Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
204, P. 107202 - 107202
Published: May 3, 2024
Plant-derived
extracellular
vesicles
(PDEV)
constitute
nanoscale
entities
comprising
lipids,
proteins,
nucleic
acids
and
various
components
enveloped
by
the
lipid
bilayers
of
plant
cells.
These
play
a
crucial
role
in
facilitating
substance
information
transfer
not
only
between
cells
but
also
across
different
species.
Owing
to
its
safety,
stability,
abundance
raw
materials,
this
has
found
extensive
utilization
recent
years
within
research
endeavors
aimed
at
treating
diseases.
This
article
provides
an
overview
pathways
biological
characteristics
PDEV,
along
with
prevalent
methods
employed
for
isolation,
purification,
storage.
Furthermore,
we
comprehensively
outline
therapeutic
implications
diverse
sources
PDEV
musculoskeletal
system
disorders.
Additionally,
explore
as
platforms
engineering
drug
carriers,
aiming
delve
deeper
into
significance
potential
contributions
realm
system.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 1, 2024
Abstract
Aortic
dissection
(AD)
is
a
severe
cardiovascular
disease
necessitating
active
therapeutic
strategies
for
early
intervention
and
prevention.
Nucleic
acid
drugs,
known
their
potent
molecule‐targeting
properties,
offer
potential
genetic
suppression
of
AD.
Piwi‐interacting
RNAs,
class
small
hold
promise
managing
diseases.
Limited
research
on
these
RNAs
AD
exists.
This
study
demonstrates
that
an
antagomir
targeting
heart‐apoptosis‐associated
piRNA
(HAAPIR)
effectively
regulates
vascular
remodeling,
mitigating
occurrence
progression
through
the
myocyte
enhancer
factor
2D
(Mef2D)
matrix
metallopeptidase
9
(MMP9)
pathways.
Green
tea‐derived
plant
exosome‐like
nanovesicles
(PELNs)
are
used
oral
administration
antagomir.
The
antagomir‐HAAPIR‐nanovesicle
complex,
after
purification
optimization,
exhibits
high
packing
rate,
while
resistant
to
enzyme
digestion.
Administered
mice,
complex
targets
aortic
lesion,
reducing
incidence
improving
survival.
Moreover,
MMP9
Mef2D
expression
decrease
significantly,
inhibiting
phenotypic
conversion
human
smooth
muscle
cells.
PELNs
encapsulate
antagomir‐HAAPIR
maintaining
stability,
mediating
transport
into
bloodstream,
delivering
sites.
Thus,
HAAPIR
target
persistent
clinical
prevention
treatment,
nanovesicle‐encapsulated
nucleic
acids
promising
providing
insights
other
targets.
Frontiers in Cell and Developmental Biology,
Journal Year:
2024,
Volume and Issue:
12
Published: April 3, 2024
Exosomes
are
small
extracellular
vesicles
secreted
by
cells,
ranging
in
size
from
30
to
150
nm.
They
contain
proteins,
nucleic
acids,
lipids,
and
other
bioactive
molecules,
which
play
a
crucial
role
intercellular
communication
material
transfer.
In
tumor
immunity,
exosomes
present
various
functions
while
the
following
two
of
great
importance:
regulating
immune
response
serving
as
delivery
carriers.
This
review
starts
with
introduction
formation,
compositions,
functions,
isolation,
characterization,
applications
exosomes,
subsequently
discusses
current
status
immunotherapy,
recent
exosome-based
immunity
regulation
antitumor
drug
delivery.
Finally,
challenge
future
prospects
proposed
hope
demonstrate
inspiration
for
targeted
readers
field.
Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: Sept. 17, 2024
The
discovery
of
novel
and
innovative
therapeutic
strategies
for
cancer
treatment
management
remains
a
major
global
challenge.
Exosomes
are
endogenous
nanoscale
extracellular
vesicles
that
have
garnered
increasing
attention
as
vehicles
advanced
drug
delivery
targeted
therapy.
attractive
physicochemical
biological
properties
exosomes,
including
increased
permeability,
biocompatibility,
extended
half-life
in
circulation,
reduced
toxicity
immunogenicity,
multiple
functionalization
strategies,
made
them
preferred
other
diseases.
Small
interfering
RNAs
(siRNAs)
remarkably
able
to
target
any
known
gene:
an
attribute
harnessed
knock
down
cancer-associated
genes
viable
strategy
management.
Extensive
research
on
exosome-mediated
siRNAs
targeting
diverse
types
has
yielded
promising
results
anticancer
therapy,
with
some
formulations
progressing
through
clinical
trials.
This
review
catalogs
recent
advances
siRNA
several
cancer,
the
manifold
benefits
minimal
drawbacks
such
systems.
Additionally,
we
highlighted
potential
plant-derived
exosomes
systems
treatment,
offering
numerous
advantages
scalability,
compared
traditional
methods.
These
their
unique
characteristics
effective
delivery,
represent
significant
advancement
nanomedicine
therapeutics.
Further
exploration
manufacturing
processes
mechanisms
could
significantly
advance
natural
medicine
enhance
efficacy
exosome-based
therapies.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
204, P. 107202 - 107202
Published: May 3, 2024
Plant-derived
extracellular
vesicles
(PDEV)
constitute
nanoscale
entities
comprising
lipids,
proteins,
nucleic
acids
and
various
components
enveloped
by
the
lipid
bilayers
of
plant
cells.
These
play
a
crucial
role
in
facilitating
substance
information
transfer
not
only
between
cells
but
also
across
different
species.
Owing
to
its
safety,
stability,
abundance
raw
materials,
this
has
found
extensive
utilization
recent
years
within
research
endeavors
aimed
at
treating
diseases.
This
article
provides
an
overview
pathways
biological
characteristics
PDEV,
along
with
prevalent
methods
employed
for
isolation,
purification,
storage.
Furthermore,
we
comprehensively
outline
therapeutic
implications
diverse
sources
PDEV
musculoskeletal
system
disorders.
Additionally,
explore
as
platforms
engineering
drug
carriers,
aiming
delve
deeper
into
significance
potential
contributions
realm
system.
