Molecules,
Journal Year:
2024,
Volume and Issue:
29(13), P. 3205 - 3205
Published: July 5, 2024
This
review
is
dedicated
to
sustainable
practices
in
liquid
chromatography.
HPLC
and
UHPLC
methods
contribute
significantly
routine
analytical
techniques.
Therefore,
the
transfer
of
classical
chromatographic
into
ones
utmost
importance
moving
toward
development
goals.
Among
other
principles
render
a
method
green,
substitution
organic
solvent
component
mobile
phase
with
greener
one
received
great
attention.
concentrates
on
choosing
best
alternative
green
replace
for
easy,
rapid
more
normal
or
reversed-phase
The
main
focus
this
will
be
describing
non-green
white
an
effort
elevate
sustainability
chemistry.
greenness
properties
ranking,
addition
suitability
seventeen
solvents
chromatography,
are
mentioned
have
clear
insight
issue
rapidly
appropriate
one.
A
simple
guide
proposed
making
sustainable.
Green Analytical Chemistry,
Journal Year:
2023,
Volume and Issue:
8, P. 100088 - 100088
Published: Dec. 4, 2023
This
study
evaluates
three
spectrophotometric
techniques
for
quantifying
a
binary
combination
of
raloxifene
and
aspirin
in
terms
whiteness
greenness.
Application
green
white
analytical
chemistry
has
gained
widespread
acceptance
the
community.
The
greenness
assessment
were
evaluated
using
approaches:
Complex
procedure
index,
Analytical
GREEnness
calculator
Red
Green
Blue
additive
model.
technique
(I)
uses
simultaneous
equation
methodology
at
285
nm
222
nm,
respectively.
Method
(II)
includes
area
under
curve
operating
(280-290)
(217-227)
aspirin,
(III)
operates
first
derivative
method
269
216
nm.
linearity
range
was
2-14
µg/ml
methods.
P-
Values
found
satisfactory
95%
level
confidence.
These
intended
mixture
analysis
investigational
formulations
with
high
recoveries.
developed
methods
validated
according
to
ICH
guidelines.
have
been
utilized
routine
simultaneously
determine
without
pre-extraction.
BMC Chemistry,
Journal Year:
2025,
Volume and Issue:
19(1)
Published: Feb. 17, 2025
The
developed
method
for
simultaneous
detection
of
levodopa
and
carbidopa
was
able
to
separate
the
peaks
drug
sodium
bisulfite
in
in-vitro
release
samples
stability
samples.
Levodopa
(LD),
a
pro-drug
dopamine,
is
used
as
gold
standard
treatment
Parkinson's
disease.
It
usually
prescribed
with
(CD)
prevent
conversion
dopamine
peripherally,
thus
reducing
undesirable
side
effects.
Both
drugs
are
unstable
at
pH
7.4
beyond
24
h
due
their
oxidation,
therefore
0.2%
added
formulation
an
antioxidant.
separation
performed
by
gradient
elution
using
Luna-C18
column
(250
×
4.6
mm,
5
µm)
flow
rate
1
ml/min.
mobile
phase
composed
A
30
mM
potassium
phosphate
acetonitrile
(95:5,
v/v)
35
tetrabutylammonium
hydrogen
sulphate
B
containing
(50:50
v/v).
Drug
were
detected
280
nm
retention
times
3.05
±
0.001
min
LD
3.64
CD.
validation
according
US
FDA
guidelines
results
found
be
within
acceptable
limits.
linear
from
10-100
µg/ml
(r2
=
0.999)
CD,
respectively.
applied
studying
in-situ
gel.
environmental
impact
evaluated
various
greenness
assessment
tools.
