Research progress of DNA methylation in the diagnosis and treatment of thyroid carcinoma

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 152, P. 114426 - 114426

Published: March 9, 2025

Thyroid cancer is the most prevalent endocrine malignancy, and its timely accurate diagnostic prognostic assessments are crucial for enhancing patient survival rates. As an important epigenetic modification, DNA methylation plays a key role in regulation of gene expression tumorigenesis. Recent studies increasingly indicate that abnormal patterns closely associated with onset progression thyroid cancer. This review discusses diagnosing adenocarcinoma, impact on prognosis, potential utility immunotherapy. Additionally, it explores prospect using as biomarker highlights significant personalized treatment article aims to serve resource future research clinical applications advance diagnosis

Language: Английский

Harnessing transposable elements for plant functional genomics and genome engineering

Trends in Plant Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Transposable elements (TEs) constitute a large portion of many plant genomes and play important roles in regulating gene expression driving genome evolution crop domestication. Despite advances understanding the functions mechanisms TEs, comprehensive review their integrated knowledge cutting-edge biotechnological applications TEs is still needed. We provide thorough overview that connects discoveries, mechanisms, technologies associated with TEs. discuss identification function driven by functional genomics, epigenetic regulation utilization active genomics engineering. In summary, expanding application will be beneficial to breeding synthetic biology future.

Language: Английский

Methylome and transcriptome joint analyses identify differentially expressed genes based on purebred and crossbred Tianjin-monkey Chicken

Animal Biotechnology, Journal Year: 2024, Volume and Issue: 35(1)

Published: Sept. 18, 2024

Tianjin-monkey Chicken is a locally bred naked neck poultry with limited population size. Herein, we intended to identify potential breed-related genes based on methylome and transcriptome analyses. Hy-line Brown were crossbred the individuals divided into three groups: PN (Purebred chicken(Tianjin-monkey Chicken)) group (n = 10); CN (Crossbred chicken) CF feathered 10). These 30 subjected whole genome bisulfite sequencing (WGBS) sequencing. Differential methylated regions detected by WGBS. No significant difference existed in naked-neck-related traits between chicken. CpG methylation level of promoter region differed PN, vs. By integrating results, four identified groups, 24 key great breeding. The enriched 32 GO terms 3 KEGG pathways, such as ion transport. was distinct groups. We for future breeding, valuable targeted breeding genetic enhancement production.

Language: Английский