Environmental science and engineering, Journal Year: 2024, Volume and Issue: unknown, P. 357 - 377
Published: Jan. 1, 2024
Language: Английский
Antioxidants, Journal Year: 2025, Volume and Issue: 14(2), P. 201 - 201
Published: Feb. 10, 2025
Oxidative stress is a common event involved in cancer pathophysiology, frequently accompanied by unique lipid metabolic reprogramming phenomena. caused mainly an imbalance between the production of reactive oxygen species (ROS) and antioxidant system cells. Emerging evidence has reported that oxidative regulates expression activity metabolism-related enzymes, leading to alteration cellular metabolism; this involves significant increase fatty acid synthesis shift way which lipids are taken up utilized. The dysregulation metabolism provides abundant intermediates synthesize biological macromolecules for rapid proliferation cells; moreover, it contributes maintenance intracellular redox homeostasis producing variety reducing agents. Moreover, derivatives metabolites play critical roles signal transduction within cells tumor microenvironment evades immune destruction facilitates invasion metastasis. These findings suggest close relationship during malignant progression cancers. This review focuses on crosstalk reprogramming, in-depth insight into modulation ROS cancers discusses potential strategies targeting therapy.
Language: Английский
Citations
3
The EMBO Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Abstract L-arginine is the most nitrogen-rich amino acid, acting as a key precursor for synthesis of nitrogen-containing metabolites and an essential intermediate in clearance excess nitrogen. Arginine’s side chain possesses guanidino group which has unique biochemical properties, plays primary role nitrogen excretion (urea), cellular signaling (nitric oxide) energy buffering (phosphocreatine). The post-translational modification protein-incorporated arginine by guanidino-group methylation also contributes to epigenetic gene control. Most human cells do not synthesize sufficient meet demand are dependent on exogenous arginine. Thus, dietary important maintaining health, particularly upon physiologic stress. How adapt changes extracellular availability unclear, mostly because nearly all tissue culture media supplemented with supraphysiologic levels Evidence emerging that arginine-deficiency can influence disease progression. Here, we review new insights into importance metabolite, emphasizing central mitochondria synthesis/catabolism recent discovery act molecule regulating expression organelle dynamics.
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143155 - 143155
Published: April 1, 2025
Language: Английский
Citations
0
Biochemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
We have developed a cost-effective strategy for the complete synthesis of azetidinyl coumarin fluorophore derivatives that report changes in physiologic levels glutathione (GSH), which includes more cost- effective probe precursor hydroxyl derivative and its subsequent derivatization to promote subcellular localization. functionalize with cyano side chain similar previous (Jiang X. et al., Nature Communications 2017, 8; 16087) validate 7-azetidinyl conformation as an explanation enhanced GSH-dependent fluorescence. couple different mass dextrans using either no linker or 6C also synthesize morpholino derivative. titrate fluorescence functionalized probes vs [GSH] vitro. load one dextran-conjugated within digestive vacuole (DV) live intraerythrocytic P. falciparum malarial parasites measure cytosolic localization probe. Using significantly improved single-cell photometry (SCP) methods, we show faithfully reports from parasite cytosol, while 70 kDa DV redox homeostasis control chloroquine-sensitive (CQS) artemisinin-sensitive (ARTS) transfectant their genetically matched chloroquine-resistant (CQR)/artemisinin-sensitive (CQR/ARTS) CQR artemisinin-resistant (CQR/ARTR) strains, respectively. quantify rapid these ± drug pulses under live-cell perfusion conditions. The results are important understanding pharmacology antimalarial drugs molecular mechanisms underlying ARTR phenomena.
Language: Английский
Citations
0
Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 258 - 258
Published: Feb. 24, 2025
Oxidative stress, which is characterized by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, has critical roles in the initiation, progression, treatment of gastric cancer. On one hand, excessive ROS accumulation induces oxidative damage cancer cell death. other moderate levels cause genetic mutations dysregulation signaling pathways to promote proliferation, inflammation, angiogenesis, metastasis Notably, emerging evidence revealed that also mediate post-translational modifications (oxPTMs) redox-sensitive proteins, can directly affect protein functions regulate redox cells. Therefore, elucidating regulatory mechanisms stress holds great promise identify novel therapeutic targets or redox-targeting strategies. This review will summarize regulating hallmarks highlight ROS-mediated oxPTMs In addition, we discuss strategies targeting for cancer, with emphasis on use bioactive natural products nanomaterials.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Immunotherapy has fundamentally transformed the clinical treatment landscape for non-small cell lung cancer (NSCLC). While its effectiveness is ultimately limited by patient heterogeneity and immunosuppressive tumor microenvironment. Photodynamic therapy (PDT), as an emerging antitumor immunotherapy, shown unique therapeutic advantages. However, previous studies often overlooked potential toxicity of photosensitizers (PS), making discovery safe effective PS a pressing need. In this study, Aloe Emodin (AE), medicinal plant natural compound, was loaded with copper ions (Cu), self-assembled into nanoparticles (NPs) under modification PEG2k-DSPE-FA. NPs can target, accumulate, reside within sites, responsively releasing AE, thus dual-functioning inducing death via cuproptosis enhancing PDT effects. The LLC tumor-bearing mouse model demonstrated that induce maturation dendritic cells (DCs) in vivo, promote lymphocyte infiltration, transform "cold tumors" "hot significantly enhance efficacy immune checkpoint blockade (ICB). This study provides experimental evidence AE clinically promising agent offers novel perspective synergistic NSCLC.
Language: Английский
Citations
0
Experimental Gerontology, Journal Year: 2024, Volume and Issue: 193, P. 112465 - 112465
Published: May 25, 2024
Overall health relies on features of skeletal muscle that generally decline with age, partly due to mechanisms associated mitochondrial redox imbalance and bioenergetic dysfunction. Previously, aged mice genetically devoid the NAD(P)+ transhydrogenase (NNT, encoded by nicotinamide nucleotide gene), an enzyme involved in NADPH supply, were shown exhibit deficits locomotor behavior. Here, using young, middle-aged, older NNT-deficient (Nnt−/−) age-matched controls (Nnt+/+), we aimed investigate how function motor performance are affected NNT expression aging. Mice subjected wire-hang test assess performance, while bioenergetics was evaluated fiber bundles from soleus, vastus lateralis plantaris muscles. An age-related decrease average score observed middle-aged Nnt−/− compared controls. Although respiratory rates muscles did not significantly differ between genotypes young mice, oxygen consumption soleus mice. Notably, which exhibited highest level, most aging, loss. Additionally, histology fibers revealed increased numbers centralized nuclei indicating abnormal morphology. In summary, our findings suggest deficiency causes impairments dysfunction during aging
Language: Английский
Citations
2
Antioxidants, Journal Year: 2024, Volume and Issue: 13(10), P. 1261 - 1261
Published: Oct. 17, 2024
Coenzyme Q
Language: Английский
Citations
2
Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 423, P. 136869 - 136869
Published: Oct. 30, 2024
Language: Английский
Citations
2
Water Research, Journal Year: 2024, Volume and Issue: 268, P. 122759 - 122759
Published: Nov. 6, 2024
Language: Английский
Citations
2