Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 295, P. 118154 - 118154
Published: April 1, 2025
2-Hydroxy-4-n-octyloxybenzophenone (UV-531) is a UV absorber widely used in infrastructure, cosmetics, and rubber products. The previous study found that UV-531 exposure irritate the skin interfere with androgen secretion. However, developmental toxicity neurotoxic effects of are still at an exploratory stage, on environment living organisms need to be further explored. Here, we exposed zebrafish environmental relevant doses (0.1, 0.2, 0.4, 0.8 1.6 μg/L) observed no significant toxicity, but neurotoxicity. We assessed locomotor ability responsiveness by general locomotion light/dark challenge. Changes dopaminergic (DA) neurons were using transgenic slc18a2:GFP. cerebral vessels blood-brain barrier (BBB) fli1:GFP. Gene expression was detected transcriptome real-time qPCR. effect calcium homeostasis determined measuring Ca2+ levels. Microglia status situ hybridization. It treatment resulted reduced activity, DA injury, damage, BBB leakage, imbalance, abnormal genes related neurodevelopment function. RNA-seq results indicated import across plasma membrane highly associated UV-531-induced neurotoxicity cacna1aa cacna1ab key regulators. These findings suggest induced imbalance caused upregulating may contribute multiple sclerosis (MS). Accordingly, triggered neuroinflammation, injured myelin, ultimately leading development MS-like symptoms, including decreased external stimuli, microglia activation, dysregulation mbp MS-related ahsg1, btg1, grna. In summary, neurological damage led symptoms. Given organisms, safe dose range should established.
Language: Английский
Citations
0Application of catalytic wet peroxide oxidation for sunscreen agents breakdown
Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(2), P. 112410 - 112410
Published: March 5, 2024
Sunscreen agents are chemical compounds widely used nowadays for skin protection from UV sunlight. Recently, their ubiquitous occurrence in aquatic systems has been evidenced, which poses a high risk the environment and human health as they associated with endocrine disrupting activity, reproductive toxicity, genotoxicity. In this work, feasibility of an economically environmentally friendly catalytic system based on thermally modified natural magnetite hydrogen peroxide (Fe3O4-R400/H2O2), evaluated degradation two representative sunscreen agents: benzophenone-3 (BP-3) 4-aminobenzoic acid (PABA) wastewater. The experiments were conducted under circumneutral pH (pH0 = 5), temperature control (25 ºC). Both (500 μg L-1) successfully removed water by using relatively low catalyst concentration (0.5 g theoretical stoichiometric H2O2 dose complete oxidation (~2.3 mg L-1). Afterwards, operating condition study was performed BP-3, given its predominant fresh waters, analysing influence (1.2-4.6 L-1), (0.1-0.5 (25-45 From evolution identified by-products, reaction pathway proposed according to BP-3 gives rise several aromatic intermediates, finally evolve short-chain organic acids. generation such by-products led considerably ecotoxicity increase initial stages reaction, but non-toxic effluents ultimately achieved. Notably, mineralization yield reached above 60%. As proof concept, demonstrated real matrices (WWTP effluent surface water).
Language: Английский
Citations
3Sustainable Assessment of the Environmental Activities of Major Cosmetics and Personal Care Companies
Sustainability, Journal Year: 2023, Volume and Issue: 15(18), P. 13286 - 13286
Published: Sept. 5, 2023
The cosmetics and personal care industry has, by its nature, contributed to global environmental issues such as climate change, waste, water scarcity, habitat destruction, air pollution. Therefore, it is more important than ever for the companies be responsible proactive in addressing issues. Meanwhile, complexity of has never been greater. roles not only brand but also OEM/ODM retail are becoming increasingly important, boundaries collapsing. Despite urgency issues, there a lack research on specific practical activities companies, responsibilities retailers have overlooked. need this study was recognized. purpose expand scope assessment include general identify actual concrete being carried out. study, keywords cosmetics, environmental, eco-friendly, sustainable, which recently become topics discussion, were empirically analyzed. This selected analyzed 18 out 28 annual reports, nonfinancial statements, sustainability reports 16 cosmetics- personal-care-related companies. In addition, 456 articles found through PubMed, Google Scholar, Google, Scopus, final 108 referenced using PRISMA flow chart. novelty is, first, fact that identified strategies practices with respect Second, established common standards compared corporate activities. Third, included retailers, whose influence increasing recent years, understand status eco-friendly across industry. makes contribution encouraging comparing evaluating laying foundation development framework assessment. recognizes activity behavior whole contributes companies’ suggesting how use performance materials assess their
Language: Английский
Citations
7Role of benzophenone-3 additive in the effect of polyethylene microplastics on Daphnia magna population dynamics
Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 270, P. 106901 - 106901
Published: March 14, 2024
Language: Английский
Citations
2Evaluation of acute toxicity of an emerging contaminant Oxybenzone on an ecologically important aquatic macrophyte Lemna minor
Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 108, P. 104437 - 104437
Published: April 10, 2024
Language: Английский
Citations
2Understudied and underestimated impacts of organic UV filters on terrestrial ecosystems
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 953, P. 176008 - 176008
Published: Sept. 3, 2024
Language: Английский
Citations
2Effect of Intramolecular Hydrogen Bond Formation on the Abraham Model Solute Descriptors for Oxybenzone
Liquids, Journal Year: 2024, Volume and Issue: 4(3), P. 647 - 662
Published: Sept. 16, 2024
Solute descriptors derived from experimental solubility data for oxybenzone dissolved in 21 different organic solvents indicate that the hydrogen atom on hydroxyl functional group forms an intramolecular bond with lone electron pair oxygen of neighboring >C=O group. Group contribution methods developed estimating Abraham model solute molecule’s Canonical SMILES code significantly over-estimate model’s acidity descriptor oxybenzone. An informed user-modified is proposed to identify which atoms are involved H-bond formation. The identified atom(s) can be used define a new functional/fragment and numerical value.
Language: Английский
Citations
2Biochemical responses of the mussel Perna perna after exposure to environmental concentrations of the UV filter Benzophenone-3
Xenobiotica, Journal Year: 2023, Volume and Issue: 53(4), P. 309 - 319
Published: April 3, 2023
AbstractAbstractPersonal care products, such as UV filters, are frequently present in aquatic ecosystems, but studies on their impact marine organisms still scarce. Here we addressed the effects of benzophenone-3 (BP-3) antioxidant status Perna perna mussels exposed to concentrations 0.1 and 3 μg.L−1 for 72 h 7 days. Glutathione peroxidase (GPx), glutathione reductase (GR), S-transferase (GST), glucose-6-phosphate dehydrogenase (G6PDH) activity lipoperoxidation (MDA) were evaluated gills. A significant reduction (p < 0.05) G6PDH GPx was observed after exposure days µg.L−1. However, no differences GST MDA levels, independently time. Principal component analysis (PCA) showed an association BP-3 highest concentration with GR at only exposure. Similarly, integrated biomarker response (IBR) demonstrated alterations. In conclusion, environmentally relevant altered auxiliary enzymes, which could cause long-term damage P.perna mussels. The need implement more efficient techniques wastewater treatment systems is pointed out, especially summer, when filters used abundantly.Keywords: Oxybenzonebiomarkersbivalveoxidative stresssunscreen AcknowledgementsThe authors grateful 'Coordenação de Aperfeiçoamento Pessoal Nível Superior - CAPES' scholarship Gabriel S. Cruz (PPGAQI UFSC) 'Conselho Nacional Desenvolvimento Científico e Tecnológico CNPq', process n° 3110099/2014-0, financial resources provided execution this work. Miguel Saldaña-Serrano recipient a PhD fellowship 'Programa Estudantes-Convênio Pós-Graduação (PEC-PG/2018), Coordenação CAPES'. Micheli R. Castro post-doctoral fellow from CAPES (PNPD 2018). We – CNPq' granting undergraduate scientific initiation Coutinho (PIBIC/CNPq). also farm 'Paraíso das Ostras' (Florianópolis, SC, Brasil) animal supply Laboratory Marine Molluscs (LMM UFSC), partnership maintenance, initial acclimation, microalgae feed To Research Group Ecotoxicology Applied Aquatic Organisms (ECOBIOTOX FURG), assistance chemical water samples. Ph.D Clarissa P. Ferreira preparation graphic abstract manuscript.Disclosure statementThe declare that they have known competing interests or personal relationships appeared influence work reported paper.Authors' contributionsGabriel Cruz: Conceptualisation, Methodology, Collection organisms, Formal analysis, Investigation, Writing original draft; Juliana Moser: review & editing; Saldaña-Serrano: Camila L. V. Bastolla: Analysis biomarkers; Daína Lima: Carlos H. A. M. Gomes: Performed exposure; Castro: methodology; Uclédia dos Santos: Coutinho: Jacó J. Mattos: Maria F. Marques: Funding acquisition, editing, Resources, Supervision.Additional informationFundingThe author(s) there funding associated featured article.
Language: Английский
Citations
4Life cycle exposure to 2-phenylbenzimidazole-5-sulfonic acid disrupts reproductive endocrine system and induces transgenerational adverse effects in zebrafish
Frontiers in Marine Science, Journal Year: 2023, Volume and Issue: 10
Published: Nov. 1, 2023
Global attention has been focused on organic UV filters due to their ubiquity and potential damage aquatic environment, yet the effects of life cycle exposure fish reproduction remain unknown. In present study, influence 2-phenylbenzimidazole-5-sulfonic acid (PBSA) reproductive endocrine system zebrafish was examined, from 6 hours post fertilization (hpf) until 150 days, at levels that near-environmentally relevant (0 20 μg/L). Our results showed PBSA μg/L caused a slight decrease in Gonadosomatic Index (GSI) female F0 generation. Furthermore, this had negatively effect reproduction, accompanied by delayed oocyte maturation, reduced cumulative egg production decreased rate. Additionally, offspring embryos displayed diameter 0.75 hpf, hatching rate 60 increased deformities 72 indicating an adverse transgenerational effect. Moreover, associated with plasma sex hormones 17β-estradiol (E2) 11-ketotestosterone (11-KT), as well altered transcriptional profiles certain genes HPG (hypothalamic–pituitary–gonadal) liver axis. Molecular docking (MD) simulations revealed specific amino residues interact estrogen receptors, confirming its xenoestrogenic properties. Therefore, during can disturb through disruption, thus necessitating strict environmental regulations for disposal protect ecological public health.
Language: Английский
Citations
4UV filters in beach sands from beaches along the Atlantic Ocean coastline in Lagos, Nigeria: Occurrence and risk assessment
Regional Studies in Marine Science, Journal Year: 2024, Volume and Issue: 74, P. 103513 - 103513
Published: April 14, 2024
Language: Английский
Citations
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