Zonulin as a Potential Therapeutic Target in Microbiota-Gut-Brain Axis Disorders: Encouraging Results and Emerging Questions

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(8), P. 7548 - 7548

Published: April 19, 2023

The relationship between dysbiosis and central nervous diseases has been proved in the last 10 years. Microbial alterations cause increased intestinal permeability, penetration of bacterial fragment toxins induces local systemic inflammatory processes, affecting distant organs, including brain. Therefore, integrity epithelial barrier plays a role microbiota–gut–brain axis. In this review, we discuss recent findings on zonulin, an important tight junction regulator cells, which is assumed to play key maintaining blood–brain function. addition focusing effect microbiome zonulin release, also summarize potential pharmaceutical approaches modulate zonulin-associated pathways with larazotide acetate other receptor agonists or antagonists. present review addresses emerging issues, use misleading nomenclature unsolved questions about exact protein sequence zonulin.

Language: Английский

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Probiotics Supplements Improve the Sarcopenia-Related Quality of Life in Older Adults with Age-Related Muscle Decline

Calcified Tissue International, Journal Year: 2024, Volume and Issue: 114(6), P. 583 - 591

Published: April 20, 2024

Language: Английский

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Plasma zonulin levels forecast sarcopenia and physical performance in patients with knee osteoarthritis

Geriatric Nursing, Journal Year: 2025, Volume and Issue: 62, P. 115 - 122

Published: Jan. 31, 2025

Language: Английский

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Metformin Improves Sarcopenia-Related Quality of Life in Geriatric Adults: A Randomized Controlled Trial

Archives of Medical Research, Journal Year: 2024, Volume and Issue: 55(4), P. 102998 - 102998

Published: April 13, 2024

Language: Английский

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Lipid-Lowering Medications are Associated with Reduced Sarcopenia-Related Quality of Life in Older Adults with Hyperlipidemia

Drugs & Aging, Journal Year: 2024, Volume and Issue: 41(5), P. 443 - 453

Published: April 2, 2024

Language: Английский

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Butyrate supplementation reduces sarcopenia by repairing neuromuscular junction in patients with chronic obstructive pulmonary disease

Respiratory Medicine, Journal Year: 2023, Volume and Issue: 222, P. 107510 - 107510

Published: Dec. 22, 2023

Language: Английский

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Applications of Strain‐Specific Probiotics in the Management of Cardiovascular Diseases: A Systemic Review

Molecular Nutrition & Food Research, Journal Year: 2024, Volume and Issue: 68(8)

Published: March 29, 2024

Abstract Cardiovascular diseases (CVDs) are a leading cause of global mortality and novel approaches for prevention management needed. The human gastrointestinal tract hosts diverse microbiota that is crucial in maintaining metabolic homeostasis. formulation effective probiotics, alone or combination, has been under discussion due to their impact on cardiovascular diseases. Probiotics have shown health positively. An imbalance the presence Firmicutes Bacteroidetes linked progression CVDs bile acid cholesterol metabolism. probiotics primarily help reduction plasma low‐density lipoprotein levels attenuation proinflammatory markers. These beneficial microorganisms contribute lowering produce essential short‐chain fatty acids. lipid‐regulating probiotic strains quite significant. However, only few tested potential efficacy, ambiguity exists regarding strain dosages, interactions with confounding factors, adverse effects. Hence, more comprehensive studies randomized trials needed understand mechanisms ensure health. This review assesses evidence highlights roles strain‐specific CVDs.

Language: Английский

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The Association of Intestinal Leak with Sarcopenia and Physical Disability in Patients with Various Stages of Chronic Kidney Disease

Calcified Tissue International, Journal Year: 2024, Volume and Issue: 115(2), P. 132 - 141

Published: June 3, 2024

Language: Английский

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Metformin effects on plasma zonulin levels correlate with enhanced physical performance in osteoarthritis patients with diabetes

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 3195 - 3203

Published: Aug. 19, 2024

Language: Английский

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Circulating osteonectin predicts postural imbalance and cardiac dysfunction in heart failure

Vascular Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 107468 - 107468

Published: Jan. 1, 2025

Language: Английский

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