Short Communication: Taurine Long-Term Treatment Prevents the Development of Cardiac Hypertrophy, and Premature Death in Hereditary Cardiomyopathy of the Hamster Is Sex-Independent DOI Open Access
Ghassan Bkaily,

Yanick Simon,

J. Abdallah

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 946 - 946

Published: March 26, 2024

Recently, we reported that during the hypertrophic phase (230 days old) of hereditary cardiomyopathy hamster (HCMH), short-term treatment (20 days) with 250 mg/kg/day taurine prevents development hypertrophy in males but not females. However, mortality rate non-treated animals was higher females than males. To verify whether sex-dependency effect is due to difference disease’s progression, treated 230-day-old for a longer time period 122 days. Our results showed long-term low and high concentrations significantly cardiac early death HCMH (p < 0.0001 p 0.05, respectively) 0.01 0.0001, respectively). demonstrate sex dependency treatments degree heart remodeling when compared dependency. In addition, studies should consider differences between male female progression disease. Thus, therapies are recommended prevent cardiomyopathy.

Language: Английский

Advances in the Regulation of Hematopoietic Homeostasis by Programmed Cell Death Under Radiation Conditions DOI
Manling Shu, Jinfu Zhang, Haiyun Huang

et al.

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: March 8, 2025

Language: Английский

Citations

0
SGLT2 inhibitors as a novel senotherapeutic approach DOI Creative Commons
Zeynep Elif Yeşilyurt, Ce Qi,

Yi-Chian Wang

et al.

npj Aging, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 10, 2025

Abstract Cellular senescence is the permanent cessation of cell proliferation and growth. Senescent cells accumulating in tissues organs with aging contribute to many chronic diseases, mainly through secretion a pro-inflammatory senescence-associated secretory phenotype (SASP). Senotherapeutic (senolytic or senomorphic) strategies targeting senescent or/and their SASP are being developed prolong healthy lifespan treat age-related pathologies. Sodium-glucose co-transporter 2 (SGLT2) inhibitors new class anti-diabetic drugs that promote renal excretion glucose, resulting lower blood glucose levels. Beyond glucose-lowering effects, SGLT2 have demonstrated protective effects against cardiovascular events. Moreover, recently been associated inhibition senescence, making them promising therapeutic approach for aging. This review examines latest research on senotherapeutic potential inhibitors.

Language: Английский

Citations

0
Short Communication: Taurine Long-Term Treatment Prevents the Development of Cardiac Hypertrophy, and Premature Death in Hereditary Cardiomyopathy of the Hamster Is Sex-Independent DOI Open Access
Ghassan Bkaily,

Yanick Simon,

J. Abdallah

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(7), P. 946 - 946

Published: March 26, 2024

Recently, we reported that during the hypertrophic phase (230 days old) of hereditary cardiomyopathy hamster (HCMH), short-term treatment (20 days) with 250 mg/kg/day taurine prevents development hypertrophy in males but not females. However, mortality rate non-treated animals was higher females than males. To verify whether sex-dependency effect is due to difference disease’s progression, treated 230-day-old for a longer time period 122 days. Our results showed long-term low and high concentrations significantly cardiac early death HCMH (p < 0.0001 p 0.05, respectively) 0.01 0.0001, respectively). demonstrate sex dependency treatments degree heart remodeling when compared dependency. In addition, studies should consider differences between male female progression disease. Thus, therapies are recommended prevent cardiomyopathy.

Language: Английский

Citations

0