A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats DOI Creative Commons
Douglas Senna Engelke, Xu O. Zhang, John J. O’Malley

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 4, 2021

Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat test in rats, we identified subpopulation of neurons anterior portion paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) are preferentially recruited during conflict. Inactivation aPVTCRF biases animal's response toward food, whereas activation these cells recapitulates food-seeking suppression observed project densely to accumbens (NAc), activity pathway reduces food increases avoidance. In addition, ventromedial hypothalamus (VMH) as critical input neurons, demonstrated VMH-aPVT mediate defensive behaviors exclusively Together, our findings describe hypothalamic-thalamostriatal circuit suppresses reward-seeking behavior under competing demands threats.

Language: Английский

Divergent medial amygdala projections regulate approach–avoidance conflict behavior DOI

Samara Miller,

Daniele Marcotulli,

Angela Shen

et al.

Nature Neuroscience, Journal Year: 2019, Volume and Issue: 22(4), P. 565 - 575

Published: Feb. 25, 2019

Language: Английский

Citations

108
The Neural Basis of Escape Behavior in Vertebrates DOI
Tiago Branco, Peter Redgrave

Annual Review of Neuroscience, Journal Year: 2020, Volume and Issue: 43(1), P. 417 - 439

Published: April 7, 2020

Escape is one of the most studied animal behaviors, and there a rich normative theory that links threat properties to evasive actions their timing. The behavioral principles escape are evolutionarily conserved rely on elementary computational steps such as classifying sensory stimuli executing appropriate movements. These common building blocks general adaptive behaviors. Here we consider challenges required for behaviors be implemented, discuss possible algorithmic solutions, review some underlying neural circuits mechanisms. We outline shared can implemented by ancient systems generate behavior, which cortical encephalization has been added allow increased sophistication flexibility in responding threat.

Language: Английский

Citations

104
A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia DOI
Na Qu, Yanlin He, Chunmei Wang

et al.

Molecular Psychiatry, Journal Year: 2019, Volume and Issue: 25(5), P. 1006 - 1021

Published: Sept. 5, 2019

Language: Английский

Citations

98
Reciprocal control of obesity and anxiety–depressive disorder via a GABA and serotonin neural circuit DOI Creative Commons
Guobin Xia, Yong Han, Fantao Meng

et al.

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 26(7), P. 2837 - 2853

Published: March 26, 2021

Abstract The high comorbidity between obesity and mental disorders, such as depression anxiety, often exacerbates metabolic neurological symptoms significantly. However, neural mechanisms that underlie reciprocal control of feeding states are largely elusive. Here we report melanocortin 4 receptor (MC4R) neurons located in the dorsal bed nucleus stria terminus (dBNST) engage regulation mentally associated weight gain by receiving GABAergic projections from hypothalamic AgRP onto α5-containing GABA A receptors serotonergic afferents 5-HT 3 receptors. Chronic treatment with a high-fat diet (HFD) significantly blunts hyperexcitability response to not only hunger but also anxiety depression-like stimuli. Such HFD-mediated desensitization reduces outputs downstream MC4R dBNST neurons, resulting severe dysregulation. Genetic enhancement R-α5 or suppression R within abolishes HFD-induced robustly body food intake. To further translational insights, revealed combined zonisamide (enhancing signaling) granisetron (a selective antagonist) alleviates dysfunction yields robust reversal diet-induced reducing total calorie intake altering preference towards healthy low-fat diet. Our results unveil mechanism for appetite states, which culminates novel zonisamide-granisetron cocktail therapy potential tackling psychosis-obesity comorbidity.

Language: Английский

Citations

93
A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats DOI Creative Commons
Douglas Senna Engelke, Xu O. Zhang, John J. O’Malley

et al.

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 4, 2021

Survival depends on a balance between seeking rewards and avoiding potential threats, but the neural circuits that regulate this motivational conflict remain largely unknown. Using an approach-food vs. avoid-predator threat test in rats, we identified subpopulation of neurons anterior portion paraventricular thalamic nucleus (aPVT) which express corticotrophin-releasing factor (CRF) are preferentially recruited during conflict. Inactivation aPVTCRF biases animal's response toward food, whereas activation these cells recapitulates food-seeking suppression observed project densely to accumbens (NAc), activity pathway reduces food increases avoidance. In addition, ventromedial hypothalamus (VMH) as critical input neurons, demonstrated VMH-aPVT mediate defensive behaviors exclusively Together, our findings describe hypothalamic-thalamostriatal circuit suppresses reward-seeking behavior under competing demands threats.

Language: Английский

Citations

92