Hippocampal area CA2 activity supports social investigation following an acute social stress

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Neuronal activity in the hippocampus is critical for many types of memory acquisition and retrieval influences an animal’s response to stress. Moreover, molecularly distinct principal neurons hippocampal area CA2 are required social recognition aggression mice. To interrogate effects stress on CA2-dependent behaviors, we chemogenetically manipulated neuronal vivo during acute, socially derived stressor tested whether defeat was influenced. One day after acute (aSD), defeated mice spent significantly less time investigating another mouse when compared non-defeated control We found that this avoidant phenotype persisted up one month following a single encounter. When pyramidal neuron inhibited with Gi-DREADD receptors defeat, subject exhibited higher amount avoidance later littermates not expressing DREADDs. inhibition caused reduction submissive defense behaviors aggression. In vitro electrophysiology tracing experiments revealed circuit wherein connect caudal CA1 projection that, turn, project corticolimbic regions including anterior cingulate cortex. Finally, avoidant, significant reductions cFos expression limbic brain areas investigation task 24 h aSD. Taken together, these results indicate support behavioral resilience defensive behavior (vs. fleeing) predictor future Furthermore, preferentially targets population contact cortical where modulated by stressor.

Language: Английский

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Relationships between care burden, resilience, and depressive symptoms among the main family caregivers of stroke patients: A cross-sectional study

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 20, 2022

This study aims to explore the potential mediating role of resilience between care burden and depressive symptoms in family caregivers stroke patients.A cross-sectional was conducted with a convenience sample involving 245 main patients recruited from neurology department Tertiary A hospital China. Mediation analyses were using PROCESS macro (Model 4) for SPSS, applying Bootstrap analysis 5,000 samples 95% confidence interval.The results showed that constant hemiplegia side, Barthel Index, education level, monthly income, time per day, living regression equations, partially mediated correlation mediation effect ratio 26.32%.Resilience plays symptoms.The findings indicated protective alleviating negative influences on symptoms, suggesting resilience-training intervention may be developed mitigate patients.

Language: Английский

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Sleep and Perceived Stress: An Exploratory Mediation Analysis of the Role of Self-Control and Resilience among University Students

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(16), P. 6560 - 6560

Published: Aug. 11, 2023

Background: High levels of stress are frequent in university education, and a lack sleep has been reported to make students more vulnerable stress. The mechanisms through which harms have not sufficiently clarified; therefore, this study aimed explore the mediating role self-control resilience relationship between quality duration perceived Methods: Of 32 first-year college students, 21 (78%) were women, with mean age 18.47 (±0.84). They responded self-administered survey that included questions on stress, resilience, recorded their daily using wristband for six days. Results: Perceived was significantly correlated (r = −0.63), −0.46), −0.35), lower 0.57). Path analysis revealed partially mediated by (R2 0.62; p < 0.01) completely 0.46; 0.01). In both models, had direct effect good-fit index. Conclusion: Being resilient seems play stress; ability can be favored self-control, is directly influenced sleep.

Language: Английский

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A Double Hit of Social and Economic Stress in Mice Precipitates Changes in Decision-Making Strategies

Biological Psychiatry, Journal Year: 2023, Volume and Issue: 96(1), P. 67 - 78

Published: Dec. 21, 2023

Language: Английский

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From childhood experience to stress resilience: mechanisms and interventions

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 58, P. 101405 - 101405

Published: May 21, 2024

Language: Английский

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