Micromachines,
Journal Year:
2024,
Volume and Issue:
15(4), P. 466 - 466
Published: March 29, 2024
Acoutofluidics
is
an
increasingly
developing
and
maturing
technical
discipline.
With
the
advantages
of
being
label-free,
non-contact,
bio-friendly,
high-resolution,
remote-controllable,
it
very
suitable
for
operation
living
cells.
After
decades
fundamental
laboratory
research,
its
principles
have
become
clear,
manufacturing
technology
has
gradually
popularized.
Presently,
various
imaginative
applications
continue
to
emerge
are
constantly
improved.
Here,
we
introduce
development
acoustofluidic
actuation
from
perspective
related
manipulation
on
Among
them,
focus
main
directions
such
as
sorting,
tissue
engineering,
microscopy,
biophysical
therapy.
This
review
aims
provide
a
concise
summary
current
state
research
bridge
past
developments
with
future
directions,
offering
researchers
comprehensive
overview
sparking
innovation
in
field.
Ultrasonics Sonochemistry,
Journal Year:
2024,
Volume and Issue:
107, P. 106938 - 106938
Published: May 31, 2024
We
investigate
the
effect
of
ultrasound
on
evaporation
and
crystallization
sessile
NaCl
solution
droplets
which
were
positioned
in
traveling
or
standing
wave
field.
The
experimental
results
indicated
that
field
can
significantly
accelerate
rate
refine
crystal
grains.
By
adjusting
distance
between
emitter,
it
is
found
that,
field,
droplet
time
for
appearance
grains
exhibited
a
fluctuating
increase
as
droplet-emitter
increased.
While
ultrasound,
increases
with
increasing
distance.
Overall,
has
stronger
grain
refinement
than
attributed
to
decrease
critical
nucleation
radius
caused
by
energy
accelerated
rate.
In
addition,
breakage
ultrasonic
cavitation
would
also
lead
refinement.
Ultrasonics Sonochemistry,
Journal Year:
2023,
Volume and Issue:
99, P. 106575 - 106575
Published: Sept. 4, 2023
Ultrasonic
surface
acoustic
wave
(SAW)-induced
streaming
flow
(ASF)
has
been
utilized
for
microfluidic
control,
patterning,
and
mixing.
Most
previous
research
employed
cross-type
SAW
acousto-microfluidic
mixers,
in
which
the
SAWs
propagated
perpendicular
to
direction.
In
this
configuration,
mixing
was
induced
predominantly
by
horizontal
component
of
force,
usually
much
smaller
than
vertical
component,
leading
energy
inefficiency
limited
controllability.
Here,
we
propose
a
vertical-type
ultrasonic
mixer
achieve
rapid
with
improved
efficiency
We
conducted
in-depth
numerical
experimental
investigations
SAW-induced
ASF
elucidate
acousto-hydrodynamic
phenomenon
under
varying
conditions
total
rate,
amplitude,
fluid
viscosity
conditions.
computational
dynamics
simulations
visualization
micro-prism-embedded
microchannels
ASF.
found
that
vortices
served
as
hydrodynamic
barrier
co-flow
streams
controlled
proposed
device.
For
proof-of-concept
application,
performed
chemical
additive-free
red
blood
cell
lysis
achieved
high
based
on
physical
interactions
suspended
cells
vortical
flows.
believe
SAW-based
can
be
broadly
various
applications
require
rapid,
Small Science,
Journal Year:
2024,
Volume and Issue:
4(4)
Published: Feb. 2, 2024
From
deciphering
infection
and
disease
mechanisms
to
identifying
novel
biomarkers
personalizing
treatments,
the
characteristics
of
individual
cells
can
provide
significant
insights
into
a
variety
biological
processes
facilitate
decision‐making
in
biomedical
environments.
Conventional
single‐cell
analysis
methods
are
limited
terms
cost,
contamination
risks,
sample
volumes,
times,
throughput,
sensitivity,
selectivity.
Although
microfluidic
approaches
have
been
suggested
as
low‐cost,
information‐rich,
high‐throughput
alternative
conventional
isolation
methods,
limitations
such
necessary
off‐chip
pre‐
post‐processing
well
systems
designed
for
workflows
restricted
their
applications.
In
this
review,
comprehensive
overview
recent
advances
integrated
microfluidics
on‐chip
three
prominent
application
domains
provided:
investigation
somatic
(particularly
cancer
immune
cells),
stem
cells,
microorganisms.
Also,
use
cell
separation
(e.g.,
dielectrophoresis)
unconventional
or
ways,
which
advance
integration
multiple
systems,
is
discussed.
Finally,
critical
discussion
related
current
how
they
could
be
overcome
provided.
Lab on a Chip,
Journal Year:
2024,
Volume and Issue:
24(10), P. 2802 - 2810
Published: Jan. 1, 2024
An
acoustofluidic
platform
for
controllable
size
liposome
synthesis
using
microfluidic
confined
acoustic
streaming
vortex.
It
combines
the
features
of
both
hydrodynamic
flow
focusing
and
rapid
micro-mixing.
Lab on a Chip,
Journal Year:
2023,
Volume and Issue:
23(19), P. 4343 - 4351
Published: Jan. 1, 2023
Trace
biological
sample
detection
is
critical
for
the
analysis
of
pathologies
in
biomedicine.
Integration
microfluidic
manipulation
techniques
typically
strengthens
biosensing
performance.
For
instance,
using
isothermal
amplification
reactions
to
sense
trace
miRNA
peripheral
circulation
lacks
a
sufficiently
complex
pretreatment
process
that
limits
sensitivity
on-chip
detection.
Herein
we
propose
an
orthogonal
tunable
acoustic
tweezer
(OTAT)
simultaneously
actuate
transportation
and
centrifugation
μ-droplets
on
single
device.
The
OTAT
enables
diversified
modes
droplet
such
as
unidirectional
transport,
multi-direction
round-trip
tilt
angle
movement,
multi-droplet
fusion,
continuous
dynamic
droplets
simultaneously.
multiplicity
modalities
focusing
loaded
analyte
at
center
or
constant
rotation
about
axis
droplet.
We
herein
demonstrate
OTAT's
ability
transportation,
centrifugation-based
two
with
biomarkers
multiple
mixtures,
well
facilitating
increase
fluorescence
by
order
magnitude
compared
traditional
tube
reaction
methods.
results
OTAT-based
acoustofluidic
platform's
combine
wide
range
mechanisms
provide
higher
accuracy
one-stop
point-of-care
disease
diagnosis.
Engineering,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Ultrasound-enabled
nanomedicine
leverages
ultrasound
to
amplify
the
capabilities
of
engineered
nanosystems,
paving
way
for
innovative
diagnostic
and
therapeutic
breakthroughs
in
conventional
nanomedicine.
As
a
burgeoning
discipline,
past
overviews
have
sometimes
offered
fragmented
perspective,
lacking
comprehensive
view.
This
review
presents
systematic
exploration
latest
advancements
ultrasound-enabled
nanomedicine,
with
particular
emphasis
on
oncology.
Covered
topics
include
molecular
imaging
tumors,
separation
tumor
markers,
penetration
through
physiological
barriers,
perforation
cell
membranes,
targeted
drug
release
activation
strategies,
an
array
sonotherapies
oncological
treatments.
We
delve
into
research
framework
each
topic,
foundational
design
their
associated
mechanisms.
Moreover,
we
highlight
recent
pivotal
aimed
at
deepening
reader's
understanding
this
intricate
domain.
underscores
integration
theories
within
aspiring
ignite
advanced
theoretical
insights
introduce
paradigms.
In
conclusion,
outline
current
challenges
prospective
directions.
An
enhanced
focus
these
areas
will
expedite
advancement
