SARS-CoV-2 and Environmental Changes: The Perfect Storm DOI Creative Commons
Mario Caldarelli, Pierluigi Rio, Vincenzo Giambra

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(11), P. 11835 - 11852

Published: Oct. 23, 2024

The COVID-19 pandemic has had a significant impact on the global economy. It also provided insights into how looming climate crisis might be addressed, as there are several similarities between challenges proposed by and those expected from coming emergency. is an immediate health threat, but change represents more gradual insidious risk that will lead to long-term consequences for human health. Research shows change, air pollution pandemics have negative Recent studies show mortality increases with extremes. goal of our review analyze clinical findings they affected while providing insight emergence new variants their ability evade immune system. We selected synthesized data primary studies, reviews, meta-analyses, systematic reviews. Selection was based rigorous methodological relevance criteria. Indeed, variant SARS-CoV-2, named JN.1, emerged dominant, first in United States then worldwide; specific mutations its spike proteins increase transmissibility. According World Health Organization (WHO), JN.1 currently most reported interest (VOI), having been identified 132 countries. highlight link pandemics, emphasizing need action, targeted medical approaches scientific innovation.

Language: Английский

Microbiome Integrity Enhances the Efficacy and Safety of Anticancer Drug DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422

Published: Feb. 10, 2025

The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.

Language: Английский

Citations

3
Gut Microecological Prescription: A Novel Approach to Regulating Intestinal Micro-Ecological Balance DOI Creative Commons
Lingping Zhu, Xuefeng Yang

International Journal of General Medicine, Journal Year: 2025, Volume and Issue: Volume 18, P. 603 - 626

Published: Feb. 1, 2025

Abstract: The intestinal microecology is comprises microorganisms and other components constituting the entire ecosystem, presenting characteristics of stability dynamic balance. Current research reveals microecological imbalances are related to various diseases. However, fundamental clinical applications have not been effectively integrated. Considering importance complexity regulating balance, this study provides an overview high-risk factors affecting detection methods. Moreover, it proposes definition imbalance definition, formulation, outcomes gut prescription facilitate its application in practice, thus promoting on improving quality life population. Keywords: microecology, risk, prescription, faecal microbiota transplantation

Language: Английский

Citations

1
Adoptive transfer of natural killer cells in therapeutic treatment of COVID-19 patients DOI Creative Commons
Abdulaziz Alamri

Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 22, 2025

Abstract Background Natural killer (NK) cells are crucial constituents of innate immunity, playing a vital role in the early defense against viral infections and cancer. Their antiviral capabilities stem from direct cytotoxic activity infected immunoregulatory functions that modulate adaptive immune responses. In context Coronavirus disease (COVID-19), NK contribute to controlling replication limiting excessive inflammatory Aims This review highlights mechanisms underlying cell-mediated activity, focusing on their interactions with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). We discuss potential sources for adoptive transfer therapy, critical factors influencing therapeutic efficacy, considerations clinical translation COVID-19 treatment. Methods Various cell therapy discussed, including peripheral blood, cord genetically engineered cells. Key efficacy safety cell-based therapies analyzed, cytokine modulation, subset selection, delivery methods. Conclusion Understanding influence success can inform design more effective immunotherapies patients. Strategies improving function, such as genetic modification optimizing protocols, highlighted enhance outcomes. Graphical neutralize SARS-CoV-2 by releasing granules, inhibiting replication, modulating inflammation. They originate engineering. Therapeutic strategies include transfer, optimized delivery. Inflammation is controlled, reducing

Language: Английский

Citations

0
Microbiome dysbiosis in SARS-CoV-2 infection: implication for pathophysiology and management strategies of COVID-19 DOI Creative Commons
Shukur Wasman Smail,

Niaz Albarzinji,

Rebaz Hamza Salih

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 22, 2025

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent disease 2019 (COVID-19), in late initiated a global health crisis marked by widespread infection, significant mortality, and long-term implications. While SARS-CoV-2 primarily targets system, recent findings indicate that it also significantly disrupts human microbiome, particularly gut microbiota, contributing to severity, systemic inflammation, immune dysregulation, increased susceptibility secondary infections chronic conditions. Dysbiosis, or microbial imbalance, exacerbates clinical outcomes COVID-19 has been linked long-COVID, condition affecting proportion survivors manifesting with over 200 symptoms across multiple organ systems. Despite growing recognition microbiome alterations COVID-19, precise mechanisms which interacts influences progression remain poorly understood. This narrative review investigates impact on host-microbiota dynamics evaluates its implications severity for developing personalized therapeutic strategies COVID-19. Furthermore, highlights dual role modulating progression, as promising target advancing diagnostic, prognostic, approaches managing

Language: Английский

Citations

0
Efficacy of a Multistrain Synbiotic Treatment in Acute and Post-Acute COVID-19 Patients: A Double-Blind, Placebo-Controlled Randomized Trial DOI Creative Commons
Maria Letizia Giancola, Andrea Fontana, Concetta Panebianco

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1443 - 1443

Published: July 16, 2024

Background and Aims: Several studies reported the effect of COVID-19 on inducing gut dysbiosis, which is also correlated with disease severity. This study aims to investigate a nutraceutical formula shift microbiota profiles and, secondly, clinical–pathological parameters acute post-acute patients. Methods: In this randomised, double-blind, placebo-controlled trial conducted at National Institute for Infectious diseases (INMI) Lazzaro Spallanzani (Italy), 52 patients were randomly assigned (1:1) receive multistrain synbiotic (Kebirah®) or placebo orally 35 days diagnosis. Health professionals, investigators, masked group assignments. The V3–V4 hypervariable region 16S rRNA gene sequencing was employed composition in two groups. Results: Supplementation Kebirah® prevented decrease Shannon diversity index microbiota, instead observed receiving placebo. addition, decreases lymphocyte count haemoglobin levels only not treated group, characterised by an amelioration microbial profile, enrichment beneficial bacteria preservation species diversity. Conclusions: Our data suggest that modulating through administration specific symbiotic could be useful strategy frame SARS-CoV-2 infections.

Language: Английский

Citations

1
Administration of Lactobacillus plantarum GUANKE alleviates SARS-CoV-2-induced pneumonia in mice DOI Creative Commons
He Huang,

Xiaojing Dong,

Z.‐Q. Du

et al.

Microbiology Spectrum, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 21, 2024

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets epithelial cells in the tract, triggering an proinflammatory response and chronic lung inflammation. Probiotic supplementation has shown promise reducing nasopharyngeal SARS-CoV-2 viral load, diminishing symptom frequency duration, mitigating inflammation; thus, it is a potential strategy for treating disease 2019 (COVID-19), which caused by infection. In this study, we evaluated effects of oral administration Lactobacillus plantarum GUANKE strain, gram-positive bacterium originally isolated from healthy individual, on infection human ACE2 transgenic mouse model. We found that significantly reduced inflammatory cell infiltration pulmonary interstitial exudation mice. The transcription CCL2 , TNFA IL1B IL6, IL17C lungs was reduced. protein levels TNF-α, IL-1β, IL-6, IL-17 were lower GUANKE-treated mice than control load saline-treated mice, although difference did not reach statistical significance. L. can decrease SARS-CoV-2-induced inflammation suggesting its use as agent IMPORTANCE Most otherwise individuals develop only mild or moderate symptoms (COVID-19) current strains severe (SARS-CoV-2), virus replication mainly confined to upper tract; however, infect tract promote been reduce overall number duration symptoms, attenuate clinical trials. showed novel strain alleviated pneumonia production cytokines suppressed, moderately load. become candidate drug treatment COVID-19 other infections.

Language: Английский

Citations

1
SARS-CoV-2 and Environmental Changes: The Perfect Storm DOI Creative Commons
Mario Caldarelli, Pierluigi Rio, Vincenzo Giambra

et al.

Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(11), P. 11835 - 11852

Published: Oct. 23, 2024

The COVID-19 pandemic has had a significant impact on the global economy. It also provided insights into how looming climate crisis might be addressed, as there are several similarities between challenges proposed by and those expected from coming emergency. is an immediate health threat, but change represents more gradual insidious risk that will lead to long-term consequences for human health. Research shows change, air pollution pandemics have negative Recent studies show mortality increases with extremes. goal of our review analyze clinical findings they affected while providing insight emergence new variants their ability evade immune system. We selected synthesized data primary studies, reviews, meta-analyses, systematic reviews. Selection was based rigorous methodological relevance criteria. Indeed, variant SARS-CoV-2, named JN.1, emerged dominant, first in United States then worldwide; specific mutations its spike proteins increase transmissibility. According World Health Organization (WHO), JN.1 currently most reported interest (VOI), having been identified 132 countries. highlight link pandemics, emphasizing need action, targeted medical approaches scientific innovation.

Language: Английский

Citations

0