Dual Temperature and pH Sensitive Poly(ethyl methacrylate‐co‐acrylamide) Nanogels Have Potential for Controlled Release of Doxorubicin DOI

Orhun Hakkoymaz,

Hidayet Mazı

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(37)

Published: Sept. 30, 2024

Abstract In this study, the synthesis and characterization of poly(ethyl methacrylate‐ co ‐acrylamide) (i.e., poly(EMA‐ ‐AAm)) nanogels loading release studies doxorubicin hydrochloride were carried out. The was out using emulsion polymerization technique at 60 °C. Swelling experiments showed that sensitive to temperature pH medium. Zeta sizer analysis results synthesized had an average size 23.17 nm PDI value 0.270. into nanogels, drug capacity (DLC) nanogel determined as 32% efficiency (DLE) 77%. Release conducted = 5.4 7.4 37 °C percentage 17% even in 32 h 7.4, 82% 5 5.4. different temperatures revealed °C, 85% 39 89% 41 These ‐AAm) can be used targeted controlled increase effects while reducing side effects.

Language: Английский

Synergistic Effects of Radical Distributions of Soluble and Insoluble Polymers within Electrospun Nanofibers for an Extending Release of Ferulic Acid DOI Open Access

Ran Dong,

Wenjian Gong,

Qiuyun Guo

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2614 - 2614

Published: Sept. 15, 2024

Polymeric composites for manipulating the sustained release of an encapsulated active ingredient are highly sought after many practical applications; particularly, water-insoluble polymers and core–shell structures frequently explored to manipulate behaviors drug molecules over extended time period. In this study, electrospun nanostructures were utilized develop a brand-new strategy tailor spatial distributions both insoluble polymer (ethylcellulose, EC) soluble (polyvinylpyrrolidone, PVP) within nanofibers, thereby extended-release loaded ingredient, ferulic acid (FA). Scanning electron microscopy transmission assessments revealed that all prepared nanofibers had linear morphology without beads or spindles, those from coaxial processes obvious structure. X-ray diffraction attenuated total reflectance Fourier transform infrared spectroscopic tests confirmed FA fine compatibility with EC PVP, presented in amorphous state. vitro dissolution indicated radical (decreasing shell core) PVP (increasing able play their important role elaborately. On one hand, F3 advantages homogeneous composite F1 higher content solutions inhibit initial burst provide longer period release. other F2 core negative tailing-off The key element was water permeation rates, controlled by ratios polymers. new based on structure paves way developing wide variety polymeric heterogeneous realizing desired functional performances.

Language: Английский

Citations

20
Targeted therapeutic strategy for oral squamous carcinoma using celecoxib-loaded GABA/wheat gluten-alginate nanocarrier hydrogel with glutathione down-regulation and enhanced CCND2-mediated apoptosis DOI
Wenlu Li, Peipei Zhang, Hao Fu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140679 - 140679

Published: Feb. 1, 2025

Language: Английский

Citations

1
Interpenetrating Polymer Networks in Biomedical Fields: Recent Advanced and Applications DOI Open Access

Farangis Shahi,

Sara Zarei,

Razhan Salah Othman

et al.

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 1, 2025

ABSTRACT Recent developments in polymer materials have led to an increased implementation of hydrogels biomedical settings, especially the creation smart hydrogels. Traditional single‐network often exhibit challenges, such as poor mechanical strength, insufficient biocompatibility, and slow response rates. To address these issues, researchers introduced Interpenetrating Polymer Network (IPN) hydrogels, which significantly improve strength via topological entanglements physical interactions. This dual‐network design not only enhances biocompatibility but also responsiveness stimuli, endowing with distinctive properties like cell adhesion, conductivity, hemostatic functions, antioxidant abilities, color‐changing properties. The purpose this article is elucidate factors that trigger stimuli IPN their impacts on cellular behavior, various applications they can serve. A comprehensive overview provided regarding classification, mechanisms, performance attributes, related subjects. Ultimately, review emphasizes promise hold fulfilling increasing need for innovative improved features sector.

Language: Английский

Citations

0
Targeting cell signaling pathway ALKBH5/Beclin1/ULK1 in lung cancer by 5-flurouracil- loaded P (AAm/SA) nanogel in rats DOI
Ahmad S. Kodous,

Eman Salah Eldin,

Hebatallah E. Mohamed

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
LC-MS/MS Profiling and Immunomodulatory Potential of Green-Synthesized Zinc Oxide Nanoparticles Using Cordia sebestena Leaves Against Chromium-Induced Acute Lung Injury in Rats. DOI
Nabil A. Shoman, Abeer Salama, Farrakh Ali Abbas

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106750 - 106750

Published: Feb. 1, 2025

Language: Английский

Citations

0
Design, nanogel synthesis, anti-proliferative activity and in silico ADMET profile of pyrazoles and pyrimidines as topo-II inhibitors and DNA intercalators DOI Creative Commons
Ahmed K. B. Aljohani,

Sanadelaslam S. A. El‐Hddad,

Marwa Alsulaimany

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(13), P. 10037 - 10048

Published: Jan. 1, 2025

Pyrazole derivatives 2 and 3, pyrimidine derivative 4, their nanogels as drug delivery systems were synthesized, cytotoxicity against MCF-7, HCT-116, HepG2 A549 cells was evaluated.

Language: Английский

Citations

0
Radiation-induced nanogel engineering based on pectin for pH-responsive rutin delivery for cancer treatment DOI Creative Commons
Khaled El‐Adl, Mohamed Mohamady Ghobashy, Amel F.M. Ismail

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

This research investigates the formulation of a nanogel complex using pectin and poly(acrylic acid) (PAAc) to encapsulate rutin. The nanogel's pH-responsive behavior its potential as targeted drug delivery platform are investigated. gamma irradiation-induced crosslinking mechanism is elucidated, highlighting role in creating stable three-dimensional network structure within polymer matrix. Fourier transform infrared spectroscopy analysis sheds light on molecular interactions rutin nanogel-rutin complex. explored, showcasing ability release selectively response pH variations displaying high physical chemical stability. Transmission electron microscopy imaging provides visual insights into morphology interactions. cumulative content from was 86.14 ± 2.61%. pH-dependent profile examined, demonstrating selective varying levels. Cytotoxicity studies were conducted against four human cancer cell lines-HepG2, A549, MCF-7, HCT-116 showing significant reductions IC

Language: Английский

Citations

2
Dual Temperature and pH Sensitive Poly(ethyl methacrylate‐co‐acrylamide) Nanogels Have Potential for Controlled Release of Doxorubicin DOI

Orhun Hakkoymaz,

Hidayet Mazı

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(37)

Published: Sept. 30, 2024

Abstract In this study, the synthesis and characterization of poly(ethyl methacrylate‐ co ‐acrylamide) (i.e., poly(EMA‐ ‐AAm)) nanogels loading release studies doxorubicin hydrochloride were carried out. The was out using emulsion polymerization technique at 60 °C. Swelling experiments showed that sensitive to temperature pH medium. Zeta sizer analysis results synthesized had an average size 23.17 nm PDI value 0.270. into nanogels, drug capacity (DLC) nanogel determined as 32% efficiency (DLE) 77%. Release conducted = 5.4 7.4 37 °C percentage 17% even in 32 h 7.4, 82% 5 5.4. different temperatures revealed °C, 85% 39 89% 41 These ‐AAm) can be used targeted controlled increase effects while reducing side effects.

Language: Английский

Citations

0