Multi- and Transgenerational Developmental Impairments Are Induced by Decabromodiphenyl Ethane (DBDPE) in Zebrafish Larvae

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(7), P. 2887 - 2897

Published: Feb. 13, 2023

A novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant; hence, the knowledge of its long-term toxic effects and underlying mechanism would be critical for further health risk assessment. In present study, multi- transgenerational toxicity DBDPE was investigated in zebrafish upon life cycle exposure at environmentally relevant concentrations. The significantly increased malformation rate declined survival specifically occurred unexposed F2 larvae suggested development by DBDPE. changing profiles revealed transcriptome DNA methylome confirmed an susceptibility figured out potential disruptions glycolipid metabolism, mitochondrial energy neurodevelopment. changes biochemical indicators such as ATP production disturbance whereas alterations neurotransmitter contents light–dark stimulated behavior provided evidence neurotoxicity zebrafish. Our findings also highlighted necessity considering impacts when evaluating wild animals well human beings pollutants.

Language: Английский

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Toxicity of microplastics and nanoplastics to Daphnia magna: Current status, knowledge gaps and future directions

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 167, P. 117208 - 117208

Published: July 29, 2023

Language: Английский

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Overview of deltamethrin residues and toxic effects in the global environment

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(8)

Published: July 2, 2024

Language: Английский

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Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction

Environmental Toxicology, Journal Year: 2022, Volume and Issue: 37(8), P. 2033 - 2043

Published: April 21, 2022

Deltamethrin (DLM) is a widely used and highly effective insecticide. DLM exposure harmful to animal human. Quail, as bird model, has been in the field of toxicology. However, there little information available literature about quail cerebrum damage caused by DLM. Here, we investigated effect on neurons. Four groups healthy quails were assigned (10 each group), respectively given 0, 15, 30, 45 mg/kg gavage for 12 weeks. Through measurements cerebrum, it was found that induced obvious histological changes, oxidative stress, neurons apoptosis. To further explore possible molecular mechanisms, performed real-time quantitative PCR detect expression endoplasmic reticulum (ER) stress-related mRNA such glucose regulated protein 78 kD, activating transcription factor 6, inositol requiring enzyme, kinase RNA (PKR)-like ER kinase. In addition, detected ATP content evaluate functional status mitochondria. The study showed significantly increased decreased tissues. These results suggest chronic induces apoptosis via promoting stress mitochondrial dysfunction. Furthermore, our provide novel explanation DLM-induced avian

Language: Английский

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Evaluation and Mechanistic Study of Transgenerational Neurotoxicity in Zebrafish upon Life Cycle Exposure to Decabromodiphenyl Ethane (DBDPE)

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(44), P. 16811 - 16822

Published: Oct. 25, 2023

The novel brominated flame retardant decabromodiphenyl ethane (DBDPE) has become a ubiquitous emerging pollutant in the environment, which may evoke imperceptible effects humans or wild animals. Hence this study, zebrafish embryos were exposed to DBDPE (0, 0.1, 1, and 10 nM) until sexual maturity (F0), F1 F2 generations cultured without further exposure study multi- transgenerational toxicity underlying mechanism. growth showed sex-different changing profiles across three generations, social behavior confirmed neurotoxicity adult upon life cycle DBDPE. Furthermore, maternal transfer of was not detected, whereas parental neurotransmitters zygotes specifically disturbed offspring. A lack changes generation opposite trends F0 observed series indicators for DNA damage, methylation, gene transcription. Taken together, at environmentally relevant concentrations could induce zebrafish. Our findings also highlighted potential impacts on gregarious fish, would face higher risks from predators.

Language: Английский

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Systematic evaluation of the toxicological effects of deltamethrin exposure in zebrafish larvae

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 100, P. 104155 - 104155

Published: May 18, 2023

Language: Английский

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Preparation of peptides against immunocomplex of deltamethrin and application in noncompetitive lateral flow immunoassay

Food Chemistry, Journal Year: 2025, Volume and Issue: 471, P. 142757 - 142757

Published: Jan. 5, 2025

Language: Английский

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Effects of daily exposure to pyrethroid pesticides during infancy on children neurodevelopment at age four: a prospective study in rural Yunnan, China

NeuroToxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Frontier of toxicology studies in zebrafish model

Journal of Applied Toxicology, Journal Year: 2023, Volume and Issue: 44(4), P. 488 - 500

Published: Sept. 12, 2023

Abstract Based on the 87 original publications only from quartiles 1 and 2 of Journal Citation Report (JCR) collected by major academic databases (Science Direct, Web Science, PubMed, Wiley) in 2022, frontier toxicology studies zebrafish model is summarized. Herewith, a total six aspects covered such as developmental, neurological, cardiovascular, hepatic, reproductive, immunizing toxicities. The tested samples involve chemicals, drugs, new environmental pollutants, nanomaterials, its derivatives, along with those related mechanisms. This report may provide focus benefit to researchers engaging for environment, medicine, food, other fields.

Language: Английский

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The relationship between deltamethrin-induced behavioral changes and acetylcholinesterase activity in zebrafish embryos or larvae based on transcriptome

Frontiers in Veterinary Science, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 23, 2025

Background Deltamethrin (DM) is a broad-spectrum insecticide that widely used to control agricultural pests. Recently, DM has posed potential threat the health of infants and young children, this because environmental food pollution caused by extensive use DM. Methods In study, zebrafish ( Danio rerio ) embryos were as experimental animals quantify behavioral changes larvae induced explore relationship between acetylcholinesterase activity. Results The results showed an increase in coiling movement, heart rate, apoptosis brain early or larvae. It also decrease expression acetylcholinesterase-associated genes activity acetylcholinesterase, which led content. transcriptome data low concentration acetylcholine-related gene signaling pathways. above suggest doses may induce neurodegeneration exposure inhibits leading cell Micro-injection at 2–4 stage knocked down overexpressed behavior enzyme had some effects. Conclusion This study explored change provide basis for treatment poisoning aquaculture.

Language: Английский

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