Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(4), P. 1114 - 1127
Published: Jan. 4, 2024
Language: Английский
Citations
18
Journal of Clinical and Translational Science, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27
Published: Jan. 22, 2025
Clinical translational neuroscience (CTN) is positioned to generate novel discoveries for advancing treatments mental health disorders, but it held back today by the siloing of bioethical considerations from critical consciousness. In this article, we suggest that and consciousness can be paired intersect with structures power within which science clinical practice are conducted. We examine barriers adoption findings in perspective, especially context current collective attention widespread disparities access outcomes services, lack representation marginalized populations relevant sectors workforce, importance knowledge draws upon multicultural perspectives. provide 10 actionable solutions confront these CTN research, as informed existing frameworks such structural competency, adaptive calibration models, community-based participatory research. By integrating considerations, believe practitioners will better benefit cutting-edge research biological social sciences than past, alert biases equipped mitigate them, poised shepherd a robust generation future therapies practitioners.
Language: Английский
Citations
1
NeuroImage, Journal Year: 2023, Volume and Issue: 277, P. 120242 - 120242
Published: June 21, 2023
The extensive use of transcranial direct current stimulation (tDCS) in experimental and clinical settings does not correspond to an in-depth understanding its underlying neurophysiological mechanisms. In previous studies, we employed integrated system Transcranial Magnetic Stimulation Electroencephalography (TMS-EEG) track the effect tDCS on cortical excitability. At rest, anodal (a-tDCS) over right Posterior Parietal Cortex (rPPC) elicits a widespread increase contrast, cathodal (c-tDCS) fails modulate excitability, being indistinguishable from sham stimulation. Here investigated whether endogenous task-induced activation during might change this pattern, improving c-tDCS effectiveness modulating Experiment 1, tested performance Visuospatial Working Memory Task (VWMT) modified Posner Cueing (mPCT), involving rPPC, could be modulated by c-tDCS. Thirty-eight participants were involved two-session experiment receiving either or tasks execution. 2, recruited sixteen novel who performed same paradigm but underwent TMS-EEG recordings pre- 10 min post- Behavioral results showed that significantly mPCT compared sham. level, reduced excitability frontoparietal network likely task Taken together, our provide evidence state dependence effectively. conceptual applicative implications are discussed.
Language: Английский
Citations
17
Brain Sciences, Journal Year: 2024, Volume and Issue: 14(3), P. 210 - 210
Published: Feb. 24, 2024
First-line treatments for post-traumatic stress disorder (PTSD) encompass a wide range of pharmacotherapies and psychotherapies. However, many patients fail to respond such interventions, highlighting the need novel approaches. Due its ability modulate cortical activity, non-invasive brain stimulation (NIBS) could represent valuable therapeutic tool. Therefore, aim this systematic review is summarize discuss existing evidence on ameliorative effects NIBS PTSD comorbid anxiety depressive symptoms. Our goal also debate effectiveness an integrated approach characterized by combination psychotherapy. This search was conducted following preferred reporting items reviews meta-analyses (PRISMA) guidelines in PubMed, PsycINFO, PsycARTICLES, PSYINDEX, MEDLINE, ERIC databases. Overall, 31 studies met eligibility criteria, yielding total 26 clinical trials employing transcranial magnetic (TMS) 5 making use direct-current (tDCS). From these studies, it emerged that consistently reduced overall symptoms' severity as well Moreover, we speculate combining with prolonged exposure or cognitive processing therapy might promising ameliorating subjects' conditions.
Language: Английский
Citations
8
Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15
Published: Feb. 20, 2024
Schizophrenia is a severe, chronic mental disorder that profoundly impacts patients’ everyday lives. The illness’s core features include positive and negative symptoms cognitive impairments. In particular, deficits in the social cognition domain showed tighter connection to functioning than other symptoms. Social remediation interventions have been developed, providing heterogeneous results considering possibility of generalizing acquired improvements daily activities. this pilot randomized controlled trial, we investigated feasibility combining fifteen training sessions with non-invasive brain stimulation boost effectiveness two interventions. We delivered intermittent theta burst (iTBS) over left dorsolateral prefrontal cortex (DLPFC). Twenty-one patients were into four groups, varying for assigned condition (real vs. sham iTBS) type intervention (training no training). Clinical tests administered at five time points, i.e., before after treatment, three follow-ups one, three, six months treatments’ end. Preliminary data show trend improving competence managing emotion participants performing training. Conversely, differences found pre post-treatment scores recognition, theory mind, attribution intentions scores. iTBS did not induce additional effects on individuals’ performance. methodological approach’s novelty limitations present study are discussed.
Language: Английский
Citations
6
Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18
Published: March 6, 2024
Objective The aim of the current study was to provide a comprehensive picture tACS-related research in last decade through bibliometric approach order systematically analyze status and cutting-edge trends this field. Methods Articles review articles related tACS from 2013 2022 were searched on Web Science platform. A analysis authors, journals, countries, institutions, references, keywords performed using CiteSpace (6.2.R2), VOSviewer (1.6.19), Scimago Graphica (1.0.30), Bibliometrix (4.2.2). Results total 602 papers included. There an overall increase annual relevant publications decade. most contributing author Christoph S. Herrmann. Brain Stimulation prolific journal. countries institutions Germany Harvard University, respectively. Conclusion findings reveal development prospects future directions valuable references for researchers In recent years, “gamma,” “transcranial direct simulation,” “Alzheimer’s disease” that have erupted, as well many cited outbreak, provided certain clues mining prefaces. This will act guide determining path research.
Language: Английский
Citations
4
Psychiatry and Clinical Neurosciences, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Borderline personality disorder (BPD) patients show negative emotional reactions to both excluding and including social scenarios, with levels normalizing only during extreme inclusion. Prior research among healthy individuals highlights the right ventrolateral prefrontal cortex (rVLPFC) role in regulating responses exclusion, since transcranial direct current stimulation (tDCS) of rVLPFC decreases rejection-related emotions following exclusion. This pilot study investigated whether, BPD patients, tDCS over reduces not after exclusion but also fair Forty randomly received either real or sham on before participating Cyberball paradigm, which involved phases inclusion, over-inclusion. Participants self-reported their level each phase. Transcranial reduced Specifically, those Real group exhibited comparable over-including unlike Sham who experienced heightened inclusion compared patients' tendency feel rejected fairly scenarios. These findings confirm involvement regulation highlight a therapeutic potential for moderating BPD's typical supports application treatment, providing new insights into neuromodulatory interventions that can aid better regulate varying
Language: Английский
Citations
0
Pain, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Abstract Transcranial focused ultrasound (tFUS) is an emerging noninvasive neuromodulation technology that has shown great potential in pain modulation. This review systematically elucidates the multilevel biological mechanisms of tFUS neuromodulation, from network-wide effects to cellular and molecular processes, as well broader systemic influences. Preliminary animal model studies have revealed tFUS's ability improve behavioral indicators modulate neural circuit activity under pathological conditions. A small number clinical also suggest may certain benefits improving symptom experience emotional state chronic patients. However, current research generally limitations such sample sizes short follow-up periods. More high-quality are needed verify long-term safety treatment. Overcoming these advancing large-scale translational will help fully exploit application precision medicine provide new treatment options for relief.
Language: Английский
Citations
0
Brain Sciences, Journal Year: 2023, Volume and Issue: 13(4), P. 698 - 698
Published: April 21, 2023
Gambling disorder (GD) is a behavioral addiction that severely impacts individuals’ functioning, leading to high socioeconomic costs. Non-invasive brain stimulation (NiBS) has received attention for treating psychiatric and neurological conditions in recent decades, but there no recommendation its use GD. Therefore, this study aimed systematically review analyze the available literature determine effectiveness of NiBS Following PRISMA guidelines, we screened four electronic databases up July 2022 selected relevant English-written original articles. We included ten papers systematic seven meta-analysis. As only two studies employed sham-controlled design, pre–post standardized mean change (SMCC) was computed as effect size real stimulation. The results showed significant reducing craving scores (SMCC = −0.69; 95% CI [−1.2, −0.2], p 0.010). Moreover, considering GD’s frequent comorbidity with mood disorders, ran an exploratory analysis effects on depressive symptoms, which decreases post-treatment −0.71; [−1.1, −0.3], < 0.001). These provide initial evidence developing feasible therapy GD symptoms further comprehensive research needed validate these findings. limitations are critically discussed.
Language: Английский
Citations
10
Brain Sciences, Journal Year: 2023, Volume and Issue: 13(12), P. 1665 - 1665
Published: Nov. 30, 2023
(1) Background: Psychological interventions are effective in alleviating neuropsychiatric symptoms, though results can vary between patients. Repetitive transcranial magnetic stimulation (rTMS) has been proven to improve clinical symptoms and cognition. It remains unclear whether rTMS augment the efficacy of psychological interventions. (2) Methods: We examined effects combined with on clinical, functional, cognitive outcomes from randomized controlled trials conducted healthy populations. searched PubMed, EMBASE, Cochrane Library, PsycINFO databases up April 2023. (3) Results: Twenty-seven studies were ultimately included. Compared sham interventions, active significantly improved overall (k = 16, SMD 0.31, CIs 0.08 0.54, p < 0.01). found that 10 or more sessions behavioural therapy 3, 0.21, 0.05 0.36, Z 2.49, RTMS training (CT) cognition compared CT 13, 0.28, 0.15 0.42, 0.01), a significant effect global 11, 0.45, 0.21 0.68, but not other domains. (4) Conclusion: The current provide preliminary support for augmentation across diverse Future required confirm these specific
Language: Английский
Citations
10