Antibiotic-Induced dysbiosis of the ocular microbiome affects corneal circadian rhythmic activity in mice

Mucosal Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Impact of COVID-19 on Ocular Surface Health: Infection Mechanisms, Immune Modulation, and Inflammatory Responses

Viruses, Journal Year: 2025, Volume and Issue: 17(1), P. 68 - 68

Published: Jan. 6, 2025

COVID-19, caused by SARS-CoV-2, has presented formidable challenges to global health since its emergence in late 2019. While primarily known for respiratory symptoms, it can also affect the ocular surface. This review summarizes effects of SARS-CoV-2 on surface immunity and inflammation, focusing infection mechanisms, immune responses, clinical manifestations. Ocular though uncommon, include conjunctivitis, dry eye, blurred vision. binds ACE2 receptors epithelial cells, facilitating viral entry, replication, local dissemination. The innate responses involving corneal cells are discussed, alongside mechanisms antigen presentation adaptive immunity. examines roles cytokines chemokines mediating inflammation explores impact cytokine storms chronic health. Additionally, interplay between systemic is highlighted, analyzing how COVID-19 influences These insights underscore broader implications beyond localized infection. By consolidating current findings, this aims guide preventive therapeutic strategies while identifying directions future research mitigate consequences COVID-19.

Language: Английский

Restorative Effects of Short-Chain Fatty Acids on Corneal Homeostasis Disrupted by Antibiotic-Induced Gut Dysbiosis

American Journal Of Pathology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский