Neonicotinoid Insecticides and Their Metabolites Can Pass through the Human Placenta Unimpeded

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(23), P. 17143 - 17152

Published: Nov. 28, 2022

Studies on neonicotinoid (NEO) exposure in pregnant women and fetuses are scarce, transplacental transfer of these insecticides is unknown. In this study, parent NEOs (p-NEOs) their metabolites (m-NEOs) were determined 95 paired maternal (MS) cord serum (CS) samples collected southern China. Imidacloprid was the predominant p-NEO both CS MS samples, found at median concentrations 1.84 0.79 ng/mL, respectively, whereas N-desmethyl-acetamiprid most abundant m-NEO (median: 0.083 ng/mL) (0.13 ng/mL). The efficiencies (TTEs) p-NEOs m-NEOs high, ranging from 0.81 (thiamethoxam, THM) to 1.61 (olefin-imidacloprid, of-IMI), indicating efficient placental insecticides. Moreover, transport appears be passive structure-dependent: cyanoamidine such as acetamiprid thiacloprid had higher TTE values than nitroguanidine NEOs, namely, clothianidin THM. Multilinear regression analysis revealed that several associated significantly with hematological parameters related hepatotoxicity renal toxicity. To our knowledge, first occurrence distribution maternal-fetal samples.

Language: Английский

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Adverse health effects of emerging contaminants on inflammatory bowel disease

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 24, 2023

Inflammatory bowel disease (IBD) is becoming increasingly prevalent with the improvement of people's living standards in recent years, especially urban areas. The emerging environmental contaminant a newly-proposed concept progress industrialization and modernization, referring to synthetic chemicals that were not noticed or researched before, which may lead many chronic diseases, including IBD. contaminants mainly include microplastics, endocrine-disrupting chemicals, chemical herbicides, heavy metals, persisting organic pollutants. In this review, we summarize adverse health effect these on humans their relationships Therefore, can better understand impact new IBD, minimize exposures, lower future incidence

Language: Английский

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Association of Prenatal Exposure to Organophosphate, Pyrethroid, and Neonicotinoid Insecticides with Child Neurodevelopment at 2 Years of Age: A Prospective Cohort Study

Environmental Health Perspectives, Journal Year: 2023, Volume and Issue: 131(10)

Published: Oct. 1, 2023

Widespread insecticide exposure might be a risk factor for neurodevelopment of our children, but few studies examined the mixture effect maternal coexposure to organophosphate insecticides (OPPs), pyrethroids (PYRs), and neonicotinoid (NNIs) during pregnancy on child neurodevelopment, critical windows are unknown.We aimed evaluate association prenatal multiple with children's identify exposure.Pregnant women were recruited into prospective birth cohort study in Wuhan, China, from 2014-2017. Eight metabolites OPPs (mOPPs), three PYRs (mPYRs), nine NNIs (mNNIs) measured 3,123 urine samples collected at their first, second, third trimesters. Children's [mental development index (MDI) psychomotor (PDI)] was assessed using Bayley Scales Infant Development 2 years age (N=1,041). Multivariate linear regression models, generalized estimating equation weighted quantile sum (WQS) used estimate between scores. Potential sex-specific associations also examined.Single chemical analysis suggested higher urinary concentrations some first trimester significantly associated lower MDI PDI scores, more prominent among boys. Each 1-unit increase ln-transformed two mOPPs, 3,5,6-trichloro-2-pyridinol 4-nitrophenol, decrease 3.16 points [95% confidence interval (CI): -5.59, -0.74] 3.06 (95% CI: -5.45, -0.68) respectively boys' that trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid (trans-DCCA; an mPYR) 2.24 -3.89, -0.58) scores 1.90 -3.16, -0.64) respectively. Significantly positive biomarker [e.g., dimethyl phosphate (a nonspecific mOPP) desmethyl-clothianidin relatively specific mNNI)] observed. Using repeated holdout validation, 1-quartile WQS (in negative direction) 3.02 -5.47, -0.57) boys, trans-DCCA contributed most (18%).Prenatal levels certain particularly Early may sensitive window such effect. Future needed confirm findings. https://doi.org/10.1289/EHP12097.

Language: Английский

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Assessing human exposure to pesticides and mycotoxins: optimization and validation of a method for multianalyte determination in urine samples

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(8), P. 1935 - 1949

Published: Feb. 7, 2024

Humans are exposed to an increasing number of contaminants, with diet being one the most important exposure routes. In this framework, human biomonitoring is considered gold standard for evaluating chemicals. Pesticides and mycotoxins chemicals special concern due their health implications. They constitute predominant border rejection notifications food feed in Europe USA. However, current studies focused on a limited compounds do not evaluate pesticides together. study, analytical method has been developed determination 30 23 urine samples. A salting-out liquid-liquid extraction (SALLE) procedure was optimized achieving recoveries between 70 120% almost all limits as lower when QuEChERS applied. The were then determined by liquid chromatography coupled triple quadrupole mass spectrometry. Different chromatographic conditions columns tested, selecting Hypersild aQ column best option. Finally, applied analysis 45 samples, which organophosphate pyrethroid (detection rates (DR) 82% 42%, respectively) ochratoxin deoxynivalenol (DR 51% 33%, detected compounds. proposed involves simultaneous diverse set mycotoxins, including relevant metabolites, urine. It serves essential tool presence highly prevalent contaminants modern society.

Language: Английский

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Removal of neonicotinoid insecticides from water in various treatment processes: A review

Critical Reviews in Environmental Science and Technology, Journal Year: 2024, Volume and Issue: 54(18), P. 1307 - 1339

Published: Feb. 9, 2024

The extensive application of neonicotinoid insecticides (NNIs) has resulted in its worldwide detection waters, leading to risks human health and ecology safety. Presently, various remediation techniques for NNIs have been developed. However, the critical reviews concerning approaches elimination from water are limited. Considering tremendous efforts made research topic removal recently, this study systematacially reviewed current advances on approaches, including adsorption, Fenton, ozonation, photodegradation, sulfate radicals based-advanced oxidation processes (AOPs), electrochemical AOPs, percarbonate-based periodate-based microbial remediation, phytoremediation. Moreover, by these methods critically discussed, compared, analyzed. Furthermore, mechanisms different treatment summarized detail. Finally, challenges perspectives proposed. This highlights progresses technologies proposes future needs area, which will provide support further researches halt contamination.

Language: Английский

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Comprehensive analysis of neonicotinoids in Chinese commercial honey and pollen: A corresponding health risk assessment for non-targeted organisms

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170937 - 170937

Published: Feb. 14, 2024

Language: Английский

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Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117788 - 117788

Published: Jan. 1, 2025

Neonicotinoids exposure was found to induce thyroid dysfunction. However, there lack of direct evidence between neonicotinoids and hormone (TH) disruption in population study, especially children, which limits the understanding on their health hazard. To fill this knowledge gap, we conducted a cross-sectional study children rural area South China (n = 88), analyzed urinary ten (including metabolites), serum TH, thyroxine-binding globulin (TBG), stimulating (TSH) levels. Based linear regression, generalized additive model, Bayesian kernel machine levels were be correlated with TBG, TSH levels, stronger effects for metabolites than parent compounds most cases. Mixture had significantly positive effect free triiodothyronine (T3). N-desmethyl-acetamiprid (N-dm-ACE) negatively associated T3 female, corresponded much lower female male. Also, N-dm-ACE non-monotonic thyroxine Some interactive lead cadmium TH disruption. The results provide an highlight need explore safeguard children.

Language: Английский

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High sensitivity electrochemical detection of ultra-trace imidacloprid in fruits and vegetables using a Fe-rich FeCoNi-MOF

Food Chemistry, Journal Year: 2022, Volume and Issue: 408, P. 135221 - 135221

Published: Dec. 15, 2022

Language: Английский

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Exposure to multiple neonicotinoid insecticides, oxidative stress, and gestational diabetes mellitus: Association and potential mediation analyses

Environment International, Journal Year: 2023, Volume and Issue: 179, P. 108173 - 108173

Published: Aug. 25, 2023

As the most extensively used insecticides worldwide, neonicotinoid (NNIs) have received a growing global concern over their adverse health effects. This study aimed to assess associations of urinary concentrations NNIs in early pregnancy with gestational diabetes mellitus (GDM) and mediation roles oxidative DNA damage, RNA lipid peroxidation associations. With prospective nested case-control study, 519 GDM cases controls were matched on infant's sex maternal age. Urinary biomarkers exposure stress measured pregnancy. We estimated single mixture metabolites by conditional logistic regression quantile g-computation models, respectively. The mediating evaluated structural equation model. odds significantly increased 15 %, 18 26 42 49 13 % each unit increment ln-transformed imidacloprid (IMI), imidacloprid-olefin (IMI-olefin), desnitro-imidacloprid (DN-IMI), thiamethoxam (THM), clothianidin, desmethyl-clothianidin, Exposure was associated (adjusted OR: 1.76; 95 %CI: 1.45, 2.13). Advanced age enhanced 5-hydroxy-IMI, DN-IMI, IMI-olefin (P < 0.05), being overweight/obese before strengthened effects IMI, IMI-olefin, THM 0.05). In association GDM, proportions mediated overall 9.8 11.8 14.5 respectively individual pre-pregnancy BMI may modify association. possible mechanism underlying between involve damage nucleic acids.

Language: Английский

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Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(5)

Published: May 1, 2024

Abstract Acetamiprid is a pesticide active substance with insecticidal action whose approval was renewed by Commission Implementing Regulation (EU) 2018/113. In January 2022, the EFSA PPR Panel published statement following request from European to advise on human health or environment based new scientific evidence presented France during decision-making phase. July means of further mandate received Commission, requested provide advice if information and any other that has become available since assessment conducted for renewal in 2018 warrant re-evaluation (i) toxicological parameters used risk acetamiprid process, including endpoints; (ii) residue definition products plant origin; (iii) safety existing maximum levels (MRLs). Meanwhile, applicant EU submitted toxicology studies regarding profile metabolite IM-2-1. Furthermore, made aware several recent publications literature were after searches EFSA. As data could affect expected deliver through 2022 mandate, consider this revised September 2023. regards point statement, addressed an Working Group integrating all evidence. The results weight indicated there are major uncertainties body developmental neurotoxicity (DNT) properties therefore needed come more robust mechanistic understanding enable appropriate hazard assessment. view these uncertainties, WG proposed lower acceptable daily intake (ADI) acute reference dose (ARfD) 0.025 0.005 mg/kg (per day). A leafy fruit crops as sum N-desmethyl-acetamiprid (IM-2-1), expressed acetamiprid. Regarding pulses/oilseeds, root cereals, did not indicate need modify assessment, which remains parent enforcement, because still sufficient marker residues crop groups. Considering health-based guidance values derived present consumer been identified 38 MRLs currently place Regulation. Consequently, recommended commodities fall-back Good Agricultural Practices within ad hoc call. Some proposals require management considerations.

Language: Английский

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