Coding of whisker motion across the mouse face DOI Creative Commons
Kyle S. Severson, Duo Xu, Hongdian Yang

et al.

eLife, Journal Year: 2019, Volume and Issue: 8

Published: Feb. 28, 2019

Haptic perception synthesizes touch with proprioception, the sense of body position. Humans and mice alike experience rich active face. Because most facial muscles lack proprioceptor endings, sensory basis proprioception remains unsolved. Facial may instead rely on mechanoreceptors that encode both self-motion. In rodents, whisker provide a signal informs brain about Whisking involves coordinated orofacial movements, so innervating regions other than whiskers could also information whisking. To define all sources whisking available to brain, we recorded spikes from diverse parts Whisker motion was encoded best by mechanoreceptors, but those pad hairy skin supraorbital vibrissae. Redundant self-motion responses stable proprioceptive despite mechanical perturbations during touch.

Language: Английский

Sensorimotor Integration and Amplification of Reflexive Whisking by Well-Timed Spiking in the Cerebellar Corticonuclear Circuit DOI Creative Commons
Spencer T. Brown, Indira M. Raman

Neuron, Journal Year: 2018, Volume and Issue: 99(3), P. 564 - 575.e2

Published: July 14, 2018

Language: Английский

Citations

76
A machine-vision approach for automated pain measurement at millisecond timescales DOI Creative Commons
Jessica Jones, William Foster, Colin R. Twomey

et al.

eLife, Journal Year: 2020, Volume and Issue: 9

Published: Aug. 6, 2020

Objective and automatic measurement of pain in mice remains a barrier for discovery neuroscience. Here, we capture paw kinematics during behavior with high-speed videography automated tracking machine deep learning approaches. Our statistical software platform, PAWS (Pain Assessment at Withdrawal Speeds), uses univariate projection position over time to automatically quantify seven behavioral features that are combined into single, score. Automated reveals behaviorally divergent mouse strain displays hypersensitivity mechanical stimuli. To demonstrate the efficacy detecting spinally versus centrally mediated responses, chemogenetically activated nociceptive neurons amygdala, which further separated pain-related resulting Taken together, this quantification approach will increase objectivity collecting rigorous data, it is compatible other neural circuit dissection tools determining state.

Language: Английский

Citations

65
Slip-Based Coding of Local Shape and Texture in Mouse S1 DOI Creative Commons
Brian Isett, Sierra H. Feasel,

Monet A. Lane

et al.

Neuron, Journal Year: 2018, Volume and Issue: 97(2), P. 418 - 433.e5

Published: Jan. 1, 2018

Language: Английский

Citations

64
Myomatrix arrays for high-definition muscle recording DOI Creative Commons
Bryce Chung, Muneeb Zia, Kyle Thomas

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: July 12, 2023

Neurons coordinate their activity to produce an astonishing variety of motor behaviors. Our present understanding control has grown rapidly thanks new methods for recording and analyzing populations many individual neurons over time. In contrast, current the nervous system's actual output - activation muscle fibers by typically cannot detect electrical events produced during natural behaviors scale poorly across species groups. Here we a novel class electrode devices ('Myomatrix arrays') that record at unprecedented resolution muscles High-density, flexible arrays allow stable recordings from activated single neuron, called 'motor unit,' in species, including mice, rats, primates, songbirds, frogs, insects. This technology therefore allows be monitored detail complex morphologies. We anticipate this will rapid advances neural behavior identifying pathologies system.

Language: Английский

Citations

17
Of mice and monkeys: Somatosensory processing in two prominent animal models DOI Creative Commons
Daniel H. O’Connor, Leah Krubitzer, Sliman J. Bensmaı̈a

et al.

Progress in Neurobiology, Journal Year: 2021, Volume and Issue: 201, P. 102008 - 102008

Published: Feb. 15, 2021

Our understanding of the neural basis somatosensation is based largely on studies whisker system mice and rats hands macaque monkeys. Results across these animal models are often interpreted as providing direct insight into human somatosensation. Work systems has proceeded in parallel, capitalizing strengths each model, but rarely been considered a whole. This lack integration promotes piecemeal Here, we examine functions morphologies whiskers rats, monkeys, somatosensory neuraxes three species. We then discuss how information encoded their respective nervous systems, highlighting similarities differences. reflect limitations consider key gaps our

Language: Английский

Citations

34
What the Whiskers Tell the Brain DOI Creative Commons
Dario Campagner, Mathew H. Evans, Michaela S. E. Loft

et al.

Neuroscience, Journal Year: 2017, Volume and Issue: 368, P. 95 - 108

Published: Aug. 24, 2017

A fundamental question in the investigation of any sensory system is what physical signals drive its neurons during natural behavior. Surprisingly, whisker system, it only recently that answers to this have emerged. Here, we review key developments, focussing mainly on first stage ascending pathway – primary afferents (PWAs). We consider a biomechanical framework, which describes mechanical forces acting whiskers active sensation. then discuss technical progress has allowed such variables be estimated awake, behaving animals. past electrophysiological evidence concerning how PWAs function and reinterpret within framework. Finally, recent studies animals compare results related cortex. argue understanding 'what tell brain' sheds valuable light computational functions downstream neural circuits, particular, barrel

Language: Английский

Citations

43
A spiking and adapting tactile sensor for neuromorphic applications DOI Creative Commons
Tom Birkoben, Henning Winterfeld, Simon Fichtner

et al.

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Oct. 14, 2020

Abstract The ongoing research on and development of increasingly intelligent artificial systems propels the need for bio inspired pressure sensitive spiking circuits. Here we present an adapting tactile sensor, based a neuronal model piezoelectric field-effect transistor (PiezoFET). sensor device consists metal-oxide semiconductor comprising aluminium-scandium-nitride (Al x Sc 1−x N) layer inside gate stack. so augmented is to mechanical stress. In combination with analogue circuit, this unit capable encoding quantity into series spikes adaptation output frequency. This allows broad application in context robotic neuromorphic systems, since it enables said receive information from surrounding environment provide encoded spike trains hardware. We numerical experimental results sensor.

Language: Английский

Citations

37
Behavioral and Neural Bases of Tactile Shape Discrimination Learning in Head-Fixed Mice DOI Creative Commons
Jinho Kim, Andrew Erskine, Jonathan Andrew Cheung

et al.

Neuron, Journal Year: 2020, Volume and Issue: 108(5), P. 953 - 967.e8

Published: Sept. 30, 2020

Language: Английский

Citations

34
Transformation of primary sensory cortical representations from layer 4 to layer 2 DOI Creative Commons
Bettina Voelcker, Ravi Pancholi, Simon Peron

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 19, 2022

Abstract Sensory input arrives from thalamus in cortical layer (L) 4, which outputs predominantly to superficial layers. L4 L2 thus constitutes one of the earliest feedforward networks. Despite extensive study, transformation performed by this network remains poorly understood. We use two-photon calcium imaging record neural activity L2-4 primary vibrissal somatosensory cortex (vS1) as mice perform an object localization task with two whiskers. Touch responses sparsen and become more reliable L2, nearly half touch response confined ~1 % excitatory neurons. These highly responsive neurons have broad receptive fields can accurately decode stimulus features. They participate disproportionately ensembles, small subnetworks elevated pairwise correlations. Thus, transitions distributed probabilistic coding sparse robust ensemble-based coding, resulting efficient accurate representations.

Language: Английский

Citations

21
Feedforward and disinhibitory circuits differentially control activity of cortical somatostatin interneurons during behavioral state transitions DOI Creative Commons

Marcel de Brito Van Velze,

Dhanasak Dhanasobhon,

Marie Martinez

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(5), P. 114197 - 114197

Published: May 1, 2024

Interneurons (INs), specifically those in disinhibitory circuits like somatostatin (SST) and vasoactive intestinal peptide (VIP)-INs, are strongly modulated by the behavioral context. Yet, mechanisms which these INs recruited during active states whether their activity is consistent across sensory cortices remain unclear. We now report that mice, locomotor recruits SST-INs primary somatosensory (S1) but not visual (V1) cortex. This diverse engagement of cannot be explained differences VIP-IN function absent presence input, suggesting involvement feedforward pathways. Accordingly, inactivating thalamus, decreasing activity, significantly reduces modulation locomotion. Model simulations suggest can varying ratios VIP- thalamus-driven activity. By integrating with neuromodulation, anticipated to crucial for adapting processing states.

Language: Английский

Citations

4