Potential Role of Bmal1 in Lipopolysaccharide-Induced Depression-Like Behavior and its Associated "Inflammatory Storm"

Journal of Neuroimmune Pharmacology, Journal Year: 2024, Volume and Issue: 19(1)

Published: Feb. 2, 2024

Language: Английский

---

Multimodal digital assessment of depression with actigraphy and app in Hong Kong Chinese

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 18, 2024

Abstract There is an emerging potential for digital assessment of depression. In this study, Chinese patients with major depressive disorder (MDD) and controls underwent a week multimodal measurement including actigraphy app-based measures (D-MOMO) to record rest-activity, facial expression, voice, mood states. Seven machine-learning models (Random Forest [RF], Logistic regression [LR], Support vector machine [SVM], K-Nearest Neighbors [KNN], Decision tree [DT], Naive Bayes [NB], Artificial Neural Networks [ANN]) leave-one-out cross-validation were applied detect lifetime diagnosis MDD non-remission status. Eighty subjects 76 age- sex-matched completed the actigraphy, while 61 47 assessment. had lower mobile time ( P = 0.006), later sleep midpoint 0.047) Acrophase 0.024) than controls. For app measurement, more frequent brow lowering 0.023), less lip corner pulling 0.007), higher pause variability 0.046), self-reference negative emotion words 0.002), articulation rate < 0.001) happiness level With fusion all modalities, predictive performance (F1-score) ANN was 0.81 0.70 status when combined HADS-D item score, respectively. Multimodal feasible diagnostic tool depression in Chinese. A combination approach has enhanced markers phenotyping MDD.

Language: Английский

---

Actigraphy-derived circadian rhythms, sleep-wake patterns, and physical activity across clinical stages and pathophysiological subgroups in young people presenting for mental health care

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: 186, P. 396 - 406

Published: March 5, 2025

Staging models for youth mental health aim to locate clinical presentations on a spectrum from at-risk states persistent disorder and predict future illness trajectories. Our previous publications trans-diagnostic staging proposed three pathophysiological subgroups of major mood or psychotic disorders in ('hyperarousal-anxious depression', 'circadian-bipolar spectrum', 'neurodevelopmental-psychosis'). This study aims investigate differences objective measures 24hr sleep-wake patterns, circadian rhythms, physical activity across stages subgroups. Actigraphy data (median: 13 days) was collected 497 presenting care (21.6 ± 4.7 years, 37% male) 88 controls (24.1 3.8 44% male). estimates were compared groups using analysis covariance adjusting age sex. Compared with earlier stages, later significantly associated longer sleep duration(η2 = 0.04), midpoint(η2 0.02), lower regularity(η2 relative amplitude the rest-activity cycle(η2 0.05), higher interdaily stability(η2 0.03), total activity(η2 0.08) less moderate-vigorous 0.06). controls, spectrum' subgroup had 0.03); 'neurodevelopmental-psychosis' 'hyperarousal-anxious depression' subtype 0.02). The findings suggest patterns according stage trajectory subtypes. cross-sectional associations regularity highlight need longitudinal explorations how rhythms interact treatment factors progression both illness.

Language: Английский

---

The potential of using actimetry to identify objective markers of depression

Biological Rhythm Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: March 13, 2025

Language: Английский

---

Temporal pathways between circadian rhythm, depression and anxiety in the transition from adolescence to early adulthood

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 350, P. 656 - 664

Published: Jan. 18, 2024

Sleep and circadian rhythm problems intertwine with affective disorders. Adolescents are particularly vulnerable to developing sleep problems. Yet, the temporal pathways between rhythm, depression anxiety in transition phase from adolescence early adulthood not fully understood. 233 adolescents (76 % females) participated at two time points (T1 T2) an interval of 19-months (aged 16.8 18.4 years). We used The Beck Depression Inventory-II, Generalized Anxiety Disorder Assessment, GENEActiv actigraphy across 8 days (delayed (DSP), duration, midpoint, regularity), iButton 1922L thermologgers 3 (intrinsic period length, amplitude, mesor). A shorter duration T1 associated increase T2, irregularity T2. longer males' Moderate severe a 2.69-fold risk (95 CI 1.38–5.26, p = 0.004) 2.11-fold 1.04–4.25, 0.038) poor quality generalized 3.17-fold 1.35–7.41, 0.008) DSP follow-up is short. results revealed bidirectional links Novel observations include heightened future following current disorder measured 24-hour temperature variation males.

Language: Английский

---

Actigraphic monitoring of sleep and circadian rest-activity rhythm in individuals with major depressive disorder or depressive symptoms: A meta-analysis

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 361, P. 224 - 244

Published: June 7, 2024

Language: Английский

---

Activation differentiates illness trajectories among youth seeking mental health care.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

---

Negative impact of insufficient sleep on the brain

Brain-Apparatus Communication A Journal of Bacomics, Journal Year: 2025, Volume and Issue: 4(1)

Published: April 25, 2025

Language: Английский

---

Twenty-four-hour Skin Temperature Rhythms in Young People With Emerging Mood Disorders: Relationships With Illness Subtypes and Clinical Stage

Journal of Biological Rhythms, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

While circadian disruptions are common in some sub-groups of youth with mood disorders, skin temperature rhythms these cohorts understudied. We examined 24-h wrist emerging exploring associations clinical stage and proposed illness subtypes. Youth ( n = 306, 23.42 ± 4.91 years, 65% females) accessing mental health care 48 healthy controls (23.44 3.38 60% were examined. Skin parameters including rhythm-adjusted mean temperature, inter-daily stability (day-to-day consistency), intra-daily variability (rhythm fragmentation), peak time derived from a wearable sensor. Based on our trajectory-pathophysiology model, participants classified by disorder subtypes (“hyperarousal-anxious” [ 209], “neurodevelopmental-psychosis” 40], or “circadian-bipolar spectrum” 43]), as well (subthreshold disorders classed 1a 1b 47, 173, respectively], full-threshold 2+ 76]). Compared to controls, had delayed, less stable, more variable rhythms, indicated lower (29.94 0.10 °C vs 31.04 0.25 °C, p < 0.001), delayed timing (0533 0014 0332 0036, 0.002), reduced 0.009), increased 0.020). Peak also occurred later relative sleep midpoint (0.31 0.14 −0.48 0.35 radians, 0.037). The subtype exhibited amplitude (0.07 0.005 0.08 0.002 [hyperarousal-anxious] 0.09 [neurodevelopmental-psychosis], 0.039), no delay midpoint. Clinical stages not associated differences parameters. These findings highlight the potential use non-invasive biomarker disturbances disorders. observed patterns rhythmicity support notion that disrupted may mediate onset course subgroups major

Language: Английский

---

Underlying biological mechanisms of emotion dysregulation in bipolar disorder

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: May 9, 2025

Difficulties with emotion regulation (ER) are a key feature of bipolar disorder (BD) contributing to poor psychosocial and functional outcomes. Abnormalities within processing thus provide targets for treatment strategies have implications response. Although biological mechanisms ER typically studied independently, emergent findings in BD research suggest that there important ties between the disturbances observed BD. Therefore, this narrative review, we an overview literature on underlying emotional dysregulation including genetic epigenetic mechanisms, neuroimaging findings, inflammation, hypothalamic-pituitary-adrenal (HPA) axis dysfunction, neuroplasticity brain-derived neurotrophic factor (BDNF), circadian rhythm disturbances. Finally, discuss clinical relevance future directions research. The continued exploration ED may not only elucidate fundamental neurobiological but also foster advancements current development novel targeted treatments.

Language: Английский

---