6PPD-quinone degradation by unactivated peroxymonosulfate via direct oxidation and enhanced generation of 1O2

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159307 - 159307

Published: Jan. 1, 2025

Language: Английский

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Exposure to 6-PPD Quinone at Environmentally Relevant Concentrations Inhibits Both Lifespan and Healthspan in C. elegans

Environmental Science & Technology, Journal Year: 2023, Volume and Issue: 57(48), P. 19295 - 19303

Published: Nov. 8, 2023

N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6-PPD), one of the most common additives used in rubber, enters environment due to significant emissions tire wear particles. 6-PPD quinone (6-PPDQ) is an important derivative after ozonization. With concentrations ranging from nanograms per liter μg/L, 6-PPDQ has so far been identified a series water samples. Acute lethality coho salmon (LC50 < 1 μg/L) was lower than environmental 6-PPDQ, highlighting exposure risks 6-PPDQ. It becoming increasingly necessary investigate potential toxicity at concentrations. Here, we examined effect on lifespan and healthspan underlying mechanism Caenorhabditis elegans. Exposure (1 10 shortened lifespan. Meanwhile, during aging process, (0.1–10 could decrease both pumping rate locomotion behavior, suggesting healthspan. For molecular mechanism, dysregulation insulin signaling pathway linked In pathway, DAF-2 restricted function DAF-16 activate downstream targets (SOD-3 HSP-6), which turn controlled Additionally, response toxicity, peptides (INS-6, INS-7, DAF-28) corresponding receptor DAF-2. Therefore, environmentally relevant potentially causes damage by activating organisms.

Language: Английский

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Occurrence of p-phenylenediamine antioxidants (PPDs) and PPDs-derived quinones in indoor dust

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 169325 - 169325

Published: Dec. 14, 2023

Language: Английский

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Characterization of N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD)-induced cardiotoxicity in larval zebrafish (Danio rerio)

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 882, P. 163595 - 163595

Published: April 22, 2023

Language: Английский

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Exposure to 6-PPD quinone enhances lipid accumulation through activating metabolic sensors of SBP-1 and MDT-15 in Caenorhabditis elegans

Environmental Pollution, Journal Year: 2023, Volume and Issue: 333, P. 121937 - 121937

Published: June 10, 2023

Language: Английский

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