent introduction of vaccines has offered reason for optimism, however, new issues have arisen, such as vaccine reluctance. safety pregnant women one most serious these concerns. purpose this review article to provide updated international recommendations, results studies and clinical trials, role gynecologists in counseling understand risks versus benefits well form an informed decision towards acceptance COVID-19. Although infection increases risk severe morbidity mortality women, were not included initial trials. As a result, information scarce. Nations differing though many recently approved immunization pregnancy following risk-benefit analysis. Joint Committee on Vaccination Immunization (JCVI) United Kingdom mRNA vaccination women. recommended by CDC, ACOG, ARFM, WHO. India took stand, with ICMR Ministry Health Family Welfare recommending during lactation.

Language: Английский

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