Targeting accelerated pulmonary ageing to treat chronic obstructive pulmonary disease‐induced neuropathological comorbidities DOI Creative Commons
Simone N. De Luca, Ross Vlahos

British Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 181(1), P. 3 - 20

Published: Oct. 13, 2023

Abstact Chronic obstructive pulmonary disease (COPD) is a major incurable health burden, ranking as the third leading cause of death worldwide, mainly driven by cigarette smoking. COPD characterised persistent airway inflammation, lung function decline and premature ageing with presence senescent cells. This review proposes that cellular senescence, state stable cell cycle arrest linked to ageing, induced inflammation oxidative stress in COPD, extends beyond lungs affects systemic circulation. profile will reach other organs via extracellular vesicles contributing brain damage, increasing risk neurological comorbidities, such stroke, cerebral small vessel Alzheimer's disease. The explores role senescence COPD‐associated conditions investigates relationship between circadian rhythm COPD. Additionally, it discusses potential therapies, including senomorphic senolytic treatments, novel strategies halt or improve progression

Language: Английский

Circadian rhythm disruption in critically ill patients DOI Creative Commons
Matthias Felten, Christof Dame, Gunnar Lachmann

et al.

Acta Physiologica, Journal Year: 2023, Volume and Issue: 238(1)

Published: March 14, 2023

Abstract Patients admitted to the intensive care unit (ICU) are in need of continuous organ replacement strategies and specialized care, for example because neurological dysfunction, cardio‐pulmonary instability, liver or kidney failure, trauma, hemorrhagic septic shock even preterm birth. The 24‐h nursing interventions provided critically ill patients significantly limit resting and/or recovery phases. Consecutively, patient's endogenous circadian rhythms misaligned disrupted, which turn may interfere with their critical condition. A more thorough understanding complex interactions effectors tissue‐specific molecular clocks could therefore serve as potential means enhancing personalized treatment patients, conceivably restoring network thus accelerating physical neurocognitive recovery. This review addresses overarching issue how affected disturbed newborns adults ICU, whether conflicting external environmental cues ICU environment further promote disruption severity illness. We direct special attention influence cell‐type specific on dysfunctions such brain pneumonia‐ ventilator‐associated lung inflammation, cardiovascular shock. Finally, we address rhythm stabilization enhance accelerate clinical

Language: Английский

Citations

24
Circadian clock molecule REV-ERBα regulates lung fibrotic progression through collagen stabilization DOI Creative Commons
Qixin Wang, Isaac K. Sundar,

Joseph H. Lucas

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: March 9, 2023

Abstract Molecular clock REV-ERBα is central to regulating lung injuries, and decreased abundance mediates sensitivity pro-fibrotic insults exacerbates fibrotic progression. In this study, we determine the role of in fibrogenesis induced by bleomycin Influenza A virus (IAV). Bleomycin exposure decreases REV-ERBα, mice dosed with at night display exacerbated fibrogenesis. Rev-erbα agonist (SR9009) treatment prevents collagen overexpression mice. global heterozygous (Rev-erbα Het) infected IAV showed augmented levels collagens lysyl oxidases compared WT-infected Furthermore, (GSK4112) oxidase TGFβ human fibroblasts, whereas antagonist it. Overall, these results indicate that loss responses promoting expression, This study provides potential agonists pulmonary fibrosis.

Language: Английский

Citations

20
Association of rest-activity circadian rhythm with chronic respiratory diseases, a cross-section survey from NHANES 2011–2014 DOI

Wenbo Gu,

Zhen Tian,

Wei Tian

et al.

Respiratory Medicine, Journal Year: 2023, Volume and Issue: 209, P. 107147 - 107147

Published: Feb. 6, 2023

Language: Английский

Citations

18
The circadian clock and extracellular matrix homeostasis in aging and age-related diseases DOI
Michal Dudek, Joe Swift, Qing‐Jun Meng

et al.

AJP Cell Physiology, Journal Year: 2023, Volume and Issue: 325(1), P. C52 - C59

Published: May 29, 2023

The extracellular matrix (ECM) is the noncellular scaffolding component present within all tissues and organs. It provides crucial biochemical biomechanical cues to instruct cellular behavior has been shown be under circadian clock regulation, a highly conserved cell-intrinsic timekeeping mechanism that evolved with 24-hour rhythmic environment. Aging major risk factor for many diseases, including cancer, fibrosis, neurodegenerative disorders. Both aging our modern 24/7 society disrupt rhythms, which could contribute altered ECM homeostasis. Understanding daily dynamics of how this changes age will have profound impact on tissue health, disease prevention, improving treatments. Maintaining oscillations proposed as hallmark health. On other hand, hallmarks turn out key regulators mechanisms. In review, we summarize new work linking clocks aging. We discuss in properties during may dysregulation. also consider dampening compromise dynamic regulation homeostasis matrix-rich tissues. This review aims encourage concepts testable hypotheses about two-way interactions between context

Language: Английский

Citations

16
Associations between long-term night shift work and incidence of chronic obstructive pulmonary disease: a prospective cohort study of 277,059 UK Biobank participants DOI Creative Commons
Jia Li, Liangle Yang, Yuxin Yao

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 16, 2024

Abstract Background Little is known about the effects of night shifts and their interactions with genetic factors on chronic obstructive pulmonary disease (COPD). In this study, we aim to investigate relationships between long-term shift work exposure COPD risk, assess modification predisposition. Methods A total 277,059 subjects who were in paid employment or self-employed included UK Biobank. Information current lifetime was obtained, a weighted COPD-specific risk score (GRS) constructed. We used Cox proportional hazard models associations interaction GRS. Results The cohort study participants (133,063 men [48.03%]; mean [SD] age, 52.71 [7.08] years). During median follow-up 12.87 years, documented 6558 incidents COPD. From day work, irregular regular shifts, there an increased trend incidence ( P for < 0.001). Compared workers, ratio (HR) 95% confidence interval (CI) 1.28 (1.20, 1.37) rarely/sometimes 1.49 (1.35, 1.66) those permanent shifts. Besides, longer durations (especially ≥ 10 years) increasing monthly frequency (in workers > 8 nights/month) associated higher risk. Additionally, additive susceptibility Subjects high had highest (HR: 1.90 [95% CI: 1.63, 2.22]), low as reference. Conclusions Long-term Our findings suggest that decreasing duration may offer promising approach mitigating respiratory particularly light individual susceptibility.

Language: Английский

Citations

4
Resetting of the Human Circadian Melatonin Rhythm by Ambient Hypoxia DOI
Titiaan E. Post,

Riccardo De Gioannis,

Jan Schmitz

et al.

Journal of Pineal Research, Journal Year: 2025, Volume and Issue: 77(1)

Published: Jan. 1, 2025

ABSTRACT Circadian clocks in the body drive daily cycles physiology and behavior. A master clock brain maintains synchrony with environmental day–night cycle uses internal signals to keep other tissues aligned. Work cell cultures uncovered cyclic changes tissue oxygenation that may serve reset synchronize circadian clocks. Here we show healthy humans, following a randomized controlled single‐blind counterbalanced crossover study design, one‐time exposure moderate ambient hypoxia (FiO 2 ~15%, normobaric) for ~6.5 h during early night advances dim‐light onset of melatonin secretion by 9 min (95% CI: 1–16 min). Exposure thus be strong enough entrain 24‐h absence entraining cues. Together, results provide direct evidence an interaction between body's hypoxia‐sensing pathway The finding offers mechanism through which behaviors change (e.g., exercise fasting/eating) can affect timing hypoxia‐related diseases obstructive sleep apnea chronic pulmonary disease) result misalignment associated pathologies. Trial Registration: Registration number: DRKS00023387; German Clinical Trials Register: http://www.drks.de

Language: Английский

Citations

0
Association of circadian syndrome and lung health: A population-based cohort study DOI

Shuwen Zhang,

Jiangtao Lin

Respiratory Medicine, Journal Year: 2025, Volume and Issue: 240, P. 108031 - 108031

Published: March 9, 2025

Language: Английский

Citations

0
The circadian clock at the intersection of metabolism and aging – emerging roles of metabolites DOI Creative Commons
Yue Dong, Sin Man Lam, Yan Li

et al.

Journal of genetics and genomics/Journal of Genetics and Genomics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
The Critical Role of Sleep in Enhancing Pulmonary Rehabilitation Outcomes DOI
Mario Henríquez‐Beltrán, Jessica M Gonzalez, Gonzalo Labarca

et al.

Seminars in Respiratory and Critical Care Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 31, 2025

Abstract Pulmonary rehabilitation is a comprehensive, interdisciplinary intervention that aims to enhance the physical and psychological well-being of individuals with chronic respiratory diseases. This approach entails implementation tailored therapies, including exercise training, education, behavioral modification. Sleep plays crucial role in numerous physiological processes, regulation inflammation tissue repair, both which are fundamental efficacy rehabilitation. A paucity optimal sleep health has been associated deleterious effects on pivotal factors indispensable for favorable outcomes pulmonary rehabilitation, mental immune function. This, turn, may increase susceptibility impaired The integration protocols healthy practices expected yield significant improvements lung function overall health, will, promote long-term adherence rehabilitative behaviors. study examine relationship between outcomes.

Language: Английский

Citations

0
Aging-Related Mechanisms Contribute to Corticosteroid Insensitivity in Elderly Asthma DOI Open Access
M.L. Ford, Anushka Ruwanpathirana, Brandon W. Lewis

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6347 - 6347

Published: March 28, 2023

Asthma in elderly populations is an increasing health problem that accompanied by diminished lung function and frequent exacerbations. As potent anti-inflammatory drugs, corticosteroids are commonly used to reduce inflammation, improve function, manage disease symptoms asthma. Although effective for most individuals, older patients more insensitive corticosteroids, making it difficult asthma this population. With the number of individuals than 65 continuing increase, important understand distinct mechanisms promote corticosteroid insensitivity aging lung. In review, we discuss with emphasis on contribute persistent inflammation individuals.

Language: Английский

Citations

8