New Perspectives in Innovation Failure Analysis: A taxonomy of general errors and strategic management for reducing risks DOI Creative Commons
Mario Coccia

Technology in Society, Journal Year: 2023, Volume and Issue: 75, P. 102384 - 102384

Published: Oct. 11, 2023

In turbulent environments, one of the fundamental problems is high risk failure in new innovation projects that affects organizational behaviour and performance firms. The study here clarifies theoretical structure project-level proposing a definition three general types determinants: errors planning design, project execution marketization. Innovation when organizations do not achieve main goal because set errors. A case research proposed framework with examples pharmaceutical sector, aerospace aircraft industries, information & communications technologies industries. Results suggest associated difficulty, environmental complexity uncertainty. Different strategies to reduce leading improve technological development are proposed, such as learning processes, adaptation perspective, game theory models, stage-gate method, etc. concept causes can guide R&D managers, designers, analysts, policymakers know determinant how appropriate for competitive advantage markets society.

Language: Английский

Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics DOI Creative Commons

Uttpal Anand,

Abhijit Dey, Arvind K. Singh Chandel

et al.

Genes & Diseases, Journal Year: 2022, Volume and Issue: 10(4), P. 1367 - 1401

Published: March 18, 2022

Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and produce aggressive malignancies that causes millions deaths every year. With the new understanding molecular mechanism(s) disease progression, our knowledge about snowballing, leading to evolution many therapeutic regimes their successive trials. In past few decades, various combinations therapies have been proposed are presently employed in treatment diverse cancers. Targeted drug therapy, immunotherapy, personalized medicines now largely being employed, which were not common a years back. The field cancer discoveries therapeutics evolving fast as type-specific biomarkers progressively identified several types cancers nowadays undergoing systematic therapies, extending patients' disease-free survival thereafter. Although growing evidence shows targeted approach could be future medicine, chemotherapy remains opted option despite its known side effects on patient's physical psychological health. Chemotherapeutic agents/pharmaceuticals served great purpose over decades remained frontline choice for advanced-stage surgery and/or radiation therapy cannot prescribed due specific reasons. present report succinctly reviews existing contemporary advancements assesses status enrolled drugs/pharmaceuticals; it also comprehensively discusses emerging role specific/targeted strategies achieve better clinical success/survival rate patients.

Language: Английский

Citations

755

Factors determining the diffusion of COVID-19 and suggested strategy to prevent future accelerated viral infectivity similar to COVID DOI Open Access
Mario Coccia

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 729, P. 138474 - 138474

Published: April 20, 2020

Language: Английский

Citations

657

Influence of artificial intelligence on technological innovation: Evidence from the panel data of china's manufacturing sectors DOI
Liu Jun,

Huihong Chang,

Jeffrey Yi‐Lin Forrest

et al.

Technological Forecasting and Social Change, Journal Year: 2020, Volume and Issue: 158, P. 120142 - 120142

Published: June 17, 2020

Language: Английский

Citations

393

Real-world data: a brief review of the methods, applications, challenges and opportunities DOI Creative Commons
Fang Liu, Demosthenes B. Panagiotakos

BMC Medical Research Methodology, Journal Year: 2022, Volume and Issue: 22(1)

Published: Nov. 5, 2022

Abstract Background The increased adoption of the internet, social media, wearable devices, e-health services, and other technology-driven services in medicine healthcare has led to rapid generation various types digital data, providing a valuable data source beyond confines traditional clinical trials, epidemiological studies, lab-based experiments. Methods We provide brief overview on type sources real-world common models approaches utilize analyze data. discuss challenges opportunities using for evidence-based decision making This review does not aim be comprehensive or cover all aspects intriguing topic RWD (from both research practical perspectives) but serves as primer provides useful readers who interested this topic. Results Conclusions Real-world hold great potential generating evidence designing conducting confirmatory trials answering questions that may addressed otherwise. voluminosity complexity also call development more appropriate, sophisticated, innovative processing analysis techniques while maintaining scientific rigor findings, attentions ethics harness power

Language: Английский

Citations

235

The relation between length of lockdown, numbers of infected people and deaths of Covid-19, and economic growth of countries: Lessons learned to cope with future pandemics similar to Covid-19 and to constrain the deterioration of economic system DOI Open Access
Mario Coccia

The Science of The Total Environment, Journal Year: 2021, Volume and Issue: 775, P. 145801 - 145801

Published: Feb. 15, 2021

Language: Английский

Citations

221

The impact of first and second wave of the COVID-19 pandemic in society: comparative analysis to support control measures to cope with negative effects of future infectious diseases DOI Open Access
Mario Coccia

Environmental Research, Journal Year: 2021, Volume and Issue: 197, P. 111099 - 111099

Published: April 2, 2021

Language: Английский

Citations

192

Multi-Disease Prediction Based on Deep Learning: A Survey DOI Open Access
Shuxuan Xie, Zengchen Yu,

Zhihan Lv

et al.

Computer Modeling in Engineering & Sciences, Journal Year: 2021, Volume and Issue: 128(2), P. 489 - 522

Published: Jan. 1, 2021

In recent years, the development of artificial intelligence (AI) and gradual beginning AI’s research in medical field have allowed people to see excellent prospects integration AI healthcare. Among them, hot deep learning has shown greater potential applications such as disease prediction drug response prediction. From initial logistic regression model machine model, then today, accuracy been continuously improved, performance all aspects also significantly improved. This article introduces some basic frameworks common diseases, summarizes methods corresponding different diseases. Point out a series problems current prediction, make prospect for future development. It aims clarify effectiveness demonstrates high correlation between The unique feature extraction can still play an important role research.

Language: Английский

Citations

187

High health expenditures and low exposure of population to air pollution as critical factors that can reduce fatality rate in COVID-19 pandemic crisis: a global analysis DOI Open Access
Mario Coccia

Environmental Research, Journal Year: 2021, Volume and Issue: 199, P. 111339 - 111339

Published: May 21, 2021

Language: Английский

Citations

185

Pandemic Prevention: Lessons from COVID-19 DOI Creative Commons
Mario Coccia

Encyclopedia, Journal Year: 2021, Volume and Issue: 1(2), P. 433 - 444

Published: May 31, 2021

Coronavirus disease 2019 (COVID-19) is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which appeared in late 2019, generating a pandemic crisis with high numbers of COVID-19-related infected individuals and deaths manifold countries worldwide. Lessons learned from COVID-19 can be used to prevent threats designing strategies support different policy responses, not limited health system, directed reduce risks emergence viral agents, diffusion infectious diseases negative impact society.

Language: Английский

Citations

181

A theory of the evolution of technology: Technological parasitism and the implications for innovation magement DOI
Mario Coccia, Joshua Watts

Journal of Engineering and Technology Management, Journal Year: 2019, Volume and Issue: 55, P. 101552 - 101552

Published: Dec. 27, 2019

Language: Английский

Citations

159