Dentatacid A: An Unprecedented 2, 3-Seco-arbor-2, 3-dioic Triterpenoid from the Invasive Plant Euphorbia dentata, with Cytotoxicity Effect on Colon Cancer DOI Creative Commons

Chen-Sen Xu,

Yuanling Shao,

Qing Li

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(17), P. 2533 - 2533

Published: Sept. 9, 2024

Euphorbia dentata Michx. is an invasive plant species in China, known for its toxicity and potential to reduce crop yields, posing numerous threats. To gain a deeper understanding of this plant, phytochemical methods were employed isolate 13 terpenoids (1–11, 19, 20) 7 sterols (12–18) from the ethanol extract E. dentata, identifying one new compound 19 compounds. Within spectroscopic such as NMR, HR-ESI-MS, ECD, structures absolute configurations these compounds established. Among them, dentatacid A (11) possesses unprecedented 2, 3-seco-arbor-2, 3-dioic skeleton within biosynthetic pathway proposed. Dentatacid also exhibited excellent anti-proliferative activity against HT-29 (human colorectal adenocarcinoma) cell line, with IC50 value 2.64 ± 0.78 μM, which was further confirmed through network pharmacology molecular docking. This study significantly expands chemical diversity offers insights into resource utilization management perspective natural product discovery.

Language: Английский

Hydrological repair and invasive grass removal restore Rhizophora racemosa mangrove communities in West Africa DOI Creative Commons
Claudia M. Agraz-Hernández,

Ebénézer Houndjinou,

J. E. Reyes Castellanos

et al.

Restoration Ecology, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Mangrove ecosystems face significant threats from climate change and human activities. In West Benin, the invasive grass Paspalum vaginatum disrupts sedimentation hydrology, creating anoxic conditions nutrient imbalances. To address this, we implemented a cost‐effective restoration strategy focused on hydrological repair, engaging local communities to excavate 26 artificial channels clear 19 existing ones, restoring tidal flow 30 ha of degraded mangrove forest. Of 20 were planted with Rhizophora racemosa propagules, while 10 remained unplanted due unsuitable micro‐topographic conditions. This intervention, costing $1394.3 USD per hectare, adjusted sediment levels match natural micro‐topography, enabling recovery suppressing P. . The return Sesuvium portulacastrum stabilized sediments, improved retention, facilitated regeneration. Over 24 months, efforts physicochemical parameters, reduced ammonium acidity, supported planting 250,000 R. propagules at 25 propagules/m 2 across ha. At 785 days post‐planting, survival reached 90%, promoting recolonization by mangroves along channel edges S. in adjacent areas. not reforested exhibited low colonization, reinforcing effectiveness repair. study presents scalable, low‐cost model that integrates repair pioneer species facilitation enhance recovery. While still early recovery, this community‐driven approach establishes strong foundation for long‐term ecological restoration.

Language: Английский

Citations

0

Temporal-spectral-semantic-aware convolutional transformer network for multi-class tidal wetland change detection in Greater Bay Area DOI
Siyu Qian, Zhaohui Xue,

Mingming Jia

et al.

ISPRS Journal of Photogrammetry and Remote Sensing, Journal Year: 2024, Volume and Issue: 216, P. 126 - 141

Published: Aug. 6, 2024

Language: Английский

Citations

3

Dentatacid A: An Unprecedented 2, 3-Seco-arbor-2, 3-dioic Triterpenoid from the Invasive Plant Euphorbia dentata, with Cytotoxicity Effect on Colon Cancer DOI Creative Commons

Chen-Sen Xu,

Yuanling Shao,

Qing Li

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(17), P. 2533 - 2533

Published: Sept. 9, 2024

Euphorbia dentata Michx. is an invasive plant species in China, known for its toxicity and potential to reduce crop yields, posing numerous threats. To gain a deeper understanding of this plant, phytochemical methods were employed isolate 13 terpenoids (1–11, 19, 20) 7 sterols (12–18) from the ethanol extract E. dentata, identifying one new compound 19 compounds. Within spectroscopic such as NMR, HR-ESI-MS, ECD, structures absolute configurations these compounds established. Among them, dentatacid A (11) possesses unprecedented 2, 3-seco-arbor-2, 3-dioic skeleton within biosynthetic pathway proposed. Dentatacid also exhibited excellent anti-proliferative activity against HT-29 (human colorectal adenocarcinoma) cell line, with IC50 value 2.64 ± 0.78 μM, which was further confirmed through network pharmacology molecular docking. This study significantly expands chemical diversity offers insights into resource utilization management perspective natural product discovery.

Language: Английский

Citations

1