The
pandemic
coronavirus
(CoV)
disease
2019
(COVID-19)
caused
by
severe
acute
respiratory
syndrome
CoV-2
(SARS-CoV-2)
is
a
major
threat
to
global
human
health.
To
date,
there
are
no
approved
prophylactics
or
therapeutics
available
for
COVID-19.
Reverse
genetics
powerful
approach
understand
factors
involved
in
viral
pathogenesis,
antiviral
screening,
and
vaccine
development.
In
this
study,
we
describe
the
feasibility
of
generating
recombinant
SARS-CoV-2
(rSARS-CoV-2)
transfection
single
bacterial
artificial
chromosome
(BAC).
Importantly,
rSARS-CoV-2
possesses
same
phenotype
as
natural
isolate
vitro
vivo
.
This
first
description
BAC-based
reverse
system
time
that
an
has
been
shown
be
phenotypically
identical
validated
animal
model
infection.
will
facilitate
study
development
treatment
Journal of Nanobiotechnology,
Journal Year:
2020,
Volume and Issue:
18(1)
Published: Sept. 5, 2020
Abstract
Incidents
of
viral
outbreaks
have
increased
at
an
alarming
rate
over
the
past
decades.
The
most
recent
human
coronavirus
known
as
COVID-19
(SARS-CoV-2)
has
already
spread
around
world
and
shown
R
0
values
from
2.2
to
2.68.
However,
ratio
between
mortality
number
infections
seems
be
lower
in
this
case
comparison
other
coronaviruses
(such
severe
acute
respiratory
syndrome
(SARS-CoV)
Middle
East
(MERS-CoV)).
These
tested
limits
healthcare
systems
posed
serious
questions
about
management
using
conventional
therapies
diagnostic
tools.
In
regard,
use
nanotechnology
offers
new
opportunities
for
development
novel
strategies
terms
prevention,
diagnosis
treatment
infections.
review,
we
discuss
virus
by
nano-based
materials,
such
disinfectants,
personal
protective
equipment,
nanocarrier
systems,
treatments
vaccine
development,
well
challenges
drawbacks
that
need
addressing.
Sensors International,
Journal Year:
2020,
Volume and Issue:
1, P. 100021 - 100021
Published: Jan. 1, 2020
India,
which
has
the
second-largest
population
in
world
is
suffering
severely
from
COVID-19
disease.
By
May
18th,
India
investigated
∼1
lakh
(0.1million)
infected
cases
COVID-19,
and
as
of
11th
July
equalled
8
lakhs.
Social
distancing
lockdown
rules
were
employed
however
had
an
additional
impact
on
economy,
human
living,
environment.
Where
a
negative
was
observed
for
economy
life,
environment
got
positive
one.
How
dealt
can
potentially
deal
with
these
three
factors
during
post
situation
been
discussed
here.
