Impact of supplementing Lactobacillus fermentum MN–LF23 on the eradication of Helicobacter pylori with 14–day standard quadruple therapy: A randomized, double–blind, placebo–controlled trial DOI Creative Commons
Yuyang Zhao, Xiaokang Niu, Yong Zhang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Abstract Background: The effect of probiotics onHelicobacter pylori (Hp) infection demonstrates considerable heterogeneity. This study aims to elucidate the role Lactobacillus fermentum MN–LF23 (MN–LF23) in Hp–infected populations. Methods: A total 94 adult patients with confirmed Hp were enrolled this and randomly allocated placebo or MN–LF23 group. Patients initially received either along standard quadruple therapy for 2 weeks, followed by continued administration an additional 4 weeks. eradication Hp, serum levels inflammatory factors, alterations gastrointestinal symptoms assessed at weeks 0, 2, 6, while fecal samples collected metagenomic sequencing. Results: results showed no significant difference (P = 1) rate between group (85.11%) probiotic (82.98%). Following treatment, incidence constipation, dyspepsia, Gastrointestinal Symptom Rating Scale (GSRS) scores markedly lower < 0.05) compared those observed Throughout treatment process, there differences TNF–α IL–1β two groups. Compared group, exhibited a increase beneficial bacteria such as Lactobacillus fermentum, plantarum, Bifidobacterium longum, Coprococcus caltus, Clostridium butyricum. Conclusion: supplementation did not improve therapy. However, it significantly reduced overall GSRS score, improved digestive constipation symptoms, promoted proliferation intestine.

Language: Английский

Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition DOI Creative Commons
Antonino Glaviano,

Hannah Lau,

Lukas M. Carter

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 13, 2025

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, signaling molecules that interact promote growth therapeutic resistance. Elucidating the intricate interactions between cells TME crucial in understanding progression challenges. A critical process induced by epithelial-mesenchymal transition (EMT), wherein epithelial acquire mesenchymal traits, which enhance their motility invasiveness progression. By targeting various components TME, novel investigational strategies aim disrupt TME's contribution EMT, thereby improving efficacy, addressing resistance, offering a nuanced approach therapy. This review scrutinizes key players emphasizing avenues therapeutically components. Moreover, article discusses implications for resistance mechanisms highlights current toward modulation along with potential caveats.

Language: Английский

Citations

16
Helicobacter pylori and gastric cancer: mechanisms and new perspectives DOI Creative Commons

Yantao Duan,

Yonghu Xu,

Yi Dou

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 23, 2025

Gastric cancer remains a significant global health challenge, with Helicobacter pylori (H. pylori) recognized as major etiological agent, affecting an estimated 50% of the world's population. There has been rapidly expanding knowledge molecular and pathogenetic mechanisms H. over decades. This review summarizes latest research advances to elucidate underlying infection in gastric carcinogenesis. Our investigation reveals complex network involving STAT3, NF-κB, Hippo, Wnt/β-catenin pathways, which are dysregulated caused by pylori. Furthermore, we highlight role inducing oxidative stress, DNA damage, chronic inflammation, cell apoptosis—key cellular events that pave way for Emerging evidence also suggests effect on tumor microenvironment its possible implications immunotherapy. synthesizes current identifies gaps warrant further investigation. Despite progress our previous development pylori-induced cancer, comprehensive pylori's is crucial advancement prevention treatment strategies. By elucidating these mechanisms, aim provide more in-depth insights study pylori-related cancer.

Language: Английский

Citations

7
A review on probiotics and dietary bioactives: Insights on metabolic well-being, gut microbiota, and inflammatory responses DOI Creative Commons
Alice Njolke Mafe, Great Iruoghene Edo,

Osamah S. Majeed

et al.

Food Chemistry Advances, Journal Year: 2025, Volume and Issue: 6, P. 100919 - 100919

Published: Feb. 11, 2025

Language: Английский

Citations

6
Impact of Metabolites from Foodborne Pathogens on Cancer DOI Creative Commons
Alice Njolke Mafe, Dietrich Büsselberg

Foods, Journal Year: 2024, Volume and Issue: 13(23), P. 3886 - 3886

Published: Dec. 1, 2024

Foodborne pathogens are microorganisms that cause illness through contamination, presenting significant risks to public health and food safety. This review explores the metabolites produced by these pathogens, including toxins secondary metabolites, their implications for human health, particularly concerning cancer risk. We examine various such as Salmonella sp., Campylobacter Escherichia coli, Listeria monocytogenes, detailing specific of concern carcinogenic mechanisms. study discusses analytical techniques detecting chromatography, spectrometry, immunoassays, along with challenges associated detection. covers effective control strategies, processing techniques, sanitation practices, regulatory measures, emerging technologies in pathogen control. manuscript considers broader highlighting importance robust policies, awareness, education. identifies research gaps innovative approaches, recommending advancements detection methods, preventive policy improvements better manage foodborne metabolites.

Language: Английский

Citations

12
Unraveling the Role of Fusobacterium nucleatum in Colorectal Cancer: Molecular Mechanisms and Pathogenic Insights DOI Open Access

Linda Galasso,

Fabrizio Termite, Irene Mignini

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 368 - 368

Published: Jan. 23, 2025

Fusobacterium nucleatum, a gram-negative anaerobic bacterium, has emerged as significant player in colorectal cancer (CRC) pathogenesis. The bacterium causes persistent inflammatory reaction the mucosa by stimulating release of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α, creating an environment conducive to progression. F. nucleatum binds penetrates epithelial cells through adhesins such FadA, impairing cell junctions encouraging epithelial-to-mesenchymal transition (EMT), which is associated with advancement. Additionally, modulates host immune system, suppressing activity conditions favorable for tumor growth. Its interactions gut microbiome contribute dysbiosis, further influencing carcinogenic pathways. Evidence indicates that can inflict DNA damage either directly via reactive oxygen species or indirectly environment. it triggers oncogenic pathways, especially Wnt/β-catenin signaling pathway, promotes growth longevity. Moreover, alters microenvironment, impacting behavior, metastasis, therapeutic responses. purpose this review elucidate molecular mechanisms contributes CRC. Understanding these crucial development targeted therapies diagnostic strategies CRC nucleatum.

Language: Английский

Citations

1
Advancements in Antibacterial Therapy: Feature Papers DOI Creative Commons
Giancarlo Angeles Flores,

Gaia Cusumano,

Roberto Venanzoni

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 557 - 557

Published: March 1, 2025

Antimicrobial resistance (AMR) is a growing global health crisis that threatens the efficacy of antibiotics and modern medical interventions. The emergence multidrug-resistant (MDR) pathogens, exacerbated by misuse in healthcare agriculture, underscores urgent need for innovative solutions. (1) Background: AMR arises from complex interactions between human, animal, environmental health, further aggravated overuse inadequate regulation antibiotics. Conventional treatments are increasingly ineffective, necessitating alternative strategies. Emerging approaches, including bacteriophage therapy, antimicrobial peptides (AMPs), nanotechnology, microbial extracellular vesicles (EVs), CRISPR-based antimicrobials, provide novel mechanisms complement traditional combating resistant pathogens. (2) Methods: This review critically analyzes advanced antibacterial strategies conjunction with systemic reforms such as stewardship programs, One Health framework, surveillance tools. These methods can enhance detection, guide interventions, promote sustainable practices. Additionally, economic, logistical, regulatory challenges impeding their implementation evaluated. (3) Results: technologies, CRISPR exhibit promising potential targeting mechanisms. However, disparities resource distribution barriers hinder widespread adoption. Public–private partnerships agriculture practices critical to overcoming these obstacles. (4) Conclusions: A holistic integrated approach essential mitigating impact AMR. By aligning therapeutic policies, fostering interdisciplinary collaboration, ensuring equitable distribution, we develop response this 21st-century challenge.

Language: Английский

Citations

1
Gastrointestinal Microbiota in Gastric Cancer: Potential Mechanisms and Clinical Applications—A Literature Review DOI Open Access
Mengjiao Wu,

Chenjun Tian,

Zhenwei Zou

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(20), P. 3547 - 3547

Published: Oct. 21, 2024

Emerging evidence highlights the crucial role of gastrointestinal microbiota in pathogenesis gastric cancer.

Language: Английский

Citations

5
Pumpkin Soluble Dietary Fiber instead of Insoluble One Ameliorates Hyperglycemia via the Gut Microbiota–Gut–Liver Axis in db/db Mice DOI

Fang Yan,

Xinze Wang, Yue Du

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 73(2), P. 1293 - 1307

Published: Dec. 31, 2024

Pumpkin extract has been shown to alleviate hyperglycemic symptoms by improving glucose metabolism disorders. However, the specific active components responsible for its hypoglycemic effects and underlying molecular mechanisms remain unclear. In this study, db/db mice underwent a 4-week dietary intervention with two pumpkin flours (PF1 PF2), total fiber (TDF), soluble (SDF), insoluble (IDF), acarbose serving as positive control. Our results revealed that significantly altered gut microbiota, characterized reduction in diabetes-related bacteria an increase short-chain fatty acid (SCFA)-producing bacteria, including Bacteroides, Akkermansia, Lachnospiraceae_NK4A136 group. Additionally, increased fecal SCFA levels upregulated expression of receptor GPR43, potentially promoting GLP-1 secretion. Notably, reduced fasting blood serum insulin inhibited gluconeogenesis. This effect may be ascribed inhibition cAMP/PKA/CREB signaling pathway coupled activation PI3K/AKT pathway. research indicated flour alleviated hyperglycemia through gut-liver axis, SDF contributing most effect. These findings suggest serve adjunct nutritional ameliorate hyperglycemia.

Language: Английский

Citations

4
Oral microbiota in colorectal cancer: Unraveling mechanisms and application potential DOI
X. Q. Zhang, Yixin Chen, Yuwei Xia

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: 365, P. 123462 - 123462

Published: Feb. 11, 2025

Language: Английский

Citations

0
The Impact of Microbiota on Musculoskeletal Injuries DOI Creative Commons

Giada La Placa,

Marcello Covino, Marcello Candelli

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 554 - 554

Published: April 7, 2025

Musculoskeletal injuries comprise a wide range of physical conditions impacting the coordination bones, muscles, and joints. Estimations suggest that close to one-third world’s population will experience musculoskeletal or non-musculoskeletal injury at some point in their life. affect athletes, office workers, industrial older adults, children every year. Among individuals over age 65, disproportionately women, limiting ability maintain an active professional life engage leisure activities during retirement. The field therapy has recently expanded build understanding complex, non-linear interactions between gut microbiota system. There is unexpected connection both pain healing process following injuries. Understanding mechanisms microbiota’s influence on these could inform healthcare strategies aimed prevention recovery. For patients who suffer from are risk developing injuries, analyzing composition plays crucial role patient stratification, which can significantly enhance effectiveness treatment strategies.

Language: Английский

Citations

0