High-amplitude network co-fluctuations linked to variation in hormone concentrations over menstrual cycle

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: July 29, 2021

Many studies have shown that the human endocrine system modulates brain function, reporting associations between fluctuations in hormone concentrations and both activity connectivity. However, how hormonal impact fast changes network structure over short timescales remains unknown. Here, we leverage “edge time series” analysis to investigate relationship high-amplitude states quotidian variation sex steroid gonadotropic hormones a single individual sampled course of two states, across natural menstrual cycle under regimen. We find frequency are associated with follicle-stimulating luteinizing hormone, but not estradiol progesterone. Nevertheless, show scan-to-scan co-fluctuation patterns expressed during robustly linked concentration all four hormones, positing network-level target control. conclude by speculating on role shaping ongoing dynamics.

Language: Английский

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Functional gradients of the medial parietal cortex in a healthy cohort with family history of sporadic Alzheimer’s disease

Alzheimer s Research & Therapy, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 19, 2023

Abstract Background The medial parietal cortex is an early site of pathological protein deposition in Alzheimer’s disease (AD). Previous studies have identified different subregions within this area; however, these are often heterogeneous and disregard individual differences or subtle alterations the underlying functional architecture. To address limitation, here we measured continuous connectivity gradients assessed their relationship with cerebrospinal fluid (CSF) biomarkers, ApoE ε4 carriership memory asymptomatic individuals at risk to develop AD. Methods Two hundred sixty-three cognitively normal participants a family history sporadic AD who underwent resting-state task-based MRI using encoding retrieval tasks were included from PREVENT-AD cohort. A novel method for characterizing spatially patterns was applied estimate during conditions. This resulted set nine parameters that described appearance gradient across spatial directions. We performed correlation analyses assess whether associated CSF biomarkers phosphorylated tau 181 (p-tau), total (t-tau), amyloid-ß 1-42 (Aß). Then, compared between carriers noncarriers, evaluated memory. Results Alterations involving superior part cortex, which connected regions default mode network, higher p-tau, t-tau levels as well lower Aß/p-tau condition ( p < 0.01). Similar found non-carriers 0.003). In contrast, immediate scores changes middle inferior temporal posterior regions, task = 0.001). No results when conventional measures. Conclusions Functional carriership, cohort AD, suggesting sensitive stages.

Language: Английский

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Sophisticated perspective-takers are distinctive: neural idiosyncrasy of functional connectivity in the mentalizing network

iScience, Journal Year: 2024, Volume and Issue: 27(12), P. 111472 - 111472

Published: Nov. 23, 2024

Naive perspective-takers often perceive the social world in a simplistic and uniform way, whereas sophisticated ones recognize diversity complexity of others' minds. This commonly accepted distinction points to possibility greater inter-individual variability mentalizing for than naive perspective-takers, difference previously overlooked research. In current study, participants were asked watch mentalizing-related movie their neural responses, interpretations characters' mental states, eye-gaze trajectories recorded. The results provide robust converging evidence that connectomic features within network, trajectories, states exhibit among compared ones, supporting are more distinctive while similar. These findings deepen our understanding by highlighting idiosyncrasy homogeneity collaboration behavioral manifestations across varying levels perspective-taking sophistication.

Language: Английский

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Dynamic and stationary brain connectivity during movie watching as revealed by functional MRI

Brain Structure and Function, Journal Year: 2022, Volume and Issue: 227(7), P. 2299 - 2312

Published: June 29, 2022

Language: Английский

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Dynamic hippocampal-cortical interactions during event boundaries support retention of complex narrative events

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Oct. 24, 2022

Abstract According to most memory theories, encoding involves continuous communication between the hippocampus and neocortex leaving temporal dynamics of hippocampal-neocortical interactions often overlooked. Recent work has shown that we perceive complex events in our lives as dynamic, with relatively distinct starting stopping points known event boundaries. Event boundaries may be important for memory, they are associated increased activity hippocampus, extended neocortical regions (the posterior cingulate cortex, lateral parietal parahippocampal cortex). Our objective was determine how functional connectivity during naturalistic (movies) related subsequent retrieval retention those events. Participants encoded two 16-minute cartoon movies fMRI scanning. After encoding, participants freely recalled one immediately, other after a 2-day delay. We quantified (FC) at time windows around each onset, middle, offset, compared these FC measures recall. These analyses revealed higher medial network (PMN) an event’s offset whether subsequently recalled. In contrast, mid-event PMN poorer memory. Furthermore, hippocampal-PMN predicted not only were retained but also degree which could detail data demonstrate relationship interaction is more dynamic than suggested by converge recent modeling suggesting optimal encoding.

Language: Английский

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Emotional states as distinct configurations of functional brain networks

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(9), P. 5727 - 5739

Published: Dec. 1, 2022

Abstract The conceptualization of emotional states as patterns interactions between large-scale brain networks has recently gained support. Yet, few studies have directly examined the brain’s network structure during experiences. Here, we investigated functional organization experiences sadness, amusement, and neutral elicited by movies, in addition to a resting-state. We tested effects experienced emotion on individual variability connectome. Next, for each state, defined community quantified its segregation integration. found that relative was associated with higher modular integration increased connectivity cognitive control networks: salience fronto-parietal networks. Moreover, both connectome report, similarity individuals dependent sex. Our results suggest experience is linked reconfiguration whole-brain distributed, not emotion-specific, topological carries information about subjective experience.

Language: Английский

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System-level high-amplitude co-fluctuations

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 28, 2022

Edge time series decompose interregional correlations (functional connectivity; FC) into their time-varying contributions. Previous studies have revealed that brief, high-amplitude, and globally-defined “events” contribute disproportionately to the time-averaged FC pattern. This whole-brain view prioritizes systems occupy vast neocortical territory, possibly obscuring extremely high-amplitude co-fluctuations are localized smaller brain systems. Here, we investigate local events detected at system level, assessing independent contributions global characterizing repertoire during resting-state movie-watching scans. We find that, as expected, more likely occur when large exhibit events. Next, study co-fluctuation patterns coincide with events–i.e. locally based on behavior of individual although each exhibits a distinct pattern is dissimilar from those associated events, can nonetheless be grouped two broad categories, corresponding sensorimotor attention and, separately, association then system-level movie-watching, discovering timing in decouple, yielding reductions amplitude. show by associating edge its most similar system-averaged series, recover overlapping community structure, obviating need for applying clustering algorithms high-dimensional series. Finally, focus cortical responses subcortical areas cerebellum. these structures spatially distributed co-fluctuations, centered prefrontal somatosensory Collectively, findings presented here help clarify relative small well behavior.

Language: Английский

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Integrating Region- and Network-level Contributions to Episodic Recollection Using Multilevel Structural Equation Modeling

Journal of Cognitive Neuroscience, Journal Year: 2022, Volume and Issue: 34(12), P. 2341 - 2359

Published: Jan. 1, 2022

Abstract The brain is composed of networks interacting regions that support higher-order cognition. Among these, a core network has been associated with recollection and other forms episodic construction. Past research focused largely on the roles individual in or their mutual engagement as part an integrated network. However, relationship between these region- network-level contributions remains poorly understood. Here, we applied multilevel structural equation modeling to examine functional organization posterior medial (PM) its memory outcomes. We evaluated two aspects heterogeneity PM network: first, into subnetworks, second, presence regionally specific while accounting for effects. Our results suggest ventral dorsal subnetwork making unique contribution recollection, especially spatial information, memory-related activity well accounted by These findings highlight importance considering functions within context affiliated networks.

Language: Английский

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Dynamic and stationary brain connectivity during movie watching as revealed by functional MRI

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2021, Volume and Issue: unknown

Published: Sept. 16, 2021

Abstract Spatially remote brain regions show synchronized activity as typically revealed by correlated functional MRI (fMRI) signals. An emerging line of research has focused on the temporal fluctuations connectivity; however, its relationships with stationary connectivity have not been clearly illustrated. We examined dynamic and when participants watched four different movie clips. calculated point-by-point multiplication between two regional time series to estimate time-resolved connectivity, estimated inter-individual consistency series. Widespread consistent was observed for each clip, which also showed differences For example, a cartoon Wall-E, more posterior cingulate cortex supramarginal gyrus, while court drama A Few Good Men, auditory temporoparietal junction, might suggest involvement specific processing contents. In contrast, measured correlations highly similar among clips, fewer statistically significant differences. The patterns could be used classify clips higher accuracy than activity. These results support significance in reflecting changes, provide functionally relevant information connectivity.

Language: Английский

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Synchronous high-amplitude co-fluctuations of functional brain networks during movie-watching

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: July 4, 2022

Recent studies have shown that functional connectivity can be decomposed into its exact framewise contributions, revealing short-lived, infrequent, and high-amplitude time points referred to as “events.” Events contribute disproportionately the time-averaged pattern, improve identifiability brain-behavior associations, differences in their expression been linked endogenous hormonal fluctuations autism. Here, we explore characteristics of events while subjects watch movies. Using two independently-acquired imaging datasets which participants passively watched movies, find synchronize across individuals based on level synchronization, categorized three distinct classes: those at boundaries between during do not all. We boundary events, compared other categories, exhibit greater amplitude, co-fluctuation patterns, temporal propagation. show underlying is a specific mode involving activation control salience systems alongside deactivation visual systems. movie, hand, display pattern time-locked movie stimulus. Finally, found subjects’ time-varying brain networks are most similar one another these synchronous events.

Language: Английский

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