The effect of COVID-19 vaccination on symptomatic infection and related symptoms among preterm-born children aged 3–7 years in China DOI Creative Commons
Dan Wang, Jing Ning,

Jingke Cao

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 25, 2024

Vaccination plays a crucial role in preventing and controlling SARS-CoV-2 infections as well their associated adverse outcomes. But there is notable lack of research on the effectiveness COVID-19 vaccination children, particularly those young preterm-born who are more vulnerable to severe outcomes from infection. We aimed determine effect with inactivated vaccines BBIBP-CorV CoronaVac symptomatic infection related symptoms children aged 3-7 years after relaxation prevention control measures December 2022 China. performed retrospective cohort study involving 242 data were collected March 2023. Logistic regression models modified Poisson combined entropy balancing used explore associations against COVID-19, specific symptoms, persistent one month recovery COVID-19. Of recruited 156 (64.5%) vaccinated CoronaVac. After balancing, covariates balanced between unvaccinated groups, standardized mean difference < 0.001. said lowered risk developing (risk ratio [RR] = 0.783; 95% confidence interval [CI]: (0.711, 0.861). Likewise, was decline pneumonia (odds [OR] 0.318; CI 0.110, 0.913), fever (RR 0.710; 0.635, 0.794), high 0.542; 0.297, 0.988), sore throat (OR 0.304; 0.139, 0.664), 0.425; 0.182, 0.993). Immunization provides protection for years.

Language: Английский

A genetically modulated Toll-like receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome DOI Creative Commons
Rehan Khan,

Weizhen Ji,

J Rivera

et al.

The Journal of Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Abstract Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after severe acute respiratory coronavirus 2 (SARS-CoV-2) exposure. To investigate functions, we stimulated ex vivo peripheral blood cells from MIS-C patients with agonists of Toll-like receptors (TLR), key response initiators. We found severely dampened cytokine and elevated gene expression negative regulators TLR signaling. Increased plasma levels zonulin, a gut leakage marker, were also detected. These effects observed fully convalescent months recovery. When investigated the genetic background relation responsiveness, that carrying rare heterozygous variants lysosomal trafficking regulator (LYST) less refractory stimulation exhibited mitochondrial abnormalities altered energy metabolism. Moreover, these LYST variant carriers tended exhibit unfavorable clinical laboratory indicators inflammation, including more profound lymphopenia. The results our observational study have several implications. First, hyporesponsiveness may be associated hyperinflammation excessive or prolonged gut-originated ligands. Second, during protective, since reduced inflammation. Thus, links exist between background, ability establish state, spectrum. Third, possibility exists is one mechanisms driving long disease (COVID), which highlights need monitor long-term consequences MIS-C.

Language: Английский

Citations

1
Life-threatening infections in human newborns: Reconciling age-specific vulnerability and interindividual variability DOI
A. Borghesi

Cellular Immunology, Journal Year: 2024, Volume and Issue: 397-398, P. 104807 - 104807

Published: Jan. 13, 2024

Language: Английский

Citations

4
Restrained memory CD8+T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID DOI Creative Commons
Lucie Rodriguez, Ziyang Tan, Tadepally Lakshmikanth

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 13, 2024

Abstract During the COVID-19 pandemic it was widely described that certain individuals infected by SARS-CoV-2 experience persistent disease signs and symptoms, Long COVID, which in some cases is very severe with life changing consequences. To maximize our chances of identifying underpinnings this illness, we have focused on 121 most from >1000 patients screened specialized clinics Sweden Belgium. We restricted study to subjects objective measures organ damage or dysfunction, >3 months following a verified, but mild-to-moderate infection. By performing systems-level immunological testing comparisons controls fully convalescent similar mild/moderate episode, identify elevated serological responses COVID suggestive chronic antigen stimulation. Persistent viral reservoirs been proposed using multiple orthogonal methods for detection RNA protein plasma subset detectable antigens, minimal overlap across assays, no correlation symptoms immune measurements. Elevated serologic other hand were inversely correlated clonally expanded memory CD8 + T cells, indicating restrained clonal expansion enables persistence, exposure IgG responses, even if antigen-detection blood not universally possible.

Language: Английский

Citations

3
A genetically modulated Toll-like-receptor-tolerant phenotype in peripheral blood cells of children with multisystem inflammatory syndrome DOI Creative Commons
Rehan Khan,

Weizhen Ji,

Jeisac Guzman-Rivera

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 4, 2024

Dysregulated innate immune responses contribute to multisystem inflammatory syndrome in children (MIS-C), characterized by gastrointestinal, mucocutaneous, and/or cardiovascular injury occurring weeks after SARS-CoV-2 exposure. To investigate functions MIS-C, we stimulated

Language: Английский

Citations

2
Post-COVID-19 condition in children: epidemiological evidence stratified by acute disease severity DOI
Coen R. Lap, Caroline L. H. Brackel, Angelique M A M Winkel

et al.

Pediatric Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 27, 2024

Language: Английский

Citations

1
Older Age and Vaccination Protect Against Transaminase Elevation in Pediatric SARS-CoV2 DOI Creative Commons

Antonia Fernandez Ovale,

C. Charles,

Janet E. Rosenbaum

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 1, 2024

Abstract Objectives SARS-CoV2 infection is reported to induce transaminase elevations. There are case reports of severe liver injury in adult patients and some have theorized that acute may be a driver children. While pediatric hepatic has previously been described, clear shifts immunogenic response secondary prior immune exposure vaccination since initial from 2020 warrant further evaluation. We sought identify the impact variant on this phenomenon Methods A retrospective, cross-sectional study seen at two hospital facilities an urban neighborhood New York City between March 2022 was conducted via chart review. Data extracted relating patient’s demographics, clinical presentation, including level care laboratory results comprehensive metabolic panels (CMP). Results 133 cases were identified as having positive CMP obtained same visit. Patients predominantly Black (79.2%) non-Hispanic (87%) with mean age 9.2 years. Risk elevation increased younger higher care. BMI not risk factor noted for elevation. Vaccination decreased degree, incidence, but given low rates unable determine significance protective efficacy. Conclusions Our profound patients, absence correlating our primarily patient population, shift towards non-specific AST windows strong signal vaccine protection. What Known can cause Transaminemia, rare cases, possible fulminant Pediatric infections statistically milder than adult. SARS-Cov2 severity complications like multisystem inflammatory syndrome children declined over time With population immunity elevations increasingly origin substantially decreases Vaccines against degree elevation, likely incidence although needed. Article Summary Cross sectional demonstrates linked age, unvaccinated status,

Language: Английский

Citations

0
Dynamic changes in the circulation of respiratory pathogens in children during and after the containment of the 2019 coronavirus disease pandemic in Kunming, China DOI Creative Commons

Guiqian Zhang,

Kaimei Wang,

Limei Ba

et al.

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

We aimed to determine the changes in frequency of respiratory pathogens and severe acute syndrome coronavirus 2 (SARS-CoV-2) during containment 2019 disease pandemic elucidate epidemiological interference that may have occurred after lifting measures.

Language: Английский

Citations

0
The world’s largest experiment in human immunology DOI
Bali Pulendran

Seminars in Immunology, Journal Year: 2024, Volume and Issue: 73, P. 101888 - 101888

Published: May 1, 2024

Language: Английский

Citations

0
The effect of COVID-19 vaccination on symptomatic infection and related symptoms among preterm-born children aged 3–7 years in China DOI Creative Commons
Dan Wang, Jing Ning,

Jingke Cao

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 25, 2024

Vaccination plays a crucial role in preventing and controlling SARS-CoV-2 infections as well their associated adverse outcomes. But there is notable lack of research on the effectiveness COVID-19 vaccination children, particularly those young preterm-born who are more vulnerable to severe outcomes from infection. We aimed determine effect with inactivated vaccines BBIBP-CorV CoronaVac symptomatic infection related symptoms children aged 3-7 years after relaxation prevention control measures December 2022 China. performed retrospective cohort study involving 242 data were collected March 2023. Logistic regression models modified Poisson combined entropy balancing used explore associations against COVID-19, specific symptoms, persistent one month recovery COVID-19. Of recruited 156 (64.5%) vaccinated CoronaVac. After balancing, covariates balanced between unvaccinated groups, standardized mean difference < 0.001. said lowered risk developing (risk ratio [RR] = 0.783; 95% confidence interval [CI]: (0.711, 0.861). Likewise, was decline pneumonia (odds [OR] 0.318; CI 0.110, 0.913), fever (RR 0.710; 0.635, 0.794), high 0.542; 0.297, 0.988), sore throat (OR 0.304; 0.139, 0.664), 0.425; 0.182, 0.993). Immunization provides protection for years.

Language: Английский

Citations

0