Gut–X axis

iMeta, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 1, 2025

Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.

Language: Английский

Streamlining Bacterial Gene Regulation via Nucleic Acid Delivery with Gold Nanoclusters

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Abstract Delivery of exogenous nucleic acids (NAs) for gene regulation in bacteria, bypassing the barrier cell wall, is essential advancing fundamental microbiology and genetic engineering, treatment bacterial diseases. However, current methods that rely on electrical or chemical interventions are limited by their complexity, specialized expertise, laboratory‐specific instrumentation. This study explores capability gold nanoclusters (AuNCs) as carriers delivering small‐interfering RNA antisense oligonucleotides into bacteria targeted while shielding them from degradation during transport. By enhancing cytoplasmic membrane permeability, AuNCs enable efficient internalization NAs both Gram‐positive Gram‐negative exerting negligible influence activity. It demonstrated rationally designed can be released within enabling ~70% knockdown mecA Methicillin‐resistant Staphylococcus aureus (MRSA). significantly reduces MRSA's antibiotic resistance enhances oxacillin efficacy. Furthermore, successful silencing ligA Escherichia coli pilQ Pseudomonas aeruginosa highlights broad adaptability approach across diverse species. The AuNCs‐based next‐generation NA delivery system has potential to transform regulation—previously restricted laboratory settings—into a versatile scalable solution real‐world application.

Language: Английский

Toxic effects of emerging pollutants on mucosal organs of teleost fish: A review focusing on mucosal microbiota, physical barrier and immune barrier

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 978, P. 179431 - 179431

Published: April 16, 2025

Language: Английский