Eugenol and lidocaine inhibit voltage-gated Na+ channels from dorsal root ganglion neurons with different mechanisms DOI Creative Commons

Luiz Moreira‐Júnior,

José Henrique Leal‐Cardoso,

Antônio Carlos Cassola

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 26, 2024

Eugenol (EUG) is a bioactive monoterpenoid used as an analgesic, preservative, and flavoring agent. Our new data show EUG voltage-gated Na + channel (VGSC) inhibitor, comparable but not identical to lidocaine (LID). inhibits both total only TTX-R voltage-activated currents (I ) recorded from VGSCs naturally expressed on dorsal root ganglion sensory neurons in rats. Inhibition quick, fully reversible, dose-dependent. biophysical pharmacological analyses showed that LID inhibit with different mechanisms. dose–response relationship characterized by Hill coefficient of 2, while this parameter for the inhibition 1. Furthermore, way LID, modified voltage dependence VGSC activation inactivation processes recovery fast inactivated states entry slow states. In addition, we suggest EUG, interacts pre-open–closed states, according our data.

Language: Английский

CLOVE ESSENTIAL OIL AND EUGENOL: A REVIEW OF THEIR SIGNIFICANCE AND USES DOI

Marina Vinhas Silva,

Alice da Conceição Alves de Lima,

Marina Gomes Silva

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105112 - 105112

Published: Sept. 1, 2024

Language: Английский

Citations

15
Cisplatin-eugenol Pt(IV) prodrugs target colon cancer stem cells: A novel strategy for enhanced anticancer efficacy DOI Open Access
Vojtěch Novohradský, Tomer Babu, Hana Kostrhunová

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117854 - 117854

Published: Jan. 18, 2025

Language: Английский

Citations

1
Unravelling the correlations between predominant microbiota with physicochemical properties and volatile compounds in sauce-braised duck wings during cold storage DOI Creative Commons
Mingming Hu, Chuanqi Zhang,

S. T. Wu

et al.

LWT, Journal Year: 2025, Volume and Issue: unknown, P. 117569 - 117569

Published: Feb. 1, 2025

Language: Английский

Citations

0
Exploring the Food Safety and Preservation Landscape of Myristica fragrans (L.) against Foodborne Pathogen: A Review of Current Knowledge DOI Creative Commons

Zaryab Shafi,

Vinay Kumar Pandey, Umme Habiba

et al.

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101639 - 101639

Published: Jan. 1, 2025

Language: Английский

Citations

0
Microwave-assisted Click Synthesis, Characterisation, and In silico Studies of novel 2H-chromene-1,2,3-triazolyl glycoconjugates as Potent Anticancer and Antibacterial agents DOI
Bhabani Shankar Panda, Mohammed Ansar Ahemad,

Suhasini Mohapatra

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1318, P. 139323 - 139323

Published: July 17, 2024

Language: Английский

Citations

3
In Vitro Antiviral Activity of Eugenol on Singapore Grouper Iridovirus DOI

Yewen Wang,

Yunxiang Jiang,

Jiatao Chen

et al.

Fish & Shellfish Immunology, Journal Year: 2024, Volume and Issue: 151, P. 109748 - 109748

Published: July 2, 2024

Language: Английский

Citations

2
Eugenol-Loaded Lipid Nanoparticles-Derived Hydrogels Ameliorate Psoriasis-like Skin Lesions by Lowering Oxidative Stress and Modulating Inflammation DOI
Roshan Keshari,

Abhay Tharmatt,

Mamatha M. Pillai

et al.

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(11), P. 3592 - 3606

Published: Oct. 22, 2024

Psoriasis is a chronic T-cell-mediated autoimmune skin disorder characterized by excessive epidermal thickening, overproliferation of keratinocyte, disruption cell differentiation, and increased blood vessel growth in the dermal layer. Despite common use corticosteroids psoriasis treatment, their limited efficacy numerous side effects pose significant challenges. This research introduces promising alternative approach encapsulating eugenol (EU) soya phosphatidylcholine (SPC) nanoparticles (EUNPs) which showed spherical shape with hydrodynamic size approximately 200 nm, polydispersity index 0.23, encapsulation efficiency 85% having good colloidal stability indicated ζ-potential -27 mV. Later on, these EUNPs were formulated into topical hydrogel system using Carbopol 974P (EUNPGel), exhibited superior drug loading, enhanced release kinetics for 48 h, long-term stability, ability to scavenge reactive oxygen species (ROS). Furthermore, inhibited keratinocyte proliferation, induced apoptosis, augmented uptake IL-6-mediated inflammation human cells. Application EUNPs-loaded gels (EUNPGel) imiquimod-induced psoriatic lesions demonstrated effective penetration, suppressed hyperplasia restored growth. led remarkable reduction Area Severity Index (PASI) score from 3.75 0.5 within 5 days. novel enhances ROS scavenging capacity, improves cellular uptake, facilitates penetration retention, reduces activity hyperactive immune cells, suggests potential applications treating other immune-related disorders such as acne atopic dermatitis.

Language: Английский

Citations

2
Eugenol and lidocaine inhibit voltage-gated Na+ channels from dorsal root ganglion neurons with different mechanisms DOI Creative Commons

Luiz Moreira‐Júnior,

José Henrique Leal‐Cardoso,

Antônio Carlos Cassola

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 26, 2024

Eugenol (EUG) is a bioactive monoterpenoid used as an analgesic, preservative, and flavoring agent. Our new data show EUG voltage-gated Na + channel (VGSC) inhibitor, comparable but not identical to lidocaine (LID). inhibits both total only TTX-R voltage-activated currents (I ) recorded from VGSCs naturally expressed on dorsal root ganglion sensory neurons in rats. Inhibition quick, fully reversible, dose-dependent. biophysical pharmacological analyses showed that LID inhibit with different mechanisms. dose–response relationship characterized by Hill coefficient of 2, while this parameter for the inhibition 1. Furthermore, way LID, modified voltage dependence VGSC activation inactivation processes recovery fast inactivated states entry slow states. In addition, we suggest EUG, interacts pre-open–closed states, according our data.

Language: Английский

Citations

0