The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions DOI Creative Commons
Enny H. van Beest,

Mohammed A.O. Abdelwahab,

J. Leonie Cazemier

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(9), P. 110753 - 110753

Published: Aug. 23, 2024

Highlights•The direct and indirect pathways have antagonistic effects on perceptual decisions•Direct pathway stimulation increases neuronal activity in the dorsal cortex•The striatum influences cortical representations of working memoriesSummaryThe striatum, main input nucleus basal ganglia, receives topographically organized from cortex gives rise to output pathways, which ganglia directed cortex. We optogenetically stimulated a visual memory task mice that responded by licking. Unilateral increased probability lick responses toward contralateral, non-stimulated side globally. In contrast, decreased hemisphere. Moreover, enhanced neural representation contralateral stimulus during delay task, whereas had opposite effect. Our results demonstrate how these two influence decisions modify cortex.Graphical abstract

Language: Английский

Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior DOI Creative Commons
Victoria L. Corbit, Sean C. Piantadosi, Jesse Wood

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(1), P. 115181 - 115181

Published: Jan. 1, 2025

Language: Английский

Citations

0
Entrainment of visuomotor responses to target speed during interception DOI
Mario Treviño, Inmaculada Márquez

Neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Cardiac Heterogeneity Prediction by Cardio-Neural Network Simulation DOI
Asif Mehmood,

Ayesha Ilyas,

H. Ilyas

et al.

Neuroinformatics, Journal Year: 2025, Volume and Issue: 23(2)

Published: Feb. 1, 2025

Language: Английский

Citations

0
Optogenetics and chemogenetics: key tools for modulating neural circuits in rodent models of depression DOI Creative Commons
Shaowei Li, Jianying Zhang, Jiehui Li

et al.

Frontiers in Neural Circuits, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 25, 2025

Optogenetics and chemogenetics are emerging neuromodulation techniques that have attracted significant attention in recent years. These enable the precise control of specific neuronal types neural circuits, allowing researchers to investigate cellular mechanisms underlying depression. The advancement these has significantly contributed understanding circuits involved depression; when combined with other technologies, they provide novel therapeutic targets diagnostic tools for clinical treatment Additionally, provided theoretical support development antidepressants. This review primarily focuses on application optogenetics several brain regions closely associated depressive-like behaviors rodent models, such as ventral tegmental area, nucleus accumbens, prefrontal cortex, hippocampus, dorsal raphe nucleus, lateral habenula discusses potential challenges future research. Furthermore, this pose research describes current state sonogenetics odourgenetics developed based chemogenetics. Specifically, study aimed reliable insights directions role depressive models.

Language: Английский

Citations

0
Multi-Scale Light-Sheet Fluorescence Microscopy for Fast Whole Brain Imaging DOI Creative Commons
Zhouzhou Zhang, Xiao Yao, Xinxin Yin

et al.

Frontiers in Neuroanatomy, Journal Year: 2021, Volume and Issue: 15

Published: Sept. 24, 2021

Whole-brain imaging has become an increasingly important approach to investigate neural structures, such as somata distribution, dendritic morphology, and axonal projection patterns. Different structures require whole-brain at different resolutions. Thus, it is highly desirable perform multiple scales. Imaging a complete mammalian brain synaptic resolution especially challenging, requires continuous from days weeks because of the large number voxels sample, difficult acquire constant quality light scattering during in toto imaging. Here, we reveal that light-sheet microscopy unique advantage over wide-field multi-scale its decoupling illumination detection. Based on this observation, have developed microscope combines tiling light-sheet, automatic zooming, periodic sectioning, tissue expansion achieve brain-wide cellular (3 μm × 3 8 μm) sub-micron (0.3 0.3 1 spatial rapidly (all within few hours). We demonstrated strength system by testing using mouse brains prepared clearing approaches. were able track electrode tracks well projections trace full morphology single medial prefrontal cortex (mPFC) neurons remarkable diversity long-range projections.

Language: Английский

Citations

25
Intrinsic Brain Activity Alterations in Patients With Mild Cognitive Impairment-to-Normal Reversion: A Resting-State Functional Magnetic Resonance Imaging Study From Voxel to Whole-Brain Level DOI Creative Commons
Qili Hu, Qianqian Wang, Yunfei Li

et al.

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 13

Published: Jan. 17, 2022

Mild cognitive impairment (MCI) reversion refers to patients with MCI who revert from a normal state. Exploring the underlying neuromechanism of reverters may contribute providing new insights into pathogenesis Alzheimer’s disease and developing therapeutic interventions. Information on healthy controls (HCs) was collected Disease Neuroimaging Initiative database. We redefined as whose logical memory scores changed levels using criteria. explored intrinsic brain activity alterations in voxel, regional, whole-brain by comparing resting-state functional magnetic resonance imaging metrics amplitude low-frequency fluctuation (ALFF), fractional (fALFF), percent (PerAF), regional homogeneity (ReHo), degree centrality (DC) between HCs. Finally, partial correlation analyses were conducted scale regions, revealing significant group differences. Thirty-two database identified reverters. Thirty-seven age-, sex-, education-matched individuals also enrolled. At voxel level, compared HCs, had increased ALFF, fALFF, PerAF frontal gyrus (including bilateral orbital inferior left middle gyrus), fusiform gyrus, decreased ALFF fALFF right cerebellum. Regarding levels, showed ReHo median cingulate paracingulate gyri; DC temporal medial superior frontal; cerebellum insular relative Furthermore, correlations found performance neuroimaging changes. These findings suggest that show changes potentially related MCI. results enhance our understanding further exploration disease.

Language: Английский

Citations

16
Neuromodulation and Neurophysiology on the Timescale of Learning and Decision-Making DOI Open Access
Cooper D. Grossman, Jeremiah Y. Cohen

Annual Review of Neuroscience, Journal Year: 2022, Volume and Issue: 45(1), P. 317 - 337

Published: April 1, 2022

Nervous systems evolved to effectively navigate the dynamics of environment achieve their goals. One framework used study this fundamental problem arose in learning and decision-making. In framework, demands effective behavior require slow dynamics-on scale seconds minutes-of networks neurons. Here, we review phenomena mechanisms involved. Using vignettes from a few species areas nervous system, view neuromodulators as key substrates for temporal scaling neuronal dynamics.

Language: Английский

Citations

15
Lateralization of short-term memory in the frontal cortex DOI Creative Commons
Xinxin Yin, Yu Wang,

Jiejue Li

et al.

Cell Reports, Journal Year: 2022, Volume and Issue: 40(7), P. 111190 - 111190

Published: Aug. 1, 2022

Despite essentially symmetric structures in mammalian brains, the left and right hemispheres do not contribute equally to certain cognitive functions. How both interact cause this asymmetry remains unclear. Here, we study question anterior lateral motor cortex (ALM) of mice performing five versions a tactile-based decision-making task with short-term memory (STM) component. Unilateral inhibition ALM produces variable behavioral deficits across tasks, left, right, or ALMs playing critical roles STM. Neural activity its encoding capability are similar hemispheres, despite that only one hemisphere dominates behavior. Inhibition dominant disrupts non-dominant ALM, but vice versa. Variable predicted by influence on contralateral sessions, mice, tasks. Together, these results reveal asymmetrically, leading their differential contributions

Language: Английский

Citations

15
The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior DOI Creative Commons
Jing Liu, Dechen Liu,

Xiaotian Pu

et al.

Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 39(10), P. 1544 - 1560

Published: May 31, 2023

The secondary motor cortex (M2) encodes choice-related information and plays an important role in cue-guided actions. M2 neurons innervate the dorsal striatum (DS), which also contributes to decision-making behavior, yet how modulates signals DS influence perceptual is unclear. Using mice performing a visual Go/No-Go task, we showed that inactivating projections impaired performance by increasing false alarm (FA) rate reward-irrelevant No-Go stimulus. choice signal of correlated with behavioral performance, inactivation projecting reduced DS. By measuring manipulating responses direct or indirect pathway striatal defined inputs, found exhibited shorter response latency stimulus, their early increased FA rate. These results demonstrate M2-to-DS crucial for suppressing inappropriate decision behavior.

Language: Английский

Citations

6
Behavioral measurements of motor readiness in mice DOI Creative Commons
Elise N. Mangin, Jian Chen,

Lin Jing

et al.

Current Biology, Journal Year: 2023, Volume and Issue: 33(17), P. 3610 - 3624.e4

Published: Aug. 14, 2023

Motor planning facilitates rapid and precise execution of volitional movements. Although motor has been classically studied in humans monkeys, the mouse become an increasingly popular model system to study neural mechanisms planning. It remains yet untested whether mice primates share common behavioral features We combined videography a delayed response task paradigm autonomous measure non-body-restrained mice. resulted both reaction time (RT) savings increased movement accuracy, replicating classic effects primates. found that was reflected task-relevant body features. Both specific actions prepared degree readiness could be read out online during The readout further revealed evidence simultaneous preparation for multiple under uncertain conditions. These results validate as planning, demonstrate feature movements powerful real-time readiness, offer can parallel process permits selection actions.

Language: Английский

Citations

5