Ambient PM gross β-activity and glucose levels during pregnancy

Environmental Health, Journal Year: 2021, Volume and Issue: 20(1)

Published: June 14, 2021

Exposure to ionizing radiation has been associated with insulin resistance and type 2 diabetes. In light of recent work showing an association between ambient particulate matter (PM) gross β-activity gestational diabetes mellitus (GDM) among pregnant women, we examined pregnancy glucose levels in relation PM better understand this pathway.Our study included 103 participants receiving prenatal care at Beth Israel Deaconess Medical Center Boston, MA. was obtained from US Environmental Protection Agency's RadNet program monitors, blood were the non-fasting challenge test performed clinically as first step 2-step GDM screening test. For each exposure window (i.e., moving average same-day, one-week, first-trimester, second-trimester β-activity), fitted generalized additive models adjusted for clinical characteristics, socio-demographic factors, temporal variables, aerodynamic diameter ≤ 2.5 μm (PM2.5). Subgroup analyses by maternal age body mass index also conducted.An interquartile range increase during second trimester 17.5 (95% CI: 0.8, 34.3) mg/dL concentration. Associations stronger younger overweight/obese participants. Our findings suggest that highest compared lowest quartile one-week 17.0 - 4.0, 38.0) higher levels. No associations observed same-day first-trimester windows. PM2.5 not any our data.Exposure patients, implications how novel environmental factor could impact health.

Language: Английский

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Could Subtle Obstetrical Brachial Plexus Palsy Be Related to Unilateral B Glenoid Osteoarthritis?

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(6), P. 1196 - 1196

Published: March 12, 2021

Background: Several factors associated with B glenoid are also linked obstetrical brachial plexus palsy (OBPP). The purpose of this observational study was to determine the incidence OBPP risk in type patients. Methods: A cohort 154 patients (68% men, 187 shoulders) aged 63 ± 17 years glenoids completed a questionnaire comprising history perinatal characteristics related OBPP. literature review performed following Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) estimate general population. Results: Twenty-seven (18%) reported one or more factors, including shoulder dystocia (n = 4, 2.6%), macrosomia >4 kg 5, 3.2%), breech delivery 6, 3.9%), fetal distress 8, 5.2%), maternal diabetes 2, 1.3%), clavicular fracture forceps 2.6%). comparison recent suggested that most were within normal range, although dystocia, vaginal deliveries exceeded average rates. Conclusion: Perinatal did not occur higher frequency Walch OA compared population, some them high range.

Language: Английский

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MicroRNA-1592 in the Bone Marrow Mesenchymal Stem Cell-Derived Exosomes Inhibits the Glioma Development In Vivo and In Vitro

Journal of Biomaterials and Tissue Engineering, Journal Year: 2022, Volume and Issue: 12(7), P. 1356 - 1363

Published: March 26, 2022

This study evaluated the role of miRNA-1592 (miR-1592) carried by exosomes that originated from bone marrow mesenchymal stem cell (BMSC) in glioma. BMSCs were cultured and identified, followed being co-cultured with glioma cells to measure invasion, metastasis, apoptosis transwell assay flow cytometry, proliferation MTT, PI3K/AKT signal protein expression western blot. BMSC-originated different concentrations used as a treatment strategy for established tumor models. The volume was measured tissues harvested immunohistochemistry immunoblot analysis. After co-culture exosomes, showed an up-regulated transcription miR-1592, along inhibited phosphorylation activation pathway. Moreover, exhibited reduced migration invasiveness In Vitro , which accompanied diminished levels proteins involved cellular invasiveness. Simultaneously, can restrain via facilitating Vivo . conclusion, exosome-encapsulated microRNA-1592 suppress development through interfering signaling

Language: Английский

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