Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: May 12, 2025
Background
Biological
aging,
a
fundamental
process
affecting
health
and
longevity,
is
pivotal
to
understanding
the
physiological
decline
associated
with
aging.
Serum
vitamin
D3
deficiency
cognitive
impairment
are
common
issues
among
older
adults.
However,
joint
associations
of
serum
D
levels
biological
aging
remain
poorly
understood.
This
study
aims
evaluate
independent
combined
in
Methods
cross-sectional
included
adults
aged
60
years
from
2011–2014
National
Health
Nutrition
Examination
Survey
(NHANES).
was
measured
using
Phenotypic
Age
calculated
biomarkers.
Cognitive
performance
assessed
Centre
for
Establishment
Registry
Alzheimer’s
Disease
(CERAD)
test,
Animal
Fluency
test
(AFT),
Digit
Symbol
Substitution
(DSST).
Multivariable
regression
restricted
cubic
spline
models
were
used
examine
relationships
between
25(OH)D3
levels,
performance,
Results
After
adjusting
all
covariates,
individuals
highest
quartile
had
reduced
risk
compared
those
lowest
(CERAD:
OR
0.91;
95%
CI,
0.57–1.46;
AFT:
0.48;
0.29–0.82;
DSST:
0.43;
0.24–0.77).
A
U-shaped
relationship
observed
Combined
analyses
revealed
that
both
low
across
tests
1.43;
1.02–1.98;
1.70;
1.24–2.32;
1.67;
1.22–2.27).
Notably,
DSST,
normal
showed
reduction
by
2.40
(
p
<
0.01).
Conclusion
In
adults,
strongly
an
increased
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 11, 2024
Abstract
Diet,
serving
as
a
vital
source
of
nutrients,
exerts
profound
influence
on
human
health
and
disease
progression.
Recently,
dietary
interventions
have
emerged
promising
adjunctive
treatment
strategies
not
only
for
cancer
but
also
neurodegenerative
diseases,
autoimmune
cardiovascular
metabolic
disorders.
These
demonstrated
substantial
potential
in
modulating
metabolism,
trajectory,
therapeutic
responses.
Metabolic
reprogramming
is
hallmark
malignant
progression,
deeper
understanding
this
phenomenon
tumors
its
effects
immune
regulation
significant
challenge
that
impedes
eradication.
Dietary
intake,
key
environmental
factor,
can
tumor
metabolism.
Emerging
evidence
indicates
might
affect
the
nutrient
availability
tumors,
thereby
increasing
efficacy
treatments.
However,
intricate
interplay
between
pathogenesis
other
diseases
complex.
Despite
encouraging
results,
mechanisms
underlying
diet-based
remain
largely
unexplored,
often
resulting
underutilization
management.
In
review,
we
aim
to
illuminate
various
interventions,
including
calorie
restriction,
fasting-mimicking
diet,
ketogenic
protein
restriction
high-salt
high-fat
high-fiber
aforementioned
diseases.
We
explore
multifaceted
impacts
these
encompassing
their
immunomodulatory
effects,
biological
impacts,
molecular
mechanisms.
This
review
offers
valuable
insights
into
application
therapies
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(14), P. 3204 - 3204
Published: July 19, 2023
Alzheimer's
disease
(AD)
is
a
growing
concern
for
the
aging
population
worldwide.
With
no
current
cure
or
reliable
treatments
available
AD,
prevention
an
important
and
area
of
research.
A
range
lifestyle
dietary
patterns
have
been
studied
to
identify
most
effective
preventive
changes
against
AD
related
dementia
(ADRD)
pathology.
Of
these,
are
Mediterranean,
DASH,
MIND,
ketogenic,
modified
Mediterranean-ketogenic
diets.
However,
there
discrepancies
in
reported
benefits
among
studies
examining
these
patterns.
We
herein
compile
narrative/literature
review
existing
clinical
evidence
on
association
with
ADRD
symptomology
contemplate
their
preventive/ameliorative
effects
neuropathology
various
milieus.
By
large,
plant-based
found
be
relatively
consistently
positively
correlated
preventing
reducing
odds
ADRD.
These
impacts
stem
not
only
from
direct
impact
specific
components
within
brain
but
also
indirect
through
decreasing
deleterious
risk
factors,
such
as
diabetes,
obesity,
cardiovascular
diseases.
Importantly,
other
psychosocial
factors
influence
intake,
social
connection,
which
may
directly
diet
lifestyle,
thereby
impacting
risk.
To
this
end,
prospective
research
should
include
holistic
approach,
including
considerations.
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(3), P. 412 - 412
Published: Jan. 31, 2024
Alzheimer’s
disease
(AD),
the
most
prevalent
form
of
dementia,
is
characterized
by
accumulation
amyloid-beta
(Aβ)
plaques
and
hyperphosphorylated
tau
tangles.
Currently,
(AD)
impacts
50
million
individuals,
with
projections
anticipating
an
increase
to
152
year
2050.
Despite
increasing
global
prevalence
AD,
its
underlying
pathology
remains
poorly
understood,
posing
challenges
for
early
diagnosis
treatment.
Recent
research
suggests
a
link
between
gut
dysbiosis
aggregation
Aβ,
development
proteins,
occurrence
neuroinflammation
oxidative
stress
are
associated
AD.
However,
investigations
into
gut–brain
axis
(GBA)
in
context
AD
progression
have
yielded
inconsistent
findings.
This
review
aims
enhance
our
understanding
microbial
diversity
at
species
level
role
these
pathology.
Additionally,
this
addresses
influence
confounding
elements,
including
diet,
probiotics,
prebiotics,
on
throughout
different
stages
(preclinical,
mild
cognitive
impairment
(MCI),
AD)
progression.
Advances in Nutrition,
Journal Year:
2023,
Volume and Issue:
14(4), P. 819 - 839
Published: April 17, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
characterized
by
progressive
cognitive
impairment
and
neuroinflammation.
Recent
research
has
revealed
the
crucial
role
of
gut
microbiota
microbial
metabolites
in
modulating
AD.
However,
mechanisms
which
microbiome
affect
brain
function
remain
poorly
understood.
Here,
we
review
literature
on
changes
diversity
composition
patients
with
AD
animal
models
We
also
discuss
latest
progress
understanding
pathways
from
host
or
diet
regulate
By
effects
dietary
components
function,
composition,
metabolites,
examine
potential
for
manipulation
through
intervention
to
delay
progression
Although
it
challenging
translate
our
microbiome-based
approaches
guidelines
clinical
therapies,
these
findings
provide
an
attractive
target
promoting
function.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2023,
Volume and Issue:
152, P. 105286 - 105286
Published: June 15, 2023
Oldest-old
is
the
fastest
growing
segment
of
society.
A
substantial
number
these
individuals
are
cognitively
impaired
or
demented.
Given
lack
a
cure,
attention
directed
to
lifestyle
interventions
that
could
help
alleviate
stress
in
patients,
their
families,
and
The
aim
this
review
was
identify
factors
with
important
roles
dementia
prevention
oldest-old.
Searches
were
conducted
PubMed,
EMBASE,
Scopus
Web
Science.
We
identified
27
observational
cohort
studies
met
inclusion
criteria.
Results
showed
eating
healthy
diet
plenty
fruits
vegetables,
participation
leisure
physical
activities
may
protect
against
cognitive
decline
impairment
among
oldest-old
regardless
APOE
genotype.
Combined
lifestyles
generate
multiplicative
effects
than
individual
factors.
This
first
known
systematically
examine
association
between
health
Lifestyle
for
diet,
leisure,
combination
be
beneficial
function
Interventional
warranted
strengthen
evidence.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(3)
Published: May 16, 2023
Abstract
The
ketogenic
diet
(KD)
is
a
low‐carbohydrate,
high‐fat
regime
that
protective
against
neurodegenerative
diseases.
However,
the
impact
of
KD
on
Parkinson's
disease
(PD)
and
its
mechanisms
remains
unclear.
1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine
(MPTP)‐induced
mouse
model
PD
was
fed
with
for
8
weeks.
Motor
function
dopaminergic
neurons
were
evaluated.
Inflammation
in
brain,
plasma,
colon
tissue
also
measured.
Fecal
samples
assessed
by
16S
rDNA
gene
sequencing
untargeted
metabolomics.
We
found
protected
motor
dysfunction,
neuron
loss,
inflammation
an
MPTP
PD.
revealed
administration
significantly
increased
Citrobacter
,
Desulfovibrio
Ruminococcus
decreased
Dubosiella
whereas
treatment
reversed
dysbiosis.
Meanwhile,
regulated
MPTP‐induced
histamine,
N‐acetylputrescine,
d
‐aspartic
acid,
other
metabolites.
microbiota
transplantation
using
feces
from
KD‐treated
mice
attenuated
impairment
loss
antibiotic‐pretreated
mice.
Our
current
study
demonstrates
played
neuroprotective
role
through
diet–gut
microbiota–brain
axis,
which
may
involve
brain
colon.
future
research
warranted
to
explore
explicit
anti‐inflammatory
gut–brain
axis
models
KD.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: July 20, 2024
Abstract
Previous
studies
have
shown
a
bidirectional
communication
between
human
gut
microbiota
and
the
brain,
known
as
microbiota–gut–brain
axis
(MGBA).
The
MGBA
influences
host's
nervous
system
development,
emotional
regulation,
cognitive
function
through
neurotransmitters,
immune
modulation,
metabolic
pathways.
Factors
like
diet,
lifestyle,
genetics,
environment
shape
composition
together.
Most
research
explored
how
regulates
host
physiology
its
potential
in
preventing
treating
neurological
disorders.
However,
individual
heterogeneity
of
microbiota,
strains
playing
dominant
role
diseases,
interactions
these
microbial
metabolites
with
central/peripheral
systems
still
need
exploration.
This
review
summarizes
driving
neurodevelopmental
disorders
(autism
spectrum
disorder
attention
deficit/hyperactivity
disorder),
neurodegenerative
diseases
(Alzheimer's
Parkinson's
disease),
mood
(anxiety
depression)
recent
years
discusses
current
clinical
preclinical
microbe‐based
interventions,
including
dietary
intervention,
probiotics,
prebiotics,
fecal
transplantation.
It
also
puts
forward
insufficient
on
provides
framework
for
further
Alzheimer s & Dementia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Abstract
Alzheimer's
disease
(AD)
is
a
degenerative
characterized
by
progressive
cognitive
dysfunction.
The
strong
link
between
nutrition
and
the
occurrence
progression
of
AD
pathology
has
been
well
documented.
Poor
nutritional
status
accelerates
progress
potentially
aggravating
amyloid
beta
(Aβ)
tau
deposition,
exacerbating
oxidative
stress
response,
modulating
microbiota–gut–brain
axis,
disrupting
blood–brain
barrier
function.
advanced
stage
tends
to
lead
malnutrition
due
impairments,
sensory
dysfunctions,
brain
atrophy,
behavioral
psychological
symptoms
dementia
(BPSD).
This,
in
turn,
produces
vicious
cycle
AD.
This
review
discusses
how
factors
deteriorate
each
other
from
early
terminal
stages
AD,
focusing
on
potential
different
levels
factors,
ranging
micronutrients
diet
patterns.
provides
novel
insights
into
reducing
risk
delaying
its
progression,
improving
prognosis.
Highlights
Two‐fifths
cases
worldwide
have
attributed
modifiable
factors.
Up
≈26%
community‐dwelling
patients
with
are
malnourished,
compared
7%∼76%
institutionalized
patients.
Undernutrition
effects
onset,
prognosis
through
multiple
mechanisms.
Various
supports
were
confirmed
be
protective
for
via
specific
