Nigerian Journal of Clinical Practice,
Journal Year:
2024,
Volume and Issue:
27(12), P. 1473 - 1478
Published: Dec. 1, 2024
Background:
Benign
epilepsy
with
centrotemporal
spikes
(BECTS)
is
a
common
form
of
in
childhood.
In
some
patients
BECTS,
electrical
status
epilepticus
sleep
(ESES)
may
develop,
and
ESES
can
also
be
present
children
different
types
structural
brain
lesions.
BECTS
ESES,
where
conventional
magnetic
resonance
imaging
(MRI)
findings
are
normal,
the
results
microstructural
examinations
thalamus
differ.
Aim:
The
main
aim
this
study
was
to
investigate
anatomical
differences
using
MRI-Cloud,
more
objective
quantitative
evaluation
method,
which
has
been
done
for
first
time
literature.
Methods:
We
included
27
healthy
controls
study.
analyzed
subcortical
gray
matter
volumes
diagnosed
via
“MRI-Cloud”
method.
Limitations
our
were
small
sample
size.
Results:
Total
relative
thalamic
volume
significantly
lower
than
(
P
<
0.001)
,
total
without
.
Thalamic
reduced
group
compared
control
group,
both
right
left
thalami
showing
0.001).
addition,
had
markedly
smaller
those
(right
thalami,
Conclusion:
study,
we
emphasize
contribution
analysis
MRI-Cloud
method
detecting
changes
at
level
even
when
MRI
normal.
Neurology,
Journal Year:
2023,
Volume and Issue:
102(3)
Published: Dec. 28, 2023
The
idiopathic
generalized
epilepsies
(IGE)
make
up
a
fifth
of
all
epilepsies,
but
<1%
epilepsy
research.
This
skew
reflects
misperceptions:
diagnosis
is
straightforward,
pathophysiology
understood,
seizures
are
easily
controlled,
outgrown,
morbidity
and
mortality
low,
surgical
interventions
impossible.
Emerging
evidence
reveals
that
patients
with
IGE
may
go
undiagnosed
or
misdiagnosed
focal
if
EEG
semiology
have
asymmetric
features.
Genetic,
electrophysiologic,
neuroimaging
studies
provide
insights
into
pathophysiology,
including
overlaps
differences
from
epilepsies.
can
begin
in
adulthood
chronic
drug-resistant
seizures.
Neuromodulatory
for
emerging.
Rates
psychiatric
other
comorbidities,
sudden
unexpected
death
epilepsy,
parallel
those
epilepsy.
an
understudied
spectrum
which
our
diagnostic
sensitivity
specificity,
scientific
understanding,
therapies
remain
inadequate.
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(7), P. 648 - 648
Published: June 27, 2024
The
central
nervous
system
(CNS)
exhibits
remarkable
adaptability
throughout
life,
enabled
by
intricate
interactions
between
neurons
and
glial
cells,
in
particular,
oligodendrocytes
(OLs)
oligodendrocyte
precursor
cells
(OPCs).
This
is
pivotal
for
learning
memory,
with
OLs
OPCs
playing
a
crucial
role
neural
circuit
development,
synaptic
modulation,
myelination
dynamics.
Myelination
not
only
supports
axonal
conduction
but
also
undergoes
adaptive
modifications
response
to
neuronal
activity,
which
vital
cognitive
processing
memory
functions.
review
discusses
how
these
cellular
myelin
dynamics
are
implicated
various
neurocircuit
diseases
disorders
such
as
epilepsy,
gliomas,
psychiatric
conditions,
focusing
on
maladaptive
changes
contribute
disease
pathology
influence
clinical
outcomes.
It
covers
the
potential
new
diagnostics
therapeutic
approaches,
including
pharmacological
strategies
emerging
biomarkers
functions
processes.
evidence
fundamental
plasticity
functionality
synchronizing
activity
high-level
functions,
offering
promising
avenues
targeted
interventions
CNS
disorders.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 28, 2024
ABSTRACT
Traumatic
brain
injury
(TBI)
is
a
leading
cause
of
mortality
and
disability
worldwide
can
lead
to
secondary
sequelae
such
as
increased
seizure
susceptibility.
Emerging
work
suggests
that
the
thalamus,
relay
center
undergoes
damage
after
cortical
TBI,
involved
with
heightened
risks
TBI.
TBI
also
induces
recruitment
peripheral
immune
cells,
including
T
site(s)
injury,
but
it
unclear
how
these
cells
impact
neurological
post-TBI.
Here,
we
characterize
identities
kinetics
lymphocytic
infiltrates
into
cortex
thalamus
using
mouse
model
We
identify
population
IFNγ-producing
type
1
lymphocytes
infiltrate
specific
thalamic
subregions
over
weeks
following
where
they
elicit
local
IFNγ
response
in
microglia
neuronal
subset(s).
Depletion
CD4
+
protects
mice
from
TBI-induced
susceptibility
by
de-repressing
other
non-CD4
disease-associated
(DAMs)
thalamus.
Strikingly,
find
single
dose
prior
challenge
proconvulsant
agent
was
sufficient
reduce
incidence,
severity,
mortality.
This
identifies
direct
modulator
TBI-associated
susceptibility,
which
could
have
therapeutic
implications
for
treatment
patients.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9869 - 9869
Published: Sept. 12, 2024
Approximately
30%
of
patients
with
epilepsy
are
drug-refractory.
There
is
an
urgent
need
to
elucidate
the
exact
pathophysiology
different
types
epilepsies
and
mechanisms
action
both
antiseizure
medication
metabolic
therapies
treat
more
effectively
safely.
For
example,
it
has
been
demonstrated
that
exogenous
ketone
supplement
(EKS)-generated
therapeutic
ketosis,
as
a
therapy,
may
decrease
epileptic
activity
in
animal
models
humans,
but
its
mechanism
unknown.
However,
was
among
others,
can
increase
adenosine
level,
which
enhance
A1
receptors
(A
