Journal of Applied Microbiology,
Journal Year:
2023,
Volume and Issue:
134(7)
Published: July 1, 2023
Blue
pigments
have
broad
applications
in
foods,
cosmetics,
and
clothing.
However,
natural
blue
are
rare.
At
present,
the
majority
of
for
sale
chemically
synthetic.
Owing
to
safety
risks
chemical
pigments,
it
is
an
urgent
demand
develop
novel
pigments.The
fermentation
medium
culture
conditions
pigment
produced
by
Quambalaria
cyanescens
QY229
were
optimized
Plackett-Burman
(PB)
experimental
design
response
surface
methodology
(RSM)
first
time.
The
stability,
bioactivity,
toxicity
obtained
studied
after
isolation
purification.The
results
showed
that
optimal
parameters
34.61
g·L-1
peptone
concentration,
31.67°C
growing
temperature,
72.33
mL
volume
a
250-mL
flask,
yield
reached
348.2
±
7.1
U·mL-1.
stable
light,
heat,
pH,
most
metal
ions,
additives,
has
certain
antioxidant
inhibitory
activity
α-glucosidase
vitro.
at
concentrations
0-1.25
mg·mL-1
was
nontoxic
Caenorhabditis
elegans
acute
trial.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(12), P. 8049 - 8089
Published: Jan. 1, 2023
Microorganisms
still
remain
the
main
hotspots
in
global
drug
discovery
avenue.
In
particular,
fungi
are
highly
prolific
producers
of
vast
structurally
diverse
specialized
secondary
metabolites,
which
have
displayed
a
myriad
biomedical
potentials.
Intriguingly,
isocoumarins
is
one
distinctive
class
fungal
natural
products
polyketides,
demonstrated
numerous
remarkable
biological
and
pharmacological
activities.
This
review
article
provides
comprehensive
state-of-the-art
over
period
2000-2022
about
discovery,
isolation,
classifications,
therapeutic
potentials
exclusively
reported
from
fungi.
Indeed,
list
351
were
documented
classified
according
to
their
sources
[16
order/28
family/55
genera]
where
they
been
originally
discovered
along
with
activities
wherever
applicable.
Also,
recent
insights
around
proposed
experimentally
proven
biosynthetic
pathways
also
briefly
discussed.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(2), P. 425 - 425
Published: Jan. 15, 2024
Cancer
is
one
of
the
leading
causes
death
worldwide,
with
breast
cancer
being
second
cause
cancer-related
mortality
among
women.
Natural
Products
(NPs)
are
main
sources
for
drug
discovery.
During
a
screening
campaign
focused
on
identification
extracts
from
Fundación
MEDINA’s
library
inhibiting
proliferation
cell
lines,
significant
bioactivity
was
observed
in
cultures
fungus
Angustimassarina
populi
CF-097565.
Bioassay-guided
fractionation
this
extract
led
to
and
isolation
herbarin
(1),
1-hydroxydehydroherbarin
(4)
plus
other
three
naphthoquinone
derivatives
which
3
5
new
natural
products
2
herein
described
source
first
time.
Four
these
compounds
(1,
3,
4
5)
confirmed
specific
cytotoxic
effect
against
human
line
MCF-7.
To
evaluate
therapeutic
potential
isolated,
their
efficacy
validated
3D
cultures,
model
higher
functionality.
Additionally,
an
in-depth
study
carried
out
test
terms
mortality,
sphere
disaggregation,
shrinkage,
morphology.
The
profile
also
compared
that
known
aim
distinguish
mode
action
(MoA).
profiles
1,
showed
more
biosimilarity
between
them,
different
5,
even
agents,
suggesting
alternative
MoA
responsible
cytotoxicity
cultures.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(39), P. 27477 - 27490
Published: Jan. 1, 2023
It
has
been
reported
that
organic
extracts
derived
from
soft
corals
belonging
to
the
genus
Sarcophyton
have
exhibited
a
wide
range
of
therapeutic
characteristics.
Based
on
biochemical
and
histological
techniques,
we
aimed
assess
hepatoprotective
role
extract
its
principal
steroidal
contents
Red
Sea
coral
glaucum
acetaminophen-induced
liver
fibrosis
in
rats.
Serum
function
parameters
(ALT,
AST,
ALP
total
bilirubin)
were
quantified
using
spectrophotometer,
both
alpha-fetoprotein
(AFP)
carcinoembryonic
antigen
(CEA)
levels
determined
by
enzyme-linked
immunosorbent
assay
(ELISA)
kits
while
transformed
growth
factor
beta
(TGF-β)
tumor
necrosis
α
(TNF-α)
tissue
homogenate
ELISA,
TGF-β
TNF-α
gene
expression
was
real-time
PCR
following
extraction
purification.
Histopathological
alterations
hepatic
also
examined
under
microscope.
In
order
prioritize
isolation
characterization
most
promising
marine
steroids
as
agents,
computational
approach
employed.
This
involved
molecular
docking
(MDock)
analysis
structure-activity
relationship
(SAR)
against
glutathione-S-transferase
(GST)
Cu-Zn
human
superoxide
dismutase
(Cu-ZnSOD)
enzymes.
Although
major
detoxification
foreign
chemicals
toxic
metabolites
GST
SOD
enzymes
is
known,
there
lack
knowledge
about
mode
action
process
those
targets
involved.
The
present
study
investigated
multiple
interactions
series
with
enzymes,
reveal
insights
into
hepatoprotection.
PLoS neglected tropical diseases,
Journal Year:
2024,
Volume and Issue:
18(9), P. e0012453 - e0012453
Published: Sept. 12, 2024
Schistosomiasis,
also
known
as
bilharzia
or
snail
fever,
is
a
tropical
parasitic
disease
resulting
from
flatworms
of
the
Schistosoma
genus.
This
often
overlooked
has
significant
impacts
in
affected
regions,
causing
enduring
morbidity,
hindering
child
development,
reducing
productivity,
and
creating
economic
burdens.
Praziquantel
(PZQ)
currently
only
treatment
option
for
schistosomiasis.
Given
potential
rise
drug
resistance
limited
choices
available,
there
need
to
develop
more
effective
inhibitors
this
neglected
(NTD).
In
view
this,
quantitative
structure-activity
relationship
studies
(QSAR),
molecular
docking,
dynamics
simulations,
drug-likeness,
ADMET
predictions
were
applied
31
mansoni
Dihydroorotate
dehydrogenase
(SmDHODH).
The
designed
QSAR
model
demonstrated
robust
statistical
parameters
including
an
R
2
0.911,
adj
0.890,
Q
cv
0.686,
pred
0.807,
cR
p
0.825,
confirming
its
robustness.
Compound
26
,
identified
most
active
derivative,
emerged
lead
candidate
new
through
ligand-based
design.
Subsequently,
12
novel
compounds
(
26A
-
26L
)
with
enhanced
inhibition
activity
binding
affinity.
Molecular
docking
revealed
strong
stable
interactions,
hydrogen
bonding
hydrophobic
between
target
receptor.
simulations
over
100
nanoseconds
MM-PBSA
free
energy
(ΔG
bind
calculations
validated
stability
two
best-designed
molecules
).
Furthermore,
drug-likeness
prediction
analyses
affirmed
these
compounds,
suggesting
their
promise
innovative
agents
treating
Natural Product Reports,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Cytochalasans
are
fungal
natural
products
with
diverse
structures
and
biomedical
potential.
This
review
explores
their
diversity,
biosynthesis,
pharmacokinetics,
drug-likeness,
therapeutic
Results in Chemistry,
Journal Year:
2023,
Volume and Issue:
6, P. 101138 - 101138
Published: Oct. 10, 2023
Naphthoquinones
are
secondary
plant
metabolites
that
used
to
treat
a
variety
of
human
ailments
in
traditional
medicine.
In
light
this,
the
synthesis
derivatives
naphthoquinone
has
been
investigated
include
substances
with
potential
biological
processes.
It
claimed
adding
chemical
groups
such
as
amines,
amino
acids,
furan,
pyran,
pyrazole,
triazole,
and
indole
increases
pharmacological
effects
naphthoquinones.
Drugs
based
on
1,4
ring-containing
moieties
have
attracted
lot
interest
lately
because
their
wide
range
activity
possible
therapeutic
uses.
This
article
offers
thorough
overview
ring
containing
synthesizing
methods
The
creation
scaffolds
was
accomplished
using
techniques,
including
both
contemporary
green
chemistry
techniques.
addition,
characteristics
medications
number
disease
states,
cancer,
infectious
illnesses,
cardiovascular
disorders,
neurological
diseases.
